Autoantibodies in the Pathogenesis, Diagnosis, and Prognosis of Juvenile Idiopathic Arthritis

Mahmud, Shawn A.; Binstadt, Bryce A.

doi:10.3389/fimmu.2018.03168

Cited by 70 publications

(80 citation statements)

References 125 publications

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“…Perturbations in the intestinal microbiome in rodent and human SpA could be because of imbalances in type 1 and type 17 cytokine production 169,170 . A recent study in HLA-B*27 transgenic rats emphasizes the relationship between the host genetic background and associated changes in multiple microbes in establishing an inflammatory environment that promotes arthritis 171 173 , and the absence of RF and ACPA autoantibodies (as well as the absence of anti-nuclear antibodies in most patients) 174 . However, some evidence supports a contribution from CD4 + T cells to established sJIA [175][176][177][178] , and a subset of patients with sJIA develop chronic erosive arthritis without continued systemic features 179 .…”

Section: [H1] Mechanisms Of Hla Disease Associationsmentioning

confidence: 99%

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications

2019

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Our understanding of the mechanisms underlying HLA associations with inflammatory arthritis continues to evolve. Disease associations have been refined, and interactions of HLA genotype with other genes and environmental risk factors in determining disease risk have been identified. This Review provides basic information on the genetics and molecular function of HLA molecules, as well as general features of HLA associations with disease. We summarise evidence for various peptidedependent and peptide-independent mechanisms by which HLA alleles might contribute to the pathogenesis of three types of inflammatory arthritis: rheumatoid arthritis, spondyloarthritis and systemic juvenile idiopathic arthritis. Also discussed are HLA allelic associations that shed light on the genetic heterogeneity of inflammatory arthritides and on the relationships between adult and pediatric forms of arthritis. Clinical implications range from improved diagnosis and outcome prediction to the possibility of using HLA associations in developing personalized strategies for the treatment and prevention of these diseases. [ED: Some general editorial comments are replied to in the marginal comments. For replies to reviewers, please see the accompanying file.]

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Section: [H1] Mechanisms Of Hla Disease Associationsmentioning

confidence: 99%

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications

2019

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“…The possibility that ICI‐IA may encompass distinct subgroups of inflammatory arthropathies is reminiscent of JIA. There are currently seven subgroups of JIA that have been defined, distinguished by clinical course and serological features (reviewed in Mahmud and Binstadt). Like patients with ICI‐IA, the RF‐positive subgroup of JIA that is similar to adult RA comprises only a small fraction of the total JIA population, less than 5%, and many of the RF‐positive pediatric patients also have ACPAs .…”

Section: Serologymentioning

confidence: 99%

Immune checkpoint inhibitor–induced inflammatory arthritis as a model of autoimmune arthritis

Cappelli¹,

Thomas²,

Bingham³

et al. 2020

Immunological Reviews

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The development of inflammatory arthritis in patients receiving immune checkpoint inhibitor therapy is increasingly recognized due to the growing use of these drugs for the treatment of cancer. This represents an important opportunity not only to define the mechanisms responsible for the development of this immune‐related adverse event and to ultimately predict or prevent its development, but also to provide a unique window into early events in the development of inflammatory arthritis. Knowledge gained through the study of this patient population, for which the inciting event is known, could shed light into the pathogenesis of autoimmune arthritis. This review will highlight the clinical and immunologic features of these entities to define common elements for future study.

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“…Juvenile idiopathic arthritis (JIA) is a heterogeneous group of diseases which encompasses all forms of arthritis of unknown aetiology lasting for at least 6 weeks and with onset before the age of 16 [1,2]. Due to lacking pathognomonic features, the diagnosis of JIA is made by exclusion of all possible causes of chronic arthritis in childhood [3,4]. The International League of Associations for Rheumatology (ILAR) has de ned seven subtypes of JIA [2].…”

Section: Introductionmentioning

confidence: 99%

“…While there are shared genetic and immunologic features between JIA and rheumatoid arthritis (RA) in adults, only a small subset of JIA patients with polyarticular disease and a positive rheumatoid factor (RF) clinically resembles adult RA patients [5]. Advances in our understanding of the JIA pathogenesis over the last two decades have revolutionized therapy, reduced morbidity, and improved quality of life for those affected [3,4]. Various autoantibodies have been associated with JIA, including anti-nuclear antibodies (ANA), RF, anti-citrullinated protein autoantibodies (ACPA), and others.…”

Section: Introductionmentioning

confidence: 99%

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Concentration of survivin in children with oligo- and poly-articular juvenile idiopathic arthritis (jia): diagnostic and prognostic value – single center study.

Lipińska

Kaszkowiak

Małachowska

et al. 2020

Preprint

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BACKGROUND: The goal of the study was to assess the diagnostic and prognostic value of survivin in Juvenile Idiopathic Arthritis (JIA).METHODS: Seventy children with JIA – 59 newly diagnosed and 11 biologically treated (46 girls and 17 boys) aged 1.5-18 years and 29 healthy children as a control group, appropriately matched in terms of sex and age, were included into the study. The disease activity was established on the basis of JADAS-27 criteria. Concentration of survivin was assessed by an ELISA test in serum and also 18 matched synovial fluid samples collected from patients with JIA.RESULTS: Children with JIA were divided according to the subtype of the JIA. In 65.7% of patients oligoarthritis was diagnosed. The largest group comprised children of low disease activity (62.9%) according to JADAS-27. The serum concentration of survivin was significantly higher in children with JIA compared to the controls (p<0.001). Concentration of survivin was higher among patients positive for anti-cyclic citrullinated peptide autoantibodies (ACPA) (p=0.001). In all synovial fluid samples the concentration of survivin was higher than in matched serum (p=0.003). Serum survivin concentration was not significantly associated with radiological damage status or active synovitis assessed by joint ultrasonography. Survivin level was not significantly associated with disease duration time or treatment with TNF-α inhibitors in DMARD’s non-responders. CONCLUSIONS: Survivin could be an independent biomarker helpful in the diagnosis of JIA. Survivin measurement should be considered as an aiding tool identifying DMARD’s non-responders.

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Autoantibodies in the Pathogenesis, Diagnosis, and Prognosis of Juvenile Idiopathic Arthritis

Cited by 70 publications

References 125 publications

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications

Immune checkpoint inhibitor–induced inflammatory arthritis as a model of autoimmune arthritis

Concentration of survivin in children with oligo- and poly-articular juvenile idiopathic arthritis (jia): diagnostic and prognostic value – single center study.

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