Autoantibodies neutralizing type I IFNs underlie severe tick-borne encephalitis in ∼10% of patients
Adrian Gervais,
Astrid Marchal,
Andrea Fortova
et al.
Abstract:Tick-borne encephalitis (TBE) virus (TBEV) is transmitted to humans via tick bites. Infection is benign in >90% of the cases but can cause mild (<5%), moderate (<4%), or severe (<1%) encephalitis. We show here that ∼10% of patients hospitalized for severe TBE in cohorts from Austria, Czech Republic, and France carry auto-Abs neutralizing IFN-α2, -β, and/or -ω at the onset of disease, contrasting with only ∼1% of patients with moderate and mild TBE. These auto-Abs were found in two o… Show more
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