Auto-amor Reactive Cytotoxic T-cell Responses in B-Cell Non-Hodgkin's Lymphoma

Perambakam, Supriya; Amin, Kishore; Naresh, Kikkeri N.; Advani, Suresh H.; Nadkarni, Jayshree J.

doi:10.3109/10428199709068281

Cited by 3 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More specifically, cancer vaccination would benefit from the identification of novel specific tumor antigens (74). Ex vivo generation of specific autologous CTL has proven difficult for the relatively low TILs frequency, their poor intrinsic cytotoxic activity, and their sophisticated culture conditions (12,13,69,75,76). Therefore, a need for the identification of novel effectors of the anti-lymphoma immune response still remains.…”

Section: Discussionmentioning

confidence: 99%

Synthetic Phosphoantigens Enhance Human Vγ9Vδ2 T Lymphocytes Killing of Non-Hodgkin’s B Lymphoma

Sicard

Saati

Delsol

et al. 2001

Mol Med

View full text Add to dashboard Cite

Background: Non-Hodgkin's B lymphomas (NHL) are often resistant to conventional treatments and, until now, immunotherapeutic approaches against NHL only aimed at inducing ␣␤ anti-tumor effectors. Nevertheless, human blood V␥9V␦2 T lymphocytes represent an abundant pool of cytotoxic tumor-reactive cells. V␥9V␦2 T cells are strongly activated by natural compounds, from which powerful synthetic ligands have been derived. These synthetic antigens induce efficient V␥9V␦2 T cell responses in vitro. Materials and Methods: We set up a series of V␥9V␦2 T cell-activation experiments, including cytotoxic activity and amplification from whole blood cells. Several types of V␥9V␦2 effectors were challenged against a panel of 16 B lymphoma cell lines. These tests have been performed in the absence and presence of ␥␦-specific synthetic ligands to evaluate the effect of such molecules on ␥␦ anti-tumor activity.

show abstract

Section: Discussionmentioning

confidence: 99%

Synthetic Phosphoantigens Enhance Human Vγ9Vδ2 T Lymphocytes Killing of Non-Hodgkin’s B Lymphoma

Sicard

Saati

Delsol

et al. 2001

Mol Med

View full text Add to dashboard Cite

show abstract

“…There are only few data published on the reactive lymphocyte population in cutaneous B‐cell lymphomas, although the topic has been intensively studied in nodal lymphomas 11–13 …”

Section: Discussionmentioning

confidence: 99%

Tumor‐infiltrating T cells in primary cutaneous B‐cell lympho‐proliferative disorders

Kamarashev¹,

Schaerer²,

Burg³

et al. 2001

J Cutan Pathol

View full text Add to dashboard Cite

show abstract

Intra-tumoral cytolytic cells: Pattern of distribution in B-cell non Hodgkin’s lymphoma

Perambakam

Naresh

Nerurkar

et al. 2000

Pathol. Oncol. Res.

View full text Add to dashboard Cite

Non-Hodgkin s lymphomas (NHLs) constitute a heterogeneous group of lymphoid neoplasms and a majority of them in India are of B-cell phenotype. Varying numbers of T lymphocytes and natural killer (NK) cells are consistently present within the lymph nodes (LNs). The role of these reactive cells is becoming understood. TIA-1 is a cytotoxic granule associated RNA binding protein, the expression of which is restricted to cytotoxic T lymphocytes (CTLs) and NK cells. Snap frozen lymph node biopsies obtained from 41 B-cell NHLs were localized for intra-tumoral TIA-1 + cytolytic cells by immunohistochemistry. Distribution of T cell subsets and NK cells were also quantified. Cells expressing TIA-1 antigen was observed in all the cases, seen as a strong granular cytoplasmic signal. Results indicate significantly higher number of TIA-1 cytolytic cells outside (periphery of the follicle and interfollicular areas) than within the neoplastic follicle in follicular lymphomas (p<0.001). In small lymphocytic lymphomas, cytolytic cells were mainly seen as uniformly scattered single cells, distributed throughout the tumor environment. In mantle cell and diffuse large B-cell lymphomas these were most often seen as small clusters and less frequently as singly scattered cells. Higher numbers of CD4 + than the CD8 + T cells were observed in most cases. Contrary to the follicles in follicular hyperplasia, CD57 + NK cells were predominantly observed outside the neoplastic follicle in follicular lymphomas (FLs). These results outline specific interactions between the potential anti-tumoral cytolytic and the malignant cells of B-cell NHLs.

show abstract

Auto-amor Reactive Cytotoxic T-cell Responses in B-Cell Non-Hodgkin's Lymphoma

Cited by 3 publications

References 14 publications

Synthetic Phosphoantigens Enhance Human Vγ9Vδ2 T Lymphocytes Killing of Non-Hodgkin’s B Lymphoma

Synthetic Phosphoantigens Enhance Human Vγ9Vδ2 T Lymphocytes Killing of Non-Hodgkin’s B Lymphoma

Tumor‐infiltrating T cells in primary cutaneous B‐cell lympho‐proliferative disorders

Intra-tumoral cytolytic cells: Pattern of distribution in B-cell non Hodgkin’s lymphoma

Contact Info

Product

Resources

About