Autoantibodies in psoriatic arthritis: are they of pathogenic relevance?

Zhu, Jing; Shi, Xiao; Chu, Cong Qiu

doi:10.1097/cm9.0000000000001228

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…[31] The mechanism of Dkk-1 in bone destruction seems to be regulated by cytokines in the local inflammatory microenvironments of joints, such as TNF-a, interleukin (IL)-6, IL-8, IL-17, and matrix metalloproteinases. [22,25,32,33] The cytokines interacted within a complicated regulatory network in inflammatory arthritis, modulating the interactions among immune cells, fibroblast-like synoviocytes, and osteoblasts. Bone erosion and bone formation are successive processes in PsA, indicating that elevation of serum Dkk-1 is a predictive indicator for bone erosion.…”

Section: Discussionmentioning

confidence: 99%

“…Dkk-1 has also been observed to be associated with spondyloarthritis and even with erosive arthritis in patients with systemic lupus erythematosus [31] . The mechanism of Dkk-1 in bone destruction seems to be regulated by cytokines in the local inflammatory microenvironments of joints, such as TNF-α, interleukin (IL)-6, IL-8, IL-17, and matrix metalloproteinases [22,25,32,33] . The cytokines interacted within a complicated regulatory network in inflammatory arthritis, modulating the interactions among immune cells, fibroblast-like synoviocytes, and osteoblasts.…”

Section: Discussionmentioning

confidence: 99%

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Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis

Chung

Sun

et al. 2021

Chinese Medical Journal

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Background: Psoriatic arthritis (PsA) is an inflammatory arthropathy characterized by psoriasis and bone erosion on radiology. Dickkopf-1 (Dkk-1) is considered to be the main inhibitor of the Wnt signaling pathway and results in reduced osteoblast proliferation. The aim of this study was to investigate the serum level of Dkk-1 and its association with bone erosion in PsA patients. Methods: Serum Dkk-1 levels were measured by enzyme-linked immunosorbent assay (ELISA) in 69 patients with PsA and 60 controls, including 39 rheumatoid arthritis (RA) patients, and 21 healthy controls (HCs). Rheumatoid factor and anti-cyclic citrullinated peptide levels were also determined by ELISA. The association of Dkk-1 level with clinical and laboratory features of PsA was analyzed. Logistic regression analysis was used to analyze the risk factors for bone erosion in PsA. Results: Dkk-1 was elevated in 68.1% (47/69) of the patients with PsA, 46.2% (18/39) of RA patients, and 9.5% (2/21) of HCs. Serum Dkk-1 concentration was significantly higher in PsA patients compared with that in HCs. The level of serum Dkk-1 was correlated with a swollen joint count, and levels of complement components 3 and 4. Elevated Dkk-1 level (odds ratio = 4.440, 95% confidence interval: 1.246–15.817, P = 0.021) was identified as the risk factor for bone erosion in PsA. Conclusions: The serum level of Dkk-1 is abnormally elevated in PsA patients. The elevation of Dkk-1 might be involved in the mechanism of bone erosion in patients with PsA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis

Chung

Sun

et al. 2021

Chinese Medical Journal

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“…Consistent with an autoimmune inflammation in PsA is the recently reported clonal expansion of CD8 + T cells in the synovial fluid of PsA 11. Further, diverse autoantibodies have been reported in PsA, although their pathogenicity has not been established 12 13. In addition to HLA, non-HLA innate immunity genes have been associated with psoriasis and PsA, suggesting the pathogenic relevance of innate immune dysfunction 1.…”

Section: Introductionmentioning

confidence: 75%

Identification of variants in genes associated with autoinflammatory disorders in a cohort of patients with psoriatic arthritis

et al. 2022

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ObjectivesBesides adaptive immunity genes, genetic risk factors for psoriatic arthritis (PsA) include innate immunity loci, which suggests an autoinflammatory disease mechanism, at least in a subset of patients. Here, we aimed at investigating the autoinflammatory genetic background of PsA.MethodsA total of 120 patients with PsA visiting the outpatient clinics of the Hannover University hospital underwent targeted next-generation sequencing, searching for variations in genes linked with inborn errors of immunity classified as autoinflammatory disorders (AIDs). Deleteriousness of rare variants was evaluated through in silico analysis.ResultsWe found 45 rare predicted deleterious variants in 37 out of 120 (30.8%) patients with PsA. Relatively common were variants in AP1S3, PLCG2, NOD2 and NLRP12. All 45 variants were monoallelic and 25 of them, identified in 20 out of 120 (16.7%) patients, were localised in genes associated with autosomal dominant (AD) disorders. Detection of those variants is associated with pustular psoriasis or a coexisting inflammatory bowel disease (IBD).ConclusionsApproximately 30% of patients with PsA harboured at least one variant in a gene associated with an AID, suggesting an autoinflammatory disease mechanism. Detection of variants in genes linked to AD-AIDs may explain extra-articular manifestations of PsA, such as pustular psoriasis and IBD.

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Cardiovascular Risk and Systemic Inflammation in Rheumatoid Arthritis: Comparative Insights with Psoriatic Arthritis

Kęska,

Suchy

2024

Arch Pharm Pract

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Autoantibodies in psoriatic arthritis: are they of pathogenic relevance?

Cited by 3 publications

References 27 publications

Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis

Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis

Identification of variants in genes associated with autoinflammatory disorders in a cohort of patients with psoriatic arthritis

Cardiovascular Risk and Systemic Inflammation in Rheumatoid Arthritis: Comparative Insights with Psoriatic Arthritis

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