Autism and anorexia nervosa: longitudinal prediction of eating disorder outcomes

Leppänen, Jenni; Sedgewick, Felicity; Halls, Daniel; Tchanturia, Kate

doi:10.31234/osf.io/rvxdk

Cited by 1 publication

(1 citation statement)

References 40 publications

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“…Eating disorders (ED) occur at higher rates in the autistic community and in those with greater autistic traits [1][2][3][4][5]. Moreover, such individuals often present with more complex, protracted symptoms and respond less favourably to some standard psychological interventions [6][7][8]. Efforts to understand the factors that predispose, precipitate and perpetuate ED in relation to autism are crucial in developing more effective and individualised clinical interventions and ultimately aiding treatment outcomes for this subgroup.…”

Section: Introductionmentioning

confidence: 99%

Sex-specific mechanisms for eating disorder risk in men and women with autistic traits: the role of alexithymia

et al. 2023

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Background A poorly understood relationship exists between eating disorders (ED) and autism spectrum conditions (ASC: henceforth ‘autism’). ED are more prevalent in autistic people and people with high autistic traits, and autistic features are prognostic of longer illness. Aiming to understand what increases the risk of ED in relation to autism and autistic traits, previous research has implicated alexithymia as a causal mechanism in this relationship. These studies could not, however, disentangle whether alexithymia explains the relationship between ED pathology and autistic traits directly or through its impact on anxious/depressive symptoms, which in turn result in higher ED symptomatology. Moreover, despite evidence for sex differences in the aetiology of ED, little research has examined the impact of sex on these relationships. Methods Focusing on the association between autistic traits and ED psychopathology, we examined independent mediating effects of alexithymia and anxious/depressive symptoms, as well as sequential mediation effects where alexithymia affects ED psychopathology via its impact on anxious/depressive symptoms. Participants were 198 men and 265 women with formally diagnosed and suspected ED, who completed an online survey of standardised scales. Results In men, higher autistic traits were associated with ED psychopathology sequentially via greater alexithymia and through that, greater depressive/anxious symptoms. In women, alexithymia mediated the relationship between autistic traits and ED psychopathology both directly and sequentially through its impact on anxious/depressive symptoms. Interestingly, depressive/anxious symptoms also mediated that relationship independently from alexithymia. Conclusions While cross-sectional, these findings suggest that the relationship between autistic traits and ED symptomatology is mediated by other variables. In support of its proposed role in the aetiology of ED, alexithymia was directly associated with ED symptoms in women. It also affected ED symptoms indirectly, in all participants, via its effect on depressive/anxious symptoms. Interventions focusing on alexithymia may facilitate recovery not only via their effect on ED, but via their effect on other forms of state psychopathology which contribute to the maintenance and development of ED. Sex differences, however, reflect that alternative therapeutic targets for men and women may be beneficial.

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