Autoantibodies and Disease Activity in Patients With Discoid Lupus Erythematosus

Kim, Andrew; O’Brien, Jack C.; Tseng, Lin Chiang; Zhang, Song; Chong, Benjamin F.

doi:10.1001/jamadermatol.2013.8354

Cited by 12 publications

(7 citation statements)

References 4 publications

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“…The correlation of anti‐U1‐RNP antibodies with photosensitivity and the presence of DLE in SLE patients have been described before . Recently, a correlation between disease activity and level of anti‐RNP IgG was reported . Taking into consideration that anti‐ds‐DNA antibodies correlate moderately with disease activity, especially in renal involvement, our results could also implicate that patient with SLE and CLE may have a higher disease activity.…”

Section: Discussionsupporting

confidence: 78%

Cutaneous characteristics and association with antinuclear antibodies in 402 patients with different subtypes of lupus erythematosus

Patsinakidis

Gambichler

Lahner

et al. 2016

Acad Dermatol Venereol

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Section: Discussionsupporting

confidence: 78%

Cutaneous characteristics and association with antinuclear antibodies in 402 patients with different subtypes of lupus erythematosus

Patsinakidis

Gambichler

Lahner

et al. 2016

Acad Dermatol Venereol

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“…Serological studies are also frequently positive; however, antinuclear antibody is less sensitive in cases of isolated DLE than in cases of DLE with concomitant systemic involvement. 6 In cases where LPP and DLE are difficult to distinguish, CD123 immunohistochemical staining for plasmacytoid dendritic cells (PDC) may be helpful. The infiltrate of DLE tends to have >50% PDCs in the reticular dermis 7 with clustering of PDCs, usually >10.…”

Section: Discussionmentioning

confidence: 99%

Plasma Cell-Predominant Lichen Planopilaris

Frew¹,

Oaxaca²,

Habermehl³

et al. 2021

The American Journal of Dermatopathology

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:Lichen planopilaris (LPP) is a scarring alopecia that is characterized by a lichenoid interface infiltrate with follicular extension. We present a case of LPP composed predominantly of plasma cells in a 52-year-old man. The patient was originally diagnosed with scalp psoriasis 30 years before presentation. Punch biopsies performed at an outside institution 2 years before presentation revealed lymphocyte-predominant LPP. After referral to the senior author's institution due to inadequate response to therapy, biopsies demonstrated a robust, superficial, and deep lichenoid interface dermatitis composed predominantly of plasma cells. Immunohistochemical and special staining for CD138, MUM-1, kappa and lambda light chains, immunoglobulin G4, CD3, CD20, PAX5, CD5, CD7, CD4, CD8, CD43, CD123, Gram, Grocott's methenamine silver stain, treponemal antibody, colloidal iron, and Movat showed a scarring alopecia and were not supportive of a hematolymphoid, infectious, or autoimmune etiology. B-cell clonality studies were below the threshold needed for definitive diagnosis of a clonal process. Doxycycline and hydroxychloroquine were subsequently added to the patient's treatment regimen, leading to an improvement of symptoms. We present this case to bring awareness to this unusual feature and discuss its differential diagnosis.

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“…It was observed that multiple correlations of ANA, anti‐dsDNA, anti‐RNP and anti‐ssDNA IgG with systemic disease activity measures in all DLE, DLE+/ANA+, and DLE+/SLE+ patients. Thus, they highlighted associations of ANA, anti‐dsDNA, anti‐RNP, and anti‐ssDNA IgG with disease activity in DLE patients 18 …”

Section: Discussionmentioning

confidence: 99%

Demodex positive discoid lupus erythematosus: Is it a separate entity or an overlap syndrome?

Dursun

Durmaz

Oltulu

et al. 2020

Dermatologic Therapy

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Discoid lupus erythematosus (DLE) is a chronic inflammatory erythematous skin disease that can be triggered by several factors. Rosacea is another skin disease that causes facial redness and tenderness. Demodex mites have been reported in rosacea and DLE patients commonly in the literature. These two diseases can be seen concomitant, mimic each other clinically and share common possible etiologic factors. To assess demodex mite infestation in both clinical and histopathological findings in DLE patients. We retrospectively evaluated the files of 42 patients with DLE who had been diagnosed DLE based on clinical and histopathological findings between August 2018 and August 2019. Demodex positivity was detected 50% of patients (n = 21). Neutrophile percentages in the dermal and perivascular area were higher in the demodex positive patients (4.43%) than in the Demodex negative patients (2.19%). The intensity of demodex mites correlated positively with dermal neutrophile percentages. ANA was negative in 29 patients (69%) and positive in 13 patients (31%). Anti‐dsDNA was negative in serology and follicular plugging was positive in histopathology in all 42 patients (100%). This was a retrospective study. DLE and rosacea share common features in etiopathogenesis and clinical presentation. Inflammation and exacerbations caused by the demodex mites may increase the clinical severity of DLE. Although the position of demodex mites in DLE etiopathogenesis is not known exactly, the presence of high demodex in DLE patients has been determined. Standard skin surface biopsy can be a routine procedure for the evaluation of DLE patients in daily clinical practice.

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Autoantibodies and Disease Activity in Patients With Discoid Lupus Erythematosus

Cited by 12 publications

References 4 publications

Cutaneous characteristics and association with antinuclear antibodies in 402 patients with different subtypes of lupus erythematosus

Cutaneous characteristics and association with antinuclear antibodies in 402 patients with different subtypes of lupus erythematosus

Plasma Cell-Predominant Lichen Planopilaris

Demodex positive discoid lupus erythematosus: Is it a separate entity or an overlap syndrome?

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