Autism, the superior temporal sulcus and social perception

Zilbovicius, Mônica; Meresse, Isabelle; Chabane, Nadia; Brunelle, Françis; Samson, Yves; Boddaert, Nathalie

doi:10.1016/j.tins.2006.06.004

Cited by 325 publications

(232 citation statements)

References 53 publications

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“…This hypothesis is consistent with previous reports (Price, 2010) that this region is specifically activated during sentence comprehension, when consecutive words are integrated into a coherent story and not for single, isolated words. The MTG cluster included the superior temporal sulcus, which is associated with social cognition, and dysfunctional in autism (Zilbovicius et al, 2006). Our interpretation is that MTG plays a central role in elaborating little scenarios, on a visual basis, that naturally take place when understanding concrete sentences describing people's actions (Redcay, 2008).…”

Section: Discussionmentioning

confidence: 79%

Long-Distance Amplitude Correlations in the High Gamma Band Reveal Segregation and Integration within the Reading Network

Vidal¹,

Freyermuth²,

Jerbi³

et al. 2012

J. Neurosci.

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Reading sentences involves a distributed network of brain regions acting in concert surrounding the left sylvian fissure. The mechanisms of neural communication underlying the extraction and integration of verbal information across subcomponents of this reading network are still largely unknown. We recorded intracranial EEG activity in 12 epileptic human patients performing natural sentence reading and analyzed long-range corticocortical interactions between local neural activations. During a simple task contrasting semantic, phonological, and purely visual processes, we found process-specific neural activity elicited at the single-trial level, characterized by energy increases in a broad gamma band (40 -150 Hz). Correlation analysis between task-induced gamma-band activations revealed a selective fragmentation of the network into specialized subnetworks supporting sentence-level semantic analysis and phonological processing. We extend the implications of our results beyond reading, to propose that gamma-band amplitude correlations might constitute a fundamental mechanism for large-scale neural integration during high-level cognition.

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Section: Discussionmentioning

confidence: 79%

Long-Distance Amplitude Correlations in the High Gamma Band Reveal Segregation and Integration within the Reading Network

Vidal¹,

Freyermuth²,

Jerbi³

et al. 2012

J. Neurosci.

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“…As hippocampus and its related structure are involved in memory consolidation (Nadel & Moscovitch, 1997), cerebral GM volume reduction in hippocampus and parahippocampal gyrus might account for memory loss in both svMCI patients and SVaD patients. In addition, superior temporal gyrus is proven to be related with social interaction and cognition process (e.g., visual perception and integration, voice and auditory perception, and even thinking process) (Zilbovicius et al, 2006), which is crucial for the function of language. Thus, cerebral GM volume reduction in superior temporal gyrus might result in language dysfunction in both svMCI patients and SVaD patients.…”

Section: Discussionmentioning

confidence: 99%

Cerebral gray matter volume reduction in subcortical vascular mild cognitive impairment patients and subcortical vascular dementia patients, and its relation with cognitive deficits

Meng

Wang

et al. 2017

Brain and Behavior

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“…This neocortical region was chosen because it hosts welldocumented structural and functional abnormalities in autism. 42 These tissue samples largely overlap with those employed in our recent study of the MET pathway. 5 Clinical and demographic information, family history and autopsy reports were obtained from the Autism Tissue Program web site (www.…”

Section: Patient Brain Tissue Informationmentioning

confidence: 99%

Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression

et al. 2008

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Protein kinase C enzymes play an important role in signal transduction, regulation of gene expression and control of cell division and differentiation. The fsI and bII isoenzymes result from the alternative splicing of the PKCb gene (PRKCB1), previously found to be associated with autism. We performed a family-based association study in 229 simplex and 5 multiplex families, and a postmortem study of PRKCB1 gene expression in temporocortical gray matter (BA41/42) of 11 autistic patients and controls. PRKCB1 gene haplotypes are significantly associated with autism (P < 0.05) and have the autistic endophenotype of enhanced oligopeptiduria (P < 0.05). Temporocortical PRKCB1 gene expression was reduced on average by 35 and 31% for the PRKCB1-1 and PRKCB1-2 isoforms (P < 0.01 and < 0.05, respectively) according to qPCR. Protein amounts measured for the PKCbII isoform were similarly decreased by 35% (P = 0.05). Decreased gene expression characterized patients carrying the 'normal' PRKCB1 alleles, whereas patients homozygous for the autism-associated alleles displayed mRNA levels comparable to those of controls. Whole genome expression analysis unveiled a partial disruption in the coordinated expression of PKCb-driven genes, including several cytokines. These results confirm the association between autism and PRKCB1 gene variants, point toward PKCb roles in altered epithelial permeability, demonstrate a significant downregulation of brain PRKCB1 gene expression in autism and suggest that it could represent a compensatory adjustment aimed at limiting an ongoing dysreactive immune process. Altogether, these data underscore potential PKCb roles in autism pathogenesis and spur interest in the identification and functional characterization of PRKCB1 gene variants conferring autism vulnerability.

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Autism, the superior temporal sulcus and social perception

Cited by 325 publications

References 53 publications

Long-Distance Amplitude Correlations in the High Gamma Band Reveal Segregation and Integration within the Reading Network

Long-Distance Amplitude Correlations in the High Gamma Band Reveal Segregation and Integration within the Reading Network

Cerebral gray matter volume reduction in subcortical vascular mild cognitive impairment patients and subcortical vascular dementia patients, and its relation with cognitive deficits

Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression

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