Autistic disorders in Down syndrome: background factors and clinical correlates

Rasmussen, Peder; Börjesson, Ola; Wentz, Elisabet; Gillberg, Christopher

doi:10.1111/j.1469-8749.2001.tb00156.x

Cited by 24 publications

(28 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1). Tentative diagnosis reflected the reality facing clinicians, as sometimes it is difficult to diagnose autism in young children, for instance when they also have a substantial developmental delay and/or a medical condition/syndrome, and/or when the results of diagnostic instruments do not converge (Lord, 1995;Nordin & Gillberg, 1996;Rasmussen, Bö rjesson, Wentz, & Gillberg, 2001). It has been suggested that in cases of suspected autism no children below 3 years of age should receive other than a tentative PDD diagnosis, which should be reviewed when they are 5-6 years of age (Szatmari, 2003).…”

Section: Discussionmentioning

confidence: 99%

Follow-up of Children Diagnosed with Pervasive Developmental Disorders: Stability and Change During the Preschool Years

Jónsdóttir

Sæmundsen

Ásmundsdóttir

et al. 2006

J Autism Dev Disord

View full text Add to dashboard Cite

Forty-one children with pervasive developmental disorders (PDDs) receiving eclectic services were assessed twice during their preschool years. Measures were compared over time for the whole group and for diagnostic subgroups: Childhood autism (CA group) and Other PDDs group. The mean intelligence quotient/developmental quotient (IQ/DQ) of the whole group was stable (P = 0.209) and scores on the Childhood Autism Rating Scale (CARS) decreased (P = 0.001). At time 2, the CA group was more impaired than the other PDDs group: autistic symptoms were more severe (P = 0.01), adaptive behavior scores were lower (P = 0.014), and a trend for lower IQ/DQs (P = 0.06). Children in this study seemed to fare better than reported in previous follow-up studies on children with autism.

show abstract

Section: Discussionmentioning

confidence: 99%

Follow-up of Children Diagnosed with Pervasive Developmental Disorders: Stability and Change During the Preschool Years

Jónsdóttir

Sæmundsen

Ásmundsdóttir

et al. 2006

J Autism Dev Disord

View full text Add to dashboard Cite

show abstract

“…Children with Down syndrome and ASD had lower IQ's, and more severe, odd stereotypic behaviors, anxiety, and social withdrawal. Others find that risk factors for autism in children with Down syndrome include such medical conditions as seizures, early hypothyroidism, postcardiac surgery complications, as well as having lower IQ's and first or second degree relatives with ASD or with the broader autism phenotype [Ghaziuddin, 2000;Rasmussen et al, 2001;Starr et al, 2005].…”

Section: Childrenmentioning

confidence: 97%

Psychiatric and behavioral disorders in persons with Down syndrome

Dykens

2007

Ment. Retard. Dev. Disabil. Res. Rev.

208

150

View full text Add to dashboard Cite

Similar to the state of the broader intellectual disabilities field, many gaps exist in the research and treatment of mental health concerns in people with Down syndrome. This review summarizes key findings on the type and prevalence of behavior and emotional problems in children, adolescents, and adults with Down syndrome. Such findings include relatively low rates of severe problems in children, and well-documented risks of depression and Alzheimer's disease in older adults. The review also considers emerging data on autism, and the paucity of studies on adolescents. Three next steps for research are highlighted, including a need to: (1) connect research on psychiatric status and diagnoses across developmental periods, including adolescence, and to examine such associated processes as sociability, anxiety and attention; (2) unravel complicated biopsycho-social risk and protective factors that serve to increase or diminish psychopathology; and (3) identify evidence-based treatments that both reduce distressful symptoms and enhance well-being in individuals with Down syndrome.

show abstract

“…4,5 Autism is also being diagnosed with increasing frequency in individuals with Down syndrome. 6,7 This co-occurrence has been reported to occur at a rate of at least 7% in individuals with Down syndrome. 8 However, because of the developmental delays that are inherent with a diagnosis of Down syndrome, practitioners may be hesitant to make the second diagnosis of autism even when full diagnostic criteria for autism have been met.…”

mentioning

confidence: 96%

Difference in Age at Regression in Children with Autism with and without Down Syndrome

Castillo¹,

Patterson²,

Hickey³

et al. 2008

Journal of Developmental &Amp; Behavioral Pediatrics

View full text Add to dashboard Cite

Objective: Autism occurs more frequently in individuals with Down syndrome than it does in the general population. Among children with autism and Down syndrome, regression is reported to occur in up to 50%. The aim of this study was to characterize and compare regression in children with autism with and without Down syndrome. Methods: In this case-control study, children with Down syndrome and autism characterized by a history of developmental regression (n ‫؍‬ 12) were compared to children with autism with regression who did not have Down syndrome, matched for chronologic age and gender. Comparisons were made on age at acquisition of language and age at loss of language and other skills as measured by the Autism Diagnostic Interview-Revised (ADI-R). Results: The mean age at acquisition of meaningful use of single words was 40.6 months (SD ‫؍‬ 38.0) in children with Down syndrome and autism compared to 14.9 months (SD ‫؍‬ 8.5) in children with autism without Down syndrome (p ‫؍‬ .005). The mean age at language loss in children with autism with Down syndrome was 61.8 months (SD ‫؍‬ 22.9) compared to 19.7 months (SD ‫؍‬ 5.8) for those with autism without Down syndrome (p ‫؍‬ .01). The mean age at other skill loss was 46.2 months (SD ‫؍‬ 19.1) and 19.5 months (SD ‫؍‬ 5.6), respectively (p ‫؍‬ .006). Conclusions: When regression occurs in children with autism and Down syndrome it is, on average, much later than is typically seen in children with autism without Down syndrome. (J Dev Behav Pediatr 29:89-93, 2008)

show abstract

Autistic disorders in Down syndrome: background factors and clinical correlates

Cited by 24 publications

References 18 publications

Follow-up of Children Diagnosed with Pervasive Developmental Disorders: Stability and Change During the Preschool Years

Follow-up of Children Diagnosed with Pervasive Developmental Disorders: Stability and Change During the Preschool Years

Psychiatric and behavioral disorders in persons with Down syndrome

Difference in Age at Regression in Children with Autism with and without Down Syndrome

Contact Info

Product

Resources

About