Autoantibodies and depression

Iseme, Rosebella A.; McEvoy, Mark; Kelly, Brian; Agnew, Linda L.; Attia, John; Walker, Frederick R.

doi:10.1016/j.neubiorev.2014.01.008

Cited by 39 publications

(15 citation statements)

References 194 publications

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“…However there were some studies that showed no relevance between anti-RP antibodies and neuropsychiatric symptoms [ 19 , 33 , 34 ]. Iseme et al believed that anti-RP antibody could upregulate proinflammatory cytokines like interferon and could cause neuronal death via apoptosis, which was the underlying mechanism of neuropsychiatric symptoms [ 35 ]. Arnett et al found that anti-RP antibody was strongly influenced by certain MHC class II alleles which might suggest the underlying genetic mechanism [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations

Bai

Liu

Zhao

et al. 2016

Journal of Immunology Research

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Depressive and anxiety disorders are frequently observed in patients with Systemic Lupus Erythematosus (SLE). However, the underlying mechanisms are still unknown. We conducted this survey to understand the prevalence of depression and anxiety in SLE patients without major neuropsychiatric manifestations (non-NPSLE) and to explore the relationship between emotional disorders, symptoms, autoantibodies, disease activity, and treatments in SLE. 176 SLE patients were included, and SLE disease activity index (SLEDAI), Hamilton Depression Rating Scale (HAMD), and Hamilton Anxiety Rating Scale (HAMA) were recorded to evaluate their disease activity and emotional status. We found that depressive and anxiety disorders were common among SLE patients: 121 (68.8%) patients were in depression status while 14 (8.0%) patients could be diagnosed with depression. Accordingly, 101 (57.4%) were in anxiety status and 21 (11.9%) could be diagnosed with anxiety. Depression was associated with disease activity, and anxiety was associated with anti-P0 antibody, while both of them were associated with proteinuria. HAMA and HAMD scores were in strong positive correlation and they were independent risk factors of each other. We concluded that the high prevalence of depression and anxiety and the association between depression and SLE disease activity might reveal the covert damage of central nervous system in SLE. The role of anti-P0 antibody in SLE patients with emotional disorders warrants more researches.

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Section: Discussionmentioning

confidence: 99%

Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations

Bai

Liu

Zhao

et al. 2016

Journal of Immunology Research

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“…To date, most research has focused on pro-inflammatory cytokines and a few reviews also propose a direct link between autoantibodies and depression (20, 21). Studies investigating the presence of autoantibodies in depression have focused in those targeting peripheral organs like the thyroid and intracellular antigens such as antinuclear antibodies and ribosomal-P antibodies (21–25). During the past decade, it has become clear that NSAbs could cause severe neuropsychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

Neuronal Surface Autoantibodies in Neuropsychiatric Disorders: Are There Implications for Depression?

et al. 2017

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Autoimmune diseases are affecting around 7.6–9.4% of the general population. A number of central nervous system disorders, including encephalitis and severe psychiatric disorders, have been demonstrated to associate with specific neuronal surface autoantibodies (NSAbs). It has become clear that specific autoantibodies targeting neuronal surface antigens and ion channels could cause severe mental disturbances. A number of studies have focused or are currently investigating the presence of autoantibodies in specific mental conditions such as schizophrenia and bipolar disorders. However, less is known about other conditions such as depression. Depression is a psychiatric disorder with complex etiology and pathogenesis. The diagnosis criteria of depression are largely based on symptoms but not on the origin of the disease. The question which arises is whether in a subgroup of patients with depression, the symptoms might be caused by autoantibodies targeting membrane-associated antigens. Here, we describe how autoantibodies targeting membrane proteins and ion channels cause pathological effects. We discuss the physiology of these antigens and their role in relation to depression. Finally, we summarize a number of studies detecting NSAbs with a special focus on cohorts that include depression diagnosis and/or show depressive symptoms.

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“…In the setting of emerging knowledge of the role of inflammation in psychiatric disorders, 13, 14 we sought to investigate differences in depression and anxiety between these chronic disease groups with known differential risk for CNS inflammation. Using a matched analysis to eliminate confounding by sex and age, which have known associations with both SLE/MCTD 1 and depression/anxiety, 2 we specifically aimed to compare youth with SLE/MCTD and T1D with respect to: 1) prevalence of depression, suicidal ideation and anxiety symptoms; 2) rate of mental health treatment in those with symptoms; and, 3) association of depression and anxiety symptoms with disease-specific factors.…”

Section: Introductionmentioning

confidence: 99%

Identifying Differences in Risk Factors for Depression and Anxiety in Pediatric Chronic Disease: A Matched Cross-Sectional Study of Youth with Lupus/Mixed Connective Tissue Disease and Their Peers with Diabetes

Knight

Weiss

Morales

et al. 2015

The Journal of Pediatrics

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Objective Depression and anxiety are associated with poor clinical and psychosocial outcomes in youth with chronic disease. To investigate differences in risk factors for depression and anxiety, like central nervous system (CNS) involvement in systemic lupus erythematosus (SLE)/mixed connective tissue disease (MCTD), we compared SLE/MCTD youth to type 1 diabetes mellitus (T1D) peers. Study Design We conducted a cross-sectional study of 50 outpatient pairs, ages 8 years and above, matching SLE/MCTD and T1D subjects by sex and age group. We screened for depression, suicidal ideation and anxiety using the Patient Health Questionnaire 9 and the Screen for Childhood Anxiety Related Disorders, respectively. We collected parent-reported mental health treatment data. We compared prevalence and treatment rates between SLE/MCTD and T1D subjects, and identified disease-specific risk factors using logistic regression. Results Depression symptoms were present in 23%, suicidal ideation in 15% and anxiety in 27% of participants. Compared to T1D, SLE/MCTD subjects had lower adjusted rates of depression and suicidal ideation, yet poorer rates of mental health treatment (24% vs 53%). Non-white race/ethnicity and longer disease duration were independent risk factors for depression and suicidal ideation. Depression was associated with poor disease control in both groups, and anxiety with insulin pump use in T1D subjects. Conclusion Depression and anxiety are high and undertreated in SLE/MCTD and T1D youth. Focusing on risk factors such as race/ethnicity and disease duration may improve their mental health care. Further study of CNS and other disease-related factors may identify targets for intervention.

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Autoantibodies and depression

Cited by 39 publications

References 194 publications

Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations

Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations

Neuronal Surface Autoantibodies in Neuropsychiatric Disorders: Are There Implications for Depression?

Identifying Differences in Risk Factors for Depression and Anxiety in Pediatric Chronic Disease: A Matched Cross-Sectional Study of Youth with Lupus/Mixed Connective Tissue Disease and Their Peers with Diabetes

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