Autistic traits in first‐episode psychosis: Rates and association with 1‐year recovery outcomes

Zheng, Shushan; Chua, Yi Chian; Tang, Charmaine; Tan, Giles Ming Yee; Abdin, Edimansyah; Lim, Vicki; Koh, Astelle; Verma, Swapna; Magiati, Iliana

doi:10.1111/eip.13021

Cited by 13 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stereotype endorsement and difficulty in communication skills indirectly affected recovery via depressive symptoms. Several recent studies have shown autistic traits in patients with psychotic disorders, including first-episode psychosis, which has been associated with poor recovery outcomes and social functioning [19,20,34]. Considering these previous findings and the results of our study, selfstigma and depression may partially be related to the association between high levels of autistic traits in patients with psychosis and poor recovery-related outcomes and social functioning.…”

Section: Discussionsupporting

confidence: 80%

“…"I do not think so" to 4. "I very much think so," and five subscales (alienation [1,5,8,16,17,21], stereotype endorsement [2,6,10,18,19,23,24], perceived discrimination [3,15,22,25,26], social withdrawal [4,9,[11][12][13]20], and stigma resistance [7,14,[27][28][29]). The average ISMI score is interpreted as follows: 1.00-2.00, no or very mild self-stigma; 2.01-2.50, a mild level of self-stigma; 2.51-3.00, a moderate level of self-stigma; and 3.01-4.00, a severe level of self-stigma.…”

Section: Assessment Of Self-stigmamentioning

confidence: 99%

“…In a recent meta-analysis, higher levels of autistic symptoms in patients with schizophrenia-spectrum disorders were identified compared with healthy controls [18]. Furthermore, higher levels of autistic traits have recently been associated with poorer social functioning in patients with psychosis, and autism spectrum traits have been found to be predictors of 1-year poor recovery outcomes in patients with a first-episode psychosis [19,20].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mediating effects of self-stigma and depression on the association between autistic symptoms and recovery in patients with schizophrenia-spectrum disorders: a cross-sectional study

et al. 2021

View full text Add to dashboard Cite

Background Several studies have indicated that self-stigma is associated with depressive symptoms and could be a barrier to recovery in patients with schizophrenia-spectrum disorders. More recently, an association between autistic symptoms and self-stigma was found in schizophrenia-spectrum patients. This study aimed to investigate the association between self-stigma, autistic and depressive symptoms, and recovery in patients with schizophrenia. Methods In total, 105 participants were evaluated using the Autism Spectrum Quotient, the Internalized Stigma of Mental Illness Scale, the Quick Inventory of Depressive Symptomatology, and the Recovery Assessment Scale to investigate autistic symptoms, self-stigma, depressive symptoms, and recovery, respectively. The relationship between self-stigma, autistic symptoms, depressive symptoms, and recovery was assessed using structural equation modeling analysis. Results Impaired attention switching, one symptom of autism, was found to positively affect stereotype endorsement, which negatively influenced recovery through depressive symptoms. Moreover, problems with communication skills negatively affected recovery through depressive symptoms. Concerning self-stigma, stereotype endorsement and perceived discrimination had a negative effect on recovery through depressive symptoms, whereas stigma resistance had a direct negative effect on recovery. Conclusions This study may provide meaningful insight into the psychological structure of recovery and could inform effective interventions for patients with schizophrenia-spectrum disorders. This was a cross-sectionally designed study; therefore, further longitudinal studies are needed to identify the causal relationships between self-stigma, autistic and depressive symptoms, and recovery.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Assessment Of Self-stigmamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mediating effects of self-stigma and depression on the association between autistic symptoms and recovery in patients with schizophrenia-spectrum disorders: a cross-sectional study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Zheng et al (2020) found that, at baseline, more ASD traits among FEP patients were associated with a greater likelihood of having “psychosis, not otherwise specified,” “mood disorder with psychotic features,” or “brief psychotic disorder” diagnoses, rather than a schizophrenia diagnosis. At 1 year follow‐up, more ASD traits in the same FEP group predicted lesss improvement in severity of psychotic symptoms or level of functioning.…”

Section: Resultsmentioning

confidence: 99%

Autism spectrum disorder and schizophrenia: An updated conceptual review

2021

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) and schizophrenia (SCZ) are separate disorders, with distinct clinical profiles and natural histories. ASD, typically diagnosed in childhood, is characterized by restricted or repetitive interests or behaviors and impaired social communication, and it tends to have a stable course. SCZ, typically diagnosed in adolescence or adulthood, is characterized by hallucinations and delusions, and tends to be associated with declining function. However, youth with ASD are three to six times more likely to develop SCZ than their neurotypical counterparts, and increasingly, research has shown that ASD and SCZ converge at several levels. We conducted a systematic review of studies since 2013 relevant to understanding this convergence, and present here a narrative synthesis of key findings, which we have organized into four broad categories: symptoms and behavior, perception and cognition, biomarkers, and genetic and environmental risk. We then discuss opportunities for future research into the phenomenology and neurobiology of overlap between ASD and SCZ. Understanding this overlap will allow for researchers, and eventually clinicians, to understand the factors that may make a child with ASD vulnerable to developing SCZ. Lay Summary Autism spectrum disorder and schizophrenia are distinct diagnoses, but people with autism and people with schizophrena share several characteristics. We review recent studies that have examined these areas of overlap, and discuss the kinds of studies we will need to better understand how these disorders are related. Understanding this will be important to help us identify which autistic children are at risk of developing schizophrenia.

show abstract

“…There is limited data regarding autistic features in FEP and schizophrenia (Chisholm et al, 2019; Deste et al, 2018; Kästner et al, 2015; Zheng et al, 2021). Previous reports shed light on common clinical features in autism and schizophrenia although they are distinct clinical conditions.…”

Section: Discussionmentioning

confidence: 99%

Autistic features and executive functions in first episode psychosis: Associations with functionality and quality of life

Davut

Durmaz

Güleç

2023

Early Intervention Psych

View full text Add to dashboard Cite

AimThe present study aimed at investigating the relationships between autistic features and cognitive deficits, functionality and quality of life in first episode psychosis (FEP) patients.MethodsSixty FEP patients [mean age (SD) = 32.53 (10.74), n = 23 female, n = 37 male] were enrolled in this cross‐sectional study. Data was collected using a sociodemographic and clinical data form, the Positive and Negative Syndrome Scale (PANSS), the PANSS Autism Severity Score (PAUSS), the Personal and Social Performance Scale (PSP), the Frontal Assessment Battery (FAB), and the World Health Organization Quality of Life Scale Short Form in Turkish Version (WHOQOL‐BREF TR).ResultsAutistic symptom severity was found to be higher in males than females, and higher in patients with a family history of psychotic disorder. An inverse relationship was found between the duration of education and the severity of autistic symptoms. While there was an inverse relationship between autistic symptom severity and executive functions and functionality, no significant correlation was found with quality of life. Negative symptom severity was a predictor of executive functions and functionality. No significant difference was observed between autistic and psychotic domains which were related to executive functions.ConclusionsOur study is the first to examine the relationship between autistic/psychotic symptoms and executive functions and functionality in patients with FEP. The results show that autistic symptoms are associated with worse social and personal functioning and worse executive functions in patients with FEP. Longitudinal follow‐up studies with larger samples are required to determine the direction of the relations.

show abstract

Autistic traits in first‐episode psychosis: Rates and association with 1‐year recovery outcomes

Cited by 13 publications

References 21 publications

Mediating effects of self-stigma and depression on the association between autistic symptoms and recovery in patients with schizophrenia-spectrum disorders: a cross-sectional study

Mediating effects of self-stigma and depression on the association between autistic symptoms and recovery in patients with schizophrenia-spectrum disorders: a cross-sectional study

Autism spectrum disorder and schizophrenia: An updated conceptual review

Autistic features and executive functions in first episode psychosis: Associations with functionality and quality of life

Contact Info

Product

Resources

About