Autism spectrum disorders co-morbidities and treatment approaches

Kong, Xuejun

doi:10.15761/pd.1000173

Cited by 3 publications

(3 citation statements)

References 59 publications

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“…Among children with ASD, the prevalence of intellectual disability (ID) ranges from 30% [ 6 , 7 ] to 70% [ 8 , 9 ]. Approximately 19% of patients with ASD present with epilepsy, and around 60% have EEG epileptiform activity [ 10 ]. As in the case of ID, a higher percentage of epilepsy has been noted among patients with autism (11% to as much as 39%) compared to those with ASD [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…As in the case of ID, a higher percentage of epilepsy has been noted among patients with autism (11% to as much as 39%) compared to those with ASD [ 11 ]. Importantly, about 40% of children with both ASD and ID also have epilepsy [ 10 ]. Such a wide diversity of clinical symptoms and the presence of comorbidities may hinder a diagnosis of ASD.…”

Section: Introductionmentioning

confidence: 99%

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The Use of CGH Arrays for Identifying Copy Number Variations in Children with Autism Spectrum Disorder

Kucińska,

Hawuła,

Rutkowska

et al. 2024

Brain Sciences

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Autism spectrum disorders (ASDs) encompass a broad group of neurodevelopmental disorders with varied clinical symptoms, all being characterized by deficits in social communication and repetitive behavior. Although the etiology of ASD is heterogeneous, with many genes involved, a crucial role is believed to be played by copy number variants (CNVs). The present study examines the role of copy number variation in the development of isolated ASD, or ASD with additional clinical features, among a group of 180 patients ranging in age from two years and four months to 17 years and nine months. Samples were taken and subjected to array-based comparative genomic hybridization (aCGH), the gold standard in detecting gains or losses in the genome, using a 4 × 180 CytoSure Autism Research Array, with a resolution of around 75 kb. The results indicated the presence of nine pathogenic and six likely pathogenic imbalances, and 20 variants of uncertain significance (VUSs) among the group. Relevant variants were more prevalent in patients with ASD and additional clinical features. Twelve of the detected variants, four of which were probably pathogenic, would not have been identified using the routine 8 × 60 k microarray. These results confirm the value of microarrays in ASD diagnostics and highlight the need for dedicated tools.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Use of CGH Arrays for Identifying Copy Number Variations in Children with Autism Spectrum Disorder

Kucińska,

Hawuła,

Rutkowska

et al. 2024

Brain Sciences

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“…The majority of people with autism have one or more comorbid psychiatric illnesses. Sleep disorders, anxiety, epilepsy, depression, and Attention Deficit Hyperactivity Disorder (ADHD) are the most common co-morbid diagnoses, although eating disorders, Obsessive Compulsive Disorder, bipolar disorder, hetero-aggression, and self-harm are also common in autistic patients (Kong, 2018). The socio-economic impact of this disorder in the region of Chattogram and the mental health condition of the subject's parents due to stress, hormonal imbalance, antibiotic treatment, etc.…”

Section: Socio-demographic Study and Clinical Profiling Of Asdmentioning

confidence: 99%

A case-control study along with an epidemiological approach to CNTNAP2 polymorphism among Bangladeshi ASD children

Siddiqua¹,

Akter²,

Mia³

et al. 2022

Asian J. Med. Biol. Res.

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ASD (Autism Spectrum Disorder) is a neuropsychiatric disorder with a hereditary component, and its prevalence in South Asia was assessed 1, out of every 93 children. Moreover, recent studies suggested that the etiology of autism is thought to be linked to anomalies in the synapse, where mutation or deletion of synaptic gene CNTNAP2 is responsible. Therefore, this research was aimed to find out specific signs and symptoms of ASD individuals as well as the distribution pattern of the CNTNAP2 allelic variant (rs7794745) as a genetic risk factor in the Bangladeshi population. A case-control study including an epidemiological survey to investigate the association and pathophysiology of CNTNAP2 (rs7794745) with ASD for the Bangladeshi population has been studied, where PCR-RFLP analysis and Sanger sequencing were used for 180 individuals (90 ASD samples and 90 healthy controls). Our retrieved data speculated a diverse clinical profile of ASD, in comparison to the control group (n=110); where 80.9% (p ≤0.001) of ASD patients (n =100) had severe social interaction difficulties, 50% (p ≤0.001) had language impairments, and 40.9% (p ≤0.001) had behavioral abnormalities. Furthermore, findings from Pearson’s chi-square test (p = 0.001) as well as logistic regression analysis of co-dominant (p = 0.0083), and recessive model (p = 0.0075) confirmed significant association between rs7794745 and in our studied sample. This research demonstrates the genetic variation of CNTNAP2 found in our studied population could open a new clue to identifying a reliable biomarker for early diagnosis of ASD though it is recommended that more study is needed with a larger group population. Asian J. Med. Biol. Res. 2022, 8 (2), 79-93

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A Systematic Network of Autism Primary Care Services (SYNAPSE): A Model of Coproduction for the Management of Autism Spectrum Disorder

Kong

Chien

et al. 2019

J Autism Dev Disord

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Autism spectrum disorders co-morbidities and treatment approaches

Cited by 3 publications

References 59 publications

The Use of CGH Arrays for Identifying Copy Number Variations in Children with Autism Spectrum Disorder

The Use of CGH Arrays for Identifying Copy Number Variations in Children with Autism Spectrum Disorder

A case-control study along with an epidemiological approach to CNTNAP2 polymorphism among Bangladeshi ASD children

A Systematic Network of Autism Primary Care Services (SYNAPSE): A Model of Coproduction for the Management of Autism Spectrum Disorder

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