Autism‐relevant social abnormalities in mice exposed perinatally to extremely low frequency electromagnetic fields

Alsaeed, Ibrahim; Al‐Somali, Faisal; Sakhnini, Lama; Aljarallah, Omar S.; Hamdan, Rayan M.M.; Bubishate, Saleh A.; Sarfaraz, Ziyab Khan; Kamal, Amer

doi:10.1016/j.ijdevneu.2014.06.010

Cited by 14 publications

(10 citation statements)

References 56 publications

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“…Besides, studies carried out by Del et al showed that exposure to 80 mT magnetic field for 2 h altered behavioral patterns in OFT (Del Seppia et al, 2003). However, it was reported recently that mice exposed to ELF-EMF (1 mT) for 14 days can still maintain normal anxiety-like behavior (Alsaeed et al, 2014). In addition, Szemerszky et al showed that 4-6 weeks exposure to 500 mT ELF-EMF had no effect on anxiety-like behavior (Szemerszky et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Effects of extremely low frequency electromagnetic fields (100 μT) on behaviors in rats

Lai

Zhang²,

Liu³

et al. 2016

NeuroToxicology

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Recently, extremely low frequency electromagnetic fields (ELF-EMF) have received considerable attentions for their potential pathogenicity. In the present study, we explored the effects of ELF-EMF on behaviors of adult male rats. Sixty adult male rats were randomly divided into two groups, the sham exposure group and the 50Hz/100μT ELF-EMF exposure group. During the 24 weeks exposure, body weight, as well as food and water intake were recorded. Results showed that food and water intake and the body weight of the rats were not affected by the exposure. After 24 weeks exposure, open field test and elevated plus maze were conducted to evaluate the anxiety-like behavior, the tail suspension test and forced swim test were conducted to evaluate depression-like behavior and Morris water maze and fear conditioning tests were used to evaluate the cognitive and memory ability. Exposure to ELF-EMF did not induce any anxiety-like or depression-like behaviors compared with the sham exposure. Moreover, the cognitive and memory ability was not impaired by the ELF-EMF exposure. Furthermore, ELF-EMF exposure did not affect the morphology and histology of the brain. In conclusion, 24 weeks exposure to 50Hz/100μT ELF-EMF had no effect on the behaviors of the adult male rats.

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Section: Discussionmentioning

confidence: 99%

Effects of extremely low frequency electromagnetic fields (100 μT) on behaviors in rats

Lai

Zhang²,

Liu³

et al. 2016

NeuroToxicology

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show abstract

“…In addition, maternal use of valproate to treat epilepsy during pregnancy is associated with significantly increased risk of ASD [ 170 ]. Finally, mice exposed to low frequency electromagnetic fields show a lack of normal sociability and preference for social novelty while maintaining otherwise normal behaviors [ 171 ]. While these studies show associations and links between factors in the environment and ASD, much less is known regarding how exposure to these developmental influences trigger changes to the epigenome.…”

Section: Exposure To Air Pollution Pesticides Prenatal Valproate Cmentioning

confidence: 99%

Merging Data from Genetic and Epigenetic Approaches to Better Understand Autistic Spectrum Disorder

Grayson

Guidotti

2015

Epigenomics

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Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that is characterized by a wide range of cognitive and behavioral abnormalities. Genetic research has identified large numbers of genes that contribute to ASD phenotypes. There is compelling evidence that environmental factors contribute to ASD through influences that differentially impact the brain through epigenetic mechanisms. Both genetic mutations and epigenetic influences alter gene expression in different cell types of the brain. Mutations impact the expression of large numbers of genes and also have downstream consequences depending on specific pathways associated with the mutation. Environmental factors impact the expression of sets of genes by altering methylation/hydroxymethylation patterns, local histone modification patterns and chromatin remodeling. Herein, we discuss recent developments in the research of ASD with a focus on epigenetic pathways as a complement to current genetic screening.

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“…These behavioral disturbances were correlated with high corticosterone secretion [16]. Mice prenatally exposed to ELF-MF (50 Hz, 1 mT) lacked sociability and preference of social novelty, which can be a sign of autism-relevant social abnormalities; however, they did not show anxiety-like behav-ior [134]. The continuous (21 days) exposure to extremely low-frequency magnetic field (50 Hz, 10 mT) had no significant effect on activity and exploration activity but significantly increased stress and anxiety-related behavior in rats [135].…”

Section: Association Between Elf-mf Exposure and Emotional Behavior And Wellbeingmentioning

confidence: 98%

Extremely Low-Frequency Magnetic Field as a Stress Factor—Really Detrimental?—Insight into Literature from the Last Decade

Klimek

Rogalska

2021

Brain Sciences

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Biological effects of extremely low-frequency magnetic field (ELF-MF) and its consequences on human health have become the subject of important and recurrent public debate. ELF-MF evokes cell/organism responses that are characteristic to a general stress reaction, thus it can be regarded as a stress factor. Exposure to ELF-MF “turns on” different intracellular mechanisms into both directions: compensatory or deleterious ones. ELF-MF can provoke morphological and physiological changes in stress-related systems, mainly nervous, hormonal, and immunological ones. This review summarizes the ELF-MF-mediated changes at various levels of the organism organization. Special attention is placed on the review of literature from the last decade. Most studies on ELF-MF effects concentrate on its negative influence, e.g., impairment of behavior towards depressive and anxiety disorders; however, in the last decade there was an increase in the number of research studies showing stimulating impact of ELF-MF on neuroplasticity and neurorehabilitation. In the face of numerous studies on the ELF-MF action, it is necessary to systematize the knowledge for a better understanding of the phenomenon, in order to reduce the risk associated with the exposure to this factor and to recognize the possibility of using it as a therapeutic agent.

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Autism‐relevant social abnormalities in mice exposed perinatally to extremely low frequency electromagnetic fields

Cited by 14 publications

References 56 publications

Effects of extremely low frequency electromagnetic fields (100 μT) on behaviors in rats

Effects of extremely low frequency electromagnetic fields (100 μT) on behaviors in rats

Merging Data from Genetic and Epigenetic Approaches to Better Understand Autistic Spectrum Disorder

Extremely Low-Frequency Magnetic Field as a Stress Factor—Really Detrimental?—Insight into Literature from the Last Decade

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