Autism Spectrum Disorder in a Term Birth Neonatal Intensive Care Unit Population

Winkler-Schwartz, Alexander; Garfinkle, Jarred; Shevell, Michael

doi:10.1016/j.pediatrneurol.2014.07.009

Cited by 9 publications

(14 citation statements)

References 37 publications

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“…The main characteristics of the included studies are presented in Table 1, and the variables adjusted and/or matched in each study are presented in eTable 3 in the Supplement. Of the 61 included studies, 27 studies 20,23,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,83 reported on the association of cesarean delivery with a diagnosis of ASD (59 795 cases), 13 studies 19,24,42,52,55,56,57,58,59,60,61,62,63 with attention-deficit/hyperactivity disorder (ADHD) (92 718 cases), 3 studies 42,64,65 with intellectual disabilities (485 cases), 3 studies 22,66,67 with tic disorders (6181 cases), 4 studies 25,26,68,69 with eating disorders (4550 cases), 3 studies 21,70,71 with obsessive-compulsive disorder (OCD; 7295 cases), 5 studies 72,73,74,75,76 with major depression or affective psychoses (8561 cases), and 7 studies 73,77,78,79,80,81,82 with nonaffective psychoses (7195 cases). Study quality was defined as high for 18 of 22 cohorts (82%) and 20 of 40 c...…”

Section: Resultsmentioning

confidence: 99%

“…For the second aim, 20 studies 20,23,24,34,35,39,41,43,49,53,58,59,60,66,67,73,74,75,81,82 (10 620 715 deliveries) and 18 studies 20,23,24,34,35,39,43,46,49,58,59,60,66,67,73,74,75,81 (10 597 234 deliveries) assessed the risk of ASD, ADHD, tic disorders, and affective and nonaffective psychoses in offspring born via elective and emergency cesarean delivery, each compared with offspring born via unassisted vaginal delivery. Similar to the results of the main analyses, both elective and emergency cesarean deliveries were associated with increased odds of ADHD and ASD; for these analyses, heterogeneity was low ( I 2 range, 10.7%-33.6%) except for ASD when assessing the association with elective cesarean delivery ( I 2 = 87.9%) (eFigure 3 in the Supplement).…”

Section: Resultsmentioning

confidence: 99%

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Association of Cesarean Delivery With Risk of Neurodevelopmental and Psychiatric Disorders in the Offspring

et al. 2019

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Association of Cesarean Delivery With Risk of Neurodevelopmental and Psychiatric Disorders in the Offspring

et al. 2019

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“…Although we found no association between ASD and pre-, peri- and postnatal factors, the risk frequency for ASD in PNBs hospitalized in an NICU is high and an important aspect to investigate [ 24 ]. Winkler-Schwartz and Garfinkle underscore the need for early screening, preferentially in newborns monitored in an NICU [ 25 ], especially when the prevalence of ASD in school-age children differs from that of premature children [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Screening for Autism Spectrum Disorder in Premature Subjects Hospitalized in a Neonatal Intensive Care Unit

Holanda

Costa

Sampaio

et al. 2020

IJERPH

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Considering that the average age for diagnosis of autism spectrum disorder (ASD) is 4–5 years, testing screening methods for ASD risk in early infancy is a public health priority. This study aims to identify the risks for development of ASD in children born prematurely and hospitalized in a neonatal intensive care unit (NICU) and explore the association with pre-, peri- and postnatal factors. Methods: The children’s families were contacted by telephone when their child was between 18 and 24 months of age, to apply the Modified Checklist for Autism in Toddlers (M-CHAT). The sample consisted of 40 children (57.5% boys). M-CHAT screening revealed that 50% of the sample showed early signs of ASD. Although the frequency of delayed development was higher in boys, this difference was not statistically significant between the sexes (p = 0.11). Assessment of the association between perinatal conditions and early signs of autism in children hospitalized in an NICU exhibited no correlation between the factors analyzed (birth weight and type of delivery). The findings indicate a high risk of ASD in premature children, demonstrating no associations with gestational and neonatal variables or the hospitalization conditions of the NICUs investigated.

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“…The study selection process is shown in Figure 1. The studies included five cohort studies 1,[18][19][20][21] and five case-control studies, 4,[14][15][16][17] with a total sample size of 10,637,035 participants.…”

Section: Study Descriptionmentioning

confidence: 99%

“…13) Several studies have been published regarding exposure to meconium and the risk of developing ASD. 1,4,[14][15][16][17][18][19][20][21] However, their results differed; therefore, the present systematic review and metaanalysis pooled all epidemiologic case-control and cohort studies retrieved from broader…”

Section: Introductionmentioning

confidence: 99%

Is meconium exposure associated with autism spectrum disorders in children?

et al. 2021

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The results differ among published studies regarding exposure to meconium and the risk of developing autism spectrum disorders (ASD). The present study pooled all of the epidemiologic studies retrieved from broader databases on the association between meconium exposure and risk of developing ASD in children. The Web of Science, PubMed, Scopus, and Google Scholar databases were searched without language restrictions for articles published between their inception to February 20, 2020, using relevant keywords. The pooled odds ratios (ORs) and their 95% confidence intervals (CIs (were calculated as random-effect estimates of the associations among studies. A subgroup analysis was conducted to explore any potential sources of heterogeneity among studies. The pooled estimate of OR reported a weakly significant association between meconium exposure and ASD development in children (OR, 1.13; 95% CI, 1.03-1.24). There was low heterogeneity among the articles reporting risk for ASD among children (I 2 = 19.3%; P = 0.259). The results of subgroup analysis based on meconium exposure showed a significant association between a meconium-stained neonate and ASD development (OR, 1.18; 95% CI, 1.11-1.24). Meconium exposure was weakly associated with an increased risk of ASD. However, more evidence based on large prospective cohort studies is required to provide conclusive evidence about whether meconium exposure is associated with an increased risk of ASD development.

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Autism Spectrum Disorder in a Term Birth Neonatal Intensive Care Unit Population

Cited by 9 publications

References 37 publications

Association of Cesarean Delivery With Risk of Neurodevelopmental and Psychiatric Disorders in the Offspring

Association of Cesarean Delivery With Risk of Neurodevelopmental and Psychiatric Disorders in the Offspring

Screening for Autism Spectrum Disorder in Premature Subjects Hospitalized in a Neonatal Intensive Care Unit

Is meconium exposure associated with autism spectrum disorders in children?

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