2012
DOI: 10.1038/nature11310
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Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

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Cited by 806 publications
(951 citation statements)
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References 39 publications
(52 reference statements)
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“…Indeed, many cell-signalling pathways are under investigation in relation to ASDs, especially the ones that have already been much studied for their synaptic functions [13 -16]. Suspected brain regions also are widely diverse and range from the prefrontal cortex to cerebellum [17,18].…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, many cell-signalling pathways are under investigation in relation to ASDs, especially the ones that have already been much studied for their synaptic functions [13 -16]. Suspected brain regions also are widely diverse and range from the prefrontal cortex to cerebellum [17,18].…”
Section: Introductionmentioning
confidence: 99%
“…Similarly deviant vocalizations have also been observed in Fmr1‐ and Tsc1‐ deficient pups, therefore our results contribute to a consistency of communication deficits found across several mTOR models (Reynolds et al., 2016; Tsai et al., 2012; Young, Schenk, Yang, Jan, & Jan, 2010). Specifically, Fmr1 KO pups were shown to emit significantly fewer vocalizations than their WT counterparts when separated from their mother (Reynolds et al., 2016).…”
Section: Discussionmentioning
confidence: 99%
“…Specifically, Fmr1 KO pups were shown to emit significantly fewer vocalizations than their WT counterparts when separated from their mother (Reynolds et al., 2016). In contrast, Tsc1 HT pups emitted significantly more vocalizations than their controls (Tsai et al., 2012). Thus, while the particular quantity of vocalizations emitted is not always constant across different mTOR models, the underlying aberrant vocalizing patterns are still observed, demonstrating a consistency between our findings and those in related studies.…”
Section: Discussionmentioning
confidence: 99%
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