Autism Occurrence by MMR Vaccine Status Among US Children With Older Siblings With and Without Autism

Jain, Anjali; Marshall, Jaclyn; Buikema, Ami; Bancroft, T. A.; Kelly, Jonathan P.; Newschaffer, Craig J.

doi:10.1097/ogx.0000000000000231

Cited by 36 publications

(45 citation statements)

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“…A 2015 study of autism occurrence by MMR vaccine status among US children with older siblings with and without autism concluded: "In this large sample of privately insured children with older siblings, receipt of the MMR vaccine was not associated with increased risk of autism spectrum disorder (ASD), regardless of whether older siblings had ASD. These findings indicate no harmful association between MMR vaccine receipt and ASD even among children already at higher risk for ASD (Jain et al, 2015)." Conclusions from the two studies referenced above typify the conclusions from other large-scale studies in the open peer-reviewed literature on potential links between the MMR vaccine and autism.…”

Section: ) Studies Showing No Link Between Mmr Vaccine and Autismsupporting

confidence: 55%

Under-reporting of Adverse Events in the Biomedical Literature

Kostoff

2016

Journal of Data and Information Science

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Purpose: To address the under-reporting of research results, with emphasis on the underreporting/distorted reporting of adverse events in the biomedical research literature.Design/methodology/approach: A four-step approach is used: (1) To identify the characteristics of literature that make it adequate to support policy; (2) to show how each of these characteristics becomes degraded to make inadequate literature; (3) to identify incentives to prevent inadequate literature; and (4) to show policy implications of inadequate literature. Findings:This review has provided reasons for, and examples of, adverse health effects of myriad substances (1) being under-reported in the premiere biomedical literature, or (2) entering this literature in distorted form. Since there is no way to gauge the extent of this under/distorted-reporting, the quality and credibility of the 'premiere' biomedical literature is unknown. Therefore, any types of meta-analyses or scientometric analyses of this literature http://ir.las.ac.cn/handle/12502/8905 will have unknown quality and credibility. The most sophisticated scientometric analysis cannot compensate for a highly flawed database. Research limitations:The main limitation is in identifying examples of under-reporting. There are many incentives for under-reporting and few dis-incentives.Practical implications: Almost all research publications, addressing causes of disease, treatments for disease, diagnoses for disease, scientometrics of disease and health issues, and other aspects of healthcare, build upon previous healthcare-related research published. Many researchers will not have laboratories or other capabilities to replicate or validate the published research, and depend almost completely on the integrity of this literature. If the literature is distorted, then future research can be misguided, and health policy recommendations can be ineffective or worse. Originality/value:This review has examined a much wider range of technical and nontechnical causes for under-reporting of adverse events in the biomedical literature than previous studies.

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Section: ) Studies Showing No Link Between Mmr Vaccine and Autismsupporting

confidence: 55%

Under-reporting of Adverse Events in the Biomedical Literature

Kostoff

2016

Journal of Data and Information Science

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“…In all cases it was noted by the Court of Federal Claims, or indicated in settlement agreements, that the children had autism or ASD [39]. On the other hand, numerous epidemiological studies have found no association between receipt of selected vaccines (in particular the combined measles, mumps, and rubella vaccine) and autism [10,[40][41][42][43][44][45], and there is no accepted mechanism by which vaccines could induce autism [46].…”

Section: Introductionmentioning

confidence: 99%

Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12- year old U.S. children

Mawson¹,

Ray²,

Bhuiyan³

et al. 2017

J Transl Sci

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Vaccinations have prevented millions of infectious illnesses, hospitalizations and deaths among U.S. children, yet the long-term health outcomes of the vaccination schedule remain uncertain. Studies have been recommended by the U.S. Institute of Medicine to address this question. This study aimed 1) to compare vaccinated and unvaccinated children on a broad range of health outcomes, and 2) to determine whether an association found between vaccination and neurodevelopmental disorders (NDD), if any, remained significant after adjustment for other measured factors. A cross-sectional study of mothers of children educated at home was carried out in collaboration with homeschool organizations in four U.S. states: Florida, Louisiana, Mississippi and Oregon. Mothers were asked to complete an anonymous online questionnaire on their 6-to 12-year-old biological children with respect to pregnancy-related factors, birth history, vaccinations, physician-diagnosed illnesses, medications used, and health services. NDD, a derived diagnostic measure, was defined as having one or more of the following three closely-related diagnoses: a learning disability, Attention Deficient Hyperactivity Disorder, and Autism Spectrum Disorder. A convenience sample of 666 children was obtained, of which 261 (39%) were unvaccinated. The vaccinated were less likely than the unvaccinated to have been diagnosed with chickenpox and pertussis, but more likely to have been diagnosed with pneumonia, otitis media, allergies and NDD. After adjustment, vaccination, male gender, and preterm birth remained significantly associated with NDD. However, in a final adjusted model with interaction, vaccination but not preterm birth remained associated with NDD, while the interaction of preterm birth and vaccination was associated with a 6.6-fold increased odds of NDD (95% CI: 2.8, 15.5). In conclusion, vaccinated homeschool children were found to have a higher rate of allergies and NDD than unvaccinated homeschool children. While vaccination remained significantly associated with NDD after controlling for other factors, preterm birth coupled with vaccination was associated with an apparent synergistic increase in the odds of NDD. Further research involving larger, independent samples and stronger research designs is needed to verify and understand these unexpected findings in order to optimize the impact of vaccines on children's health.

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“…4,5 Investigators in several subsequent studies have not been able to show any association between the MMR vaccine and autism. 6,7 However, despite scientific evidence to the contrary, vaccine hesitancy persists. There are excellent reviews in which the authors discuss reasons for this worrisome trend.…”

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confidence: 97%

Vaccine hesitancy and unfalsifiability

Glick¹

2015

The Journal of the American Dental Association

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Autism Occurrence by MMR Vaccine Status Among US Children With Older Siblings With and Without Autism

Cited by 36 publications

References 0 publications

Under-reporting of Adverse Events in the Biomedical Literature

Under-reporting of Adverse Events in the Biomedical Literature

Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12- year old U.S. children

Vaccine hesitancy and unfalsifiability

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