Autism Symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial Trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders

Mulligan, Aisling; Anney, Richard; O’Regan, Myra; Chen, Wai; Butler, Louise; Fitzgerald, Michael; Buitelaar, Jan; Steinhausen, Hans-Christoph; Rothenberger, Aribert; Minderaa, Ruud B.; Nijmeijer, Judith S.; Hoekstra, Pieter J.; Oades, Robert D.; Roeyers, Herbert; Buschgens, Cathelijne J. M.; Christiansen, Hanna; Franke, Barbara; Gabriëls, Isabel; Hartman, Catharine A.; Kuntsi, Jonna; Marco, Rafaela; Meidad, Sheera; Müller, Urs; Psychogiou, Lamprini; Rommelse, Nanda; Thompson, Margaret; Uebel, Henrik; Banaschewski, Tobias; Ebstein, Richard P.; Eisenberg, Jacques; Manor, Iris; Miranda, Ana; Mulas, Fernando; Sergeant, Joseph A.; Sonuga‐Barke, Edmund; Asherson, Philip; Faraone, Stephen V.; Gill, Michael

doi:10.1007/s10803-008-0640-0

Cited by 40 publications

(67 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fewer studies have examined the occurrence of autistic symptoms in persons with ADHD because most studies of ADHD tend to exclude subjects with autism and/or intellectual disability. While exact figures are difficult to estimate, a large number of children with ADHD also present with symptoms of ASD [8, 9]. In addition to the comorbidity between the two conditions, reports have also suggested a possible overlap in their symptoms [7].…”

Section: Introductionmentioning

confidence: 99%

Neuropsychological Characteristics of Children with Mixed Autism and ADHD

Colombi

Ghaziuddin

2017

Autism Research and Treatment

View full text Add to dashboard Cite

Clinical heterogeneity is a well-established characteristic of autism spectrum disorder (ASD). While the comorbidity of ASD and ADHD is well known in clinical practice, relatively little research has examined the neuropsychological profile of children with ASD + ADHD. Our study showed significant differences in the neuropsychological characteristics of children with ASD + ADHD compared to those with ASD only. Children with ASD + ADHD showed higher symptoms of anxiety, worse working memory, and less empathy, as measured by the “Reading the Mind in the Eyes.” This suggests that having ADHD brings further challenges to individuals with ASD and may negatively impact their management and outcome. Our findings may have implications for clinical assessment as well as for intervention.

show abstract

Section: Introductionmentioning

confidence: 99%

Neuropsychological Characteristics of Children with Mixed Autism and ADHD

Colombi

Ghaziuddin

2017

Autism Research and Treatment

View full text Add to dashboard Cite

show abstract

“…Most previous research has used parent reports of mental health and peer difficulties. Only one study19 has included teacher reports of externalising symptoms, finding that greater ASD symptoms were associated with more externalising symptoms, and no studies have included teacher ratings of internalising symptoms or peer problems. Teachers may be better able to rate peer, emotional and conduct problems, as well as prosocial behaviour, given that they regularly observe children within a social context of same-aged peers.…”

Section: Introductionmentioning

confidence: 99%

Association between autism symptoms and functioning in children with ADHD

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Furthermore, a score measuring prosocial behaviour can be derived from the SDQ. This score in combination with the Social Communications Questionnaire [21], is used in screening for autism spectrum disorders as autistic features are frequently associated with ADHD [22,23]. …”

Section: Introductionmentioning

confidence: 99%

The impact of study design and diagnostic approach in a large multi-centre ADHD study: Part 2: Dimensional measures of psychopathology and intelligence

et al. 2011

Self Cite

View full text Add to dashboard Cite

BackgroundThe International Multi-centre ADHD Genetics (IMAGE) project with 11 participating centres from 7 European countries and Israel has collected a large behavioural and genetic database for present and future research. Behavioural data were collected from 1068 probands with ADHD and 1446 unselected siblings. The aim was to describe and analyse questionnaire data and IQ measures from all probands and siblings. In particular, to investigate the influence of age, gender, family status (proband vs. sibling), informant, and centres on sample homogeneity in psychopathological measures.MethodsConners' Questionnaires, Strengths and Difficulties Questionnaires, and Wechsler Intelligence Scores were used to describe the phenotype of the sample. Data were analysed by use of robust statistical multi-way procedures.ResultsBesides main effects of age, gender, informant, and centre, there were considerable interaction effects on questionnaire data. The larger differences between probands and siblings at home than at school may reflect contrast effects in the parents. Furthermore, there were marked gender by status effects on the ADHD symptom ratings with girls scoring one standard deviation higher than boys in the proband sample but lower than boys in the siblings sample. The multi-centre design is another important source of heterogeneity, particularly in the interaction with the family status. To a large extent the centres differed from each other with regard to differences between proband and sibling scores.ConclusionsWhen ADHD probands are diagnosed by use of fixed symptom counts, the severity of the disorder in the proband sample may markedly differ between boys and girls and across age, particularly in samples with a large age range. A multi-centre design carries the risk of considerable phenotypic differences between centres and, consequently, of additional heterogeneity of the sample even if standardized diagnostic procedures are used. These possible sources of variance should be counteracted in genetic analyses either by using age and gender adjusted diagnostic procedures and regional normative data or by adjusting for design artefacts by use of covariate statistics, by eliminating outliers, or by other methods suitable for reducing heterogeneity.

show abstract

Autism Symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial Trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders

Cited by 40 publications

References 0 publications

Neuropsychological Characteristics of Children with Mixed Autism and ADHD

Neuropsychological Characteristics of Children with Mixed Autism and ADHD

Association between autism symptoms and functioning in children with ADHD

The impact of study design and diagnostic approach in a large multi-centre ADHD study: Part 2: Dimensional measures of psychopathology and intelligence

Contact Info

Product

Resources

About