2005
DOI: 10.1094/mpmi-18-0570
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Autoactive Alleles of the Flax L6 Rust Resistance Gene Induce Non-Race-Specific Rust Resistance Associated with the Hypersensitive Response

Abstract: L6 is a nucleotide binding site-leucine rich repeat (NBS-LRR) gene that confers race-specific resistance in flax (Linum usitatissimum) to strains of flax rust (Melampsora lini) that carry avirulence alleles of the AvrL567 gene but not to rust strains that carry only the virulence allele. Several mutant and recombinant forms of L6 were made that altered either the methionine-histidine-aspartate (MHD) motif conserved in the NBS domain of resistance proteins or exchanged the short domain C-terminal to the LRR reg… Show more

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Cited by 117 publications
(108 citation statements)
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“…Thus, the HR in Bgh-pen mutant interactions may be due to the inactivity rather than direct recognition of Bgh effectors. A similar situation has been described in flax mutants that constitutively express resistance responses and where normally compatible flax rust infection (no gene-for-gene interaction) is stopped with the HR (Howles et al, 2005).…”
Section: What Are the Requirements For Mildew Adaptation?supporting
confidence: 54%
“…Thus, the HR in Bgh-pen mutant interactions may be due to the inactivity rather than direct recognition of Bgh effectors. A similar situation has been described in flax mutants that constitutively express resistance responses and where normally compatible flax rust infection (no gene-for-gene interaction) is stopped with the HR (Howles et al, 2005).…”
Section: What Are the Requirements For Mildew Adaptation?supporting
confidence: 54%
“…In addition to the conserved P-loop residues involved in nucleotide binding, the histidine residue of the MHD motif is involved in coordinating the β-phosphate of bound ADP, indicating involvement of this motif in NBS function 61 . The MHD motif is highly conserved among plant NBS-LRR proteins but is less prevalent in animal NBS-LRR proteins 60 . Activation of caspase-9 and formation of the 'apoptosome' seem to require binding of ATP to Apaf-1.…”
Section: The Function Of Nucleotide Bindingmentioning
confidence: 99%
“…A similar effect is shown by mutation of the MHD motif at the site of the aspartic acid residue of the flax L6 protein leading to spontaneous necroses. In this case, mutations in the nucleotide-binding regions (P loop) interacting with an elicitor (LRR domain) neutralize the receptor activity [56]. Generally, mutations in the NB and ARC2 subdomains are involved in the mechanism of autoactivation [55].…”
Section: The Nbs Domainmentioning
confidence: 99%
“…This is caused by the expression of the bacterial effector inserted into the viral genome in plant cells infected by the virus. As a result, the plant receptor RPP13, which conditions resistance to H. parasitica, becomes an inductor of the resistance response to viral invasion [56,84]. Interaction between S. lycopersicum and P. syringae allowed the description of the initiation of the resistance response by NBS-LRR receptors [84].…”
Section: The Role Of Nbs-lrr Proteins In Plant Innate Immunitymentioning
confidence: 99%