Autoantibodies in hepatitis delta

Philipp, Thomas; Obermayer-Straub, Petra; Manns, MP

doi:10.1016/0753-3322(96)82663-1

Cited by 6 publications

(6 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multiple studies have shown the capacity of HDV antigens to stimulate expression of or directly interact with multiple interferon-stimulated genes and genes associated with pSS pathogenesis, including SSB/La protein [38–41]. Prior studies have associated HDV infections with the development of autoantibodies, including ANA, liver-kidney microsomal antibodies (LKM), and smooth muscle antibodies (SMA), among others [42–44]. Our data, in connection with prior reports of HDV-mediated autoantibody development, further support the potential of HDV to trigger development of pSS-associated autoimmunity.…”

Section: Discussionsupporting

confidence: 84%

Hepatitis Delta Virus Detected in Salivary Glands of Sjögren’s Syndrome Patients and Recapitulates a Sjögren’s Syndrome-Like Phenotype in Vivo

Weller

Gardener

Bogus

et al. 2016

PAI

View full text Add to dashboard Cite

Background Low-level, chronic viral infections have been suspect in the development of select autoimmune diseases, including primary Sjögren’s syndrome (pSS). Multiple studies have shown stimulation of antiviral response pathways in pSS tissues suggestive of a viral infection. Yet, with this data in hand, a causal link between a viral infection and development of pSS had not been identified. Therefore, a study was designed to further define the viral landscape within pSS-affected salivary gland tissue to identify potential viral-mediated triggers in the pathogenesis of this autoimmune disease. Methods A viral microarray was utilized to measure viral transcripts present in salivary gland tissue from patients diagnosed with pSS compared to healthy controls. Murine models of salivary gland localized HDV antigen expression were developed to evaluate the capacity of a chronic HDV signature to trigger the development of a pSS-like phenotype. Results Through this analysis, two distinct viral profiles were identified, including the increased presence of hepatitis delta virus (HDV) in 50% of pSS patients evaluated. Presence of HDV antigen and sequence were confirmed in minor salivary gland tissue. Patients with elevated HDV levels in salivary gland tissue were negative for detectible hepatitis B virus (HBV) surface antigen and antibodies to HBV or HDV. Expression of HDV antigens in vivo resulted in reduced stimulated saliva flow, increase in focal lymphocytic infiltrates, and development of autoantibodies. Conclusion Identification of HDV in pSS patients and induction of a complete pSS-like phenotype in vivo provides further support of a viral-mediated etiopathology in the development of pSS.

show abstract

Section: Discussionsupporting

confidence: 84%

Hepatitis Delta Virus Detected in Salivary Glands of Sjögren’s Syndrome Patients and Recapitulates a Sjögren’s Syndrome-Like Phenotype in Vivo

Weller

Gardener

Bogus

et al. 2016

PAI

View full text Add to dashboard Cite

show abstract

“…These antibodies are found in 13% of patients with chronic hepatitis D, 8% of patients with type 2 autoimmune hepatitis, and rare patients with chronic hepatitis C [162][163][164][165]. They are directed against the UGT1 enzymes [166,167], and they are distinguished from the anti-LKM1 occasionally recognized in chronic hepatitis C by their substrate specificity [168].…”

Section: Prognostic Attributesmentioning

confidence: 99%

Autoantibodies as Prognostic Markers in Autoimmune Liver Disease

Czaja

2010

Dig Dis Sci

View full text Add to dashboard Cite

Certain autoantibodies in autoimmune liver disease have prognostic implications that are under-utilized and under-developed. The goals of this review are to indicate progress in characterizing the autoantibodies with prognostic connotations and to indicate the feasibility and importance of discovering other markers. Prime source and review articles in English were selected by a Medline search through 2010. Antibodies to soluble liver antigen, actin, liver cytosol type 1, asialoglycoprotein receptor, chromatin, cyclic citrullinated peptide, and uridine glucuronosyltransferases have been associated with the occurrence, severity, and progression of autoimmune hepatitis, and antibodies to Sp100, gp210, and centromere have had similar implications in primary biliary cirrhosis. Antibodies to soluble liver antigen have shown the most promise in autoimmune hepatitis as they have been associated with severe histological changes, long durations of treatment, relapse after drug withdrawal, and high frequency of liver failure. Antibodies to the nuclear rim pore protein, gp210, have shown the most promise in primary biliary cirrhosis as they have been associated with severe interface hepatitis, lobular inflammation, and progression to liver failure. The major limitations of the autoantibodies have been their lack of standardized assays, low negative predictabilities, and fluctuating levels. Performance parameters will improve as critical pathogenic pathways, comprehensive testing batteries, and standardized assays through international exchange workshops are developed. Progress has been made in identifying the serological markers of prognosis in autoimmune liver disease, and they promise to reflect critical disease mechanisms and enhance patient management.

show abstract

“…They play an important role in maintaining nuclear envelope integrity and organizing high order nuclear structures during mitosis in higher eukaryotes. That lamin C can function as a nuclear autoantigen has been described before, especially in acute hepatitis [16,17]. In contrast, according to our knowledge, autoantibodies to cytokeratin 15 and mitochondrial cytochrome oxidase II have not been described before.…”

Section: Discussionmentioning

confidence: 72%

Analysis of the B cell repertoire against autoantigens in patients with giant cell arteritis and polymyalgia rheumatica

Schmits

Kubuschok

Schuster

et al. 2002

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SUMMARY The analysis of the antibody repertoire of patients with giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) might identify target antigens of the autoimmune response with potential relevance to our understanding of the pathogenesis of the disease and to the development of serodiagnostic tests. To detect such antigens, we screened a cDNA library derived from normal human testis for antigens reacting with IgG antibodies in the 1 : 250 diluted sera of three patients with untreated GCA using SEREX, the serological identification of antigens by recombinant cDNA expression cloning. Of 100 000 clones screened with each serum, six, 28 and six clones, respectively, were positive, representing a total of 33 different antigens. Most of the antigens reacted only with the serum used for identification and/or at a similar frequency with normal control sera. However, lamin C and the nuclear antigen of 14 kD reacted specifically with 32% of GCA/PMR, but with none of the control sera, while human cytokeratin 15, mitochondrial cytochrome oxidase subunit II, and a new gene product were detected preferentially, but not exclusively by sera from GCA/PMR patients. We conclude that patients with GCA/PMR develop antibodies against a broad spectrum of human autoantigens. Antibodies against human lamin C, the nuclear autoantigen of 14 kD as well as human cytokeratin 15, mitochondrial cytochrome oxidase subunit II and the product of a new gene should be investigated further to determine their value as tools for the diagnosis and/or the definition of clinical subgroups of patients with GCA/PMR.

show abstract

Autoantibodies in hepatitis delta

Cited by 6 publications

References 42 publications

Hepatitis Delta Virus Detected in Salivary Glands of Sjögren’s Syndrome Patients and Recapitulates a Sjögren’s Syndrome-Like Phenotype in Vivo

Hepatitis Delta Virus Detected in Salivary Glands of Sjögren’s Syndrome Patients and Recapitulates a Sjögren’s Syndrome-Like Phenotype in Vivo

Autoantibodies as Prognostic Markers in Autoimmune Liver Disease

Analysis of the B cell repertoire against autoantigens in patients with giant cell arteritis and polymyalgia rheumatica

Contact Info

Product

Resources

About