Authors' response

Browning, Andrew C.; Stewart, Elizabeth A.; Amoaku, Winfried

doi:10.1136/bjophthalmol-2012-301800

Cited by 2 publications

(3 citation statements)

References 14 publications

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“…Surface functionalization of MNPs is a key aspect in creating magnetic scaffolds, because without the surface functionalization, the MNPs would induce genotoxic behavior in tissues and cause necrosis of cells when it is in contact (Figure ) . Fatty acids such as oleic acid have been used to coat the surface of MNPs to render the ferrofluid into a stable, biocompatible, and colloidal solution …”

Section: Resultsmentioning

confidence: 99%

Bacterial Nanocellulose Magnetically Functionalized for Neuro‐Endovascular Treatment

Echeverry‐Rendón

Reece

Pastrana

et al. 2017

Macromolecular Bioscience

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Current treatments for brain aneurysms are invasive, traumatic, and not suitable in most patients with increased risks. A new alternative method is using scaffold stents to create a local and focal attraction force of cells for an in situ reconstruction of the tunica media. For this purpose, a nanostructured bioactive coating is designed to render an asymmetric region of the stent scaffold magnetic and biomimetic, which utilizes bacterial nanocellulose (BNC) as a platform for both magnetic and cell attraction as well as proliferation. The magnetization of the BNC is realized through the reaction of Fe III and II, precipitating superparamagnetic iron oxide nanoparticles (SPION). Subsequently, magnetic bacterial nanocellulose (MBNC) is coated with polyethylene glycol to improve its biocompatibility. Cytotoxicity and biocompatibility are evaluated using porcine aortic smooth muscle cells. Preliminary cellular migration assays demonstrate the behavior between MBNC and cells labeled with SPION. In this work, (1) synthesis of BNC impregnated with magnetic nanoparticles is successfully demonstrated; (2) a viable, resilient, and biocompatible hydrogel membrane is tested for neuroendovascular application using a stent scaffold; (3) cell viability and minimal cytotoxicity is achieved; (4) cell migration tests and examination of cellular magnetic attraction confirm the viability of MBNC as a multifunctional coating.

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Section: Resultsmentioning

confidence: 99%

Bacterial Nanocellulose Magnetically Functionalized for Neuro‐Endovascular Treatment

Echeverry‐Rendón

Reece

Pastrana

et al. 2017

Macromolecular Bioscience

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show abstract

“…Surface functionalization of MNPs is a key aspect in developing magnetic scaffolds, because without it the MNPs would induce genotoxic behavior in tissues and cause necrosis of the cells with which it comes into contact . Fatty acids like oleic acid have been used to coat the surface of MNPs to render the ferrofluid into a stable, biocompatible, colloidal solution . The size distribution of colloidal nanoparticles was analyzed through dynamic light scattering and we found that the mean size of clusters of MNPs is ≈100 nm.…”

Section: Resultsmentioning

confidence: 99%

“…[21] Fatty acids like oleic acid have been used to coat the surface of MNPs to render the ferrofluid into a stable, biocompatible, colloidal solution. [22] The size distribution of colloidal nanoparticles was analyzed through dynamic light scattering and we found that the mean size of clusters of MNPs is ≈100 nm. The BNC scaffold is immersed into the ferrofluid under vigorous stirring (1500 rpm) to promote amalgamation of ferrous ions on the surface of BNC fibers and later NH 4 OH is added in order to produce the ferrous salts Macromol.…”

Section: Meso-scale and Nanoscale-structural Features Of Mnps Bnc Amentioning

confidence: 99%

In situ Study Unravels Bio‐Nanomechanical Behavior in a Magnetic Bacterial Nano‐cellulose (MBNC) Hydrogel for Neuro‐Endovascular Reconstruction

Pavón

Allain

Verma

et al. 2018

Macromolecular Bioscience

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Surgical clipping and endovascular coiling are well recognized as conventional treatments of Penetrating Brain Injury aneurysms. These clinical approaches show partial success, but often result in thrombus formation and the rupture of aneurysm near arterial walls. The authors address these challenging brain traumas with a unique combination of a highly biocompatible biopolymer hydrogel rendered magnetic in a flexible and resilient membrane coating integrated to a scaffold stent platform at the aneurysm neck orifice, which enhances the revascularization modality. This work focuses on the in situ diagnosis of nano‐mechanical behavior of bacterial nanocellulose (BNC) membranes in an aqueous environment used as tissue reconstruction substrates for cerebral aneurysmal neck defects. Nano‐mechanical evaluation, performed using instrumented nano‐indentation, shows with very low normal loads between 0.01 to 0.5 mN, in the presence of deionized water. Mechanical testing and characterization reveals that the nano‐scale response of BNC behaves similar to blood vessel walls with a very low Young´s modulus, E (0.0025 to 0.04 GPa), and an evident creep effect (26.01 ± 3.85 nm s−1). These results confirm a novel multi‐functional membrane using BNC and rendered magnetic with local adhesion of iron‐oxide magnetic nanoparticles.

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Authors' response

Cited by 2 publications

References 14 publications

Bacterial Nanocellulose Magnetically Functionalized for Neuro‐Endovascular Treatment

Bacterial Nanocellulose Magnetically Functionalized for Neuro‐Endovascular Treatment

In situ Study Unravels Bio‐Nanomechanical Behavior in a Magnetic Bacterial Nano‐cellulose (MBNC) Hydrogel for Neuro‐Endovascular Reconstruction

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