Auto-Donation in the
Management of Placenta Previa and Erythroblastosis in
a Pregnancy Complicated by Gerbich Iso-Immunization

Peddle, L.J.; Josephson, J.E.; Lawton, A.

doi:10.1159/000465952

Cited by 2 publications

(3 citation statements)

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“…boy. In marked contrast to reported exam ples of alloanti-Gerbich [2,5,6,12,20,23,27,33], the boy's autoantibody was capable of binding IgG and complement to the pa tient's own Gerbich-positive red cells. De struction of the child's red cells continued under a standard steroid regimen, but cell survival improved following splenectomy.…”

Section: Case Historycontrasting

confidence: 84%

“…Clinical hemo lytic disease of the newborn due to antiGerbich has not been reported [2,20,27,33], Development of anti-Gerbich following transfusion has been reported, with clinical manifestations confined to slight chills in one case [25], and severe febrile reactions in another [12]. When radioactively labelled Gerbich-positive cells were injected into a patient whose plasma contained an IgM anti-Gerbich, the survival curves were es sentially normal [38].…”

Section: Discussionmentioning

confidence: 99%

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Autoimmune Hemolytic Anemia Associated with Autoanti-Ge

Reynolds¹,

Vengelen‐Tyler²,

Morel³

1981

Vox Sanguinis

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The first reported example of autoimmune hemolytic anemia due to an autoanti-Gerbich is described. The patient’s red blood cells exhibited a strongly positive direct antiglobulin test with both IgG and complement antiglobulin reagents. The serum contained a potent antibody which produced agglutination of red blood cells as well as a positive indirect antiglobulin test. Treatment of the serum with 2-mercaptoethanol demonstrated that the antibody contained both IgG and IgM components. The serum antibody and the antibody eluted from the patient’s red blood cells had anti-Gerbich specificity. The patient’s cells typed as Gerbich-positive with saline-agglutinating anti-Gerbich sera. Of great interest was the fact that the patient’s mother also has acquired immune hemolytic anemia, but the IgG antibody in her serum and eluted from her red blood cells had anti-pdl specificity.

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Section: Case Historycontrasting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Autoimmune Hemolytic Anemia Associated with Autoanti-Ge

Reynolds¹,

Vengelen‐Tyler²,

Morel³

1981

Vox Sanguinis

View full text Add to dashboard Cite

show abstract

“…The storing of blood by obstetric patients was reported by Milles et al (5) and Peddle et al (6) and, since 1988, reports in the literature have increased in relation to autologous blood transfusion for avoidance of human immunodeficiency virus infection. Several studies have shown autologous blood storage during pregnancy to be relatively safe for both mother and fetus (7)(8)(9)(10)(11) and to be feasible and reasonable transfusion practice (12)(13)(14).…”

Section: Discussionmentioning

confidence: 93%