Autistic enterocolitis: is it a histopathological entity?

A sibling-paired observational study investigating the accumulation and deficiency of toxic and essential elements in children with autism spectrum disorders

“…Some groups have implicated factors such as early childhood development during periods of excessive rain (with associated increased television watching) as a factor in the prevalence and development of the ASDs (Waldman et al, 2008;Weiss et al, 2008;Guidotti, 2005). This age range has seen a substantial amount of work and theories include those regarding autoimmunity (Ashwood et al, 2004;Ashwood et al, 2006;Wills et al, 2007;Schmitz and Rezaie, 2008), viral infections (Libbey et al, 2005), vitamin D deficiency (Cannell, 2008), use of measlesmumps-rubella (MMR) vaccines (Hilton et al, 2006;Gerber and Offit, 2009;Doja, 2006;Wakefield et al, 1998f, leaky gut syndromes Gohnson, 2006MacDonald et al, 2007;Christison and lvany, 2006), oxidative stress due to reduced anti-oxidant capacity and activities (Ng et al, 2008;Kern and Jones, 2006) and as related to this study, metal exposure (section 1.3.3). The epidemiological data on autism's prevalence has indicated that diagnoses of ASDs has been increasing over the years (Fombonne, 1999;Fombonne, 2002;Lotter, 1966;van den Hazel, 2008); although, this phenomenon is generally regarded as due to better and more rigorous diagnostic criteria (thus indicating a potential for more diagnosis of the condition) (Green et al, 2003;Benaron, 2009).…”

“…In regards to metal/ element deficiencies at the post-natal level, this is a common finding in children with ASD. Children with ASD are known to be susceptible to digestive problems (Kerwin et al, 2005;Liu et al, 2005;Levy et al, 2007;Nikolov et al, 2009) and several alternative therapies center around the exclusion of foods that contain such ingredients as gluten and casein (in particular to combination of the two exclusions resulting in a generally prescribed gluten-casein free diet) which follow largely the issues with the intestinal tract and possible leaky gut observed in children with ASD (Johnson, 2006;MacDonald et al, 2007;Christison and Ivany, 2006). This issue has been evaluated by several groups who have noted that several factors influence the ultimate dietary status of autistic children.…”

A sibling-paired observational study investigating the accumulation and deficiency of toxic and essential elements in children with autism spectrum disorders

“…Some groups have implicated factors such as early childhood development during periods of excessive rain (with associated increased television watching) as a factor in the prevalence and development of the ASDs (Waldman et al, 2008;Weiss et al, 2008;Guidotti, 2005). This age range has seen a substantial amount of work and theories include those regarding autoimmunity (Ashwood et al, 2004;Ashwood et al, 2006;Wills et al, 2007;Schmitz and Rezaie, 2008), viral infections (Libbey et al, 2005), vitamin D deficiency (Cannell, 2008), use of measlesmumps-rubella (MMR) vaccines (Hilton et al, 2006;Gerber and Offit, 2009;Doja, 2006;Wakefield et al, 1998f, leaky gut syndromes Gohnson, 2006MacDonald et al, 2007;Christison and lvany, 2006), oxidative stress due to reduced anti-oxidant capacity and activities (Ng et al, 2008;Kern and Jones, 2006) and as related to this study, metal exposure (section 1.3.3). The epidemiological data on autism's prevalence has indicated that diagnoses of ASDs has been increasing over the years (Fombonne, 1999;Fombonne, 2002;Lotter, 1966;van den Hazel, 2008); although, this phenomenon is generally regarded as due to better and more rigorous diagnostic criteria (thus indicating a potential for more diagnosis of the condition) (Green et al, 2003;Benaron, 2009).…”

Pathology reports solve "new bowel disease" riddle

“…32 "They had to create a new disease, and when Susan Davies got normal results they were in trouble," argues Tom MacDonald, a gastrointestinal immunologist and dean of research at Barts and the London school of medicine. He has published on Wakefield's findings with Domizio, 33 and both have consulted for vaccine manufacturers, inspecting some of the biopsy slides. "If there wasn't IBD [inflammatory bowel disease], then Wakefield's whole theory collapsed, and with it the litigation which was paying him.…”