Authors' reply to Chadha et al., Sambath et al., and Sharma et al.

Pandey, Avinash; Dutt, Sarjana; Singh, Anjana; Kumar, Amit; Singh, Siddharth

doi:10.4103/crst.crst_25_20

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…Comments: SB290157 has also been reported to have agonist properties at the C3a receptor [1503,1670]. The chemoattractant receptor C5a 2 (also known as GPR77, C5L2) binds C5a and has putative roles in either opposing or promoting inflammatory responses [334,764,785,1504,1981]. Binding to this site may be displaced with the rank order C5a des-Arg (C5) > C5a (C5, P01031) [334,1947] while there is controversy over the ability of C3a (C3, P01024) and C3a des Arg (C3, P01024) to compete [1047,1201,1202,1947].…”

Section: Endogenous Agonistsmentioning

confidence: 99%

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

Alexander,

Christopoulos,

Davenport

et al. 2023

British J Pharmacology

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The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177. G protein‐coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

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Section: Endogenous Agonistsmentioning

confidence: 99%

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

Alexander,

Christopoulos,

Davenport

et al. 2023

British J Pharmacology

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“…Less than half (45.00%) of the farmers perceived effectiveness in the service of organization of capacity programs to farmers in recent advances in agriculture by scientists as good followed by fair (32.50%) and poor (22.50%). Nearly two third (65.84%) of the farmers perceived effectiveness in service of maintenance of smart TV at RBK for interaction with scientists and other experts as poor followed by fair (18.33%) and good (15.83%) [9][10][11].…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of Rythu Bharosa Kendras (RBKs) Services as Perceived by Farmers in the East Godavari District of Andhra Pradesh, India

Saifuddin

Devy

Rao

et al. 2023

AJAEES

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Rythu Bharosa Kendram is One Stop Shop for supplying Government Certified Agri Inputs (Seeds, Fertilizers & Pesticides), Animal Husbandry & Fisheries Inputs to the farmers and has an attached workshop / Knowledge Center for giving scientific Agri Advisories to the farmers. It is integrated with a Call. The study investigated the effectiveness of services of RBK perceived by farmers in the East Godavari district of Andhra Pradesh during 2021-2022. A total sample of 120 farmers was randomly selected from twelve villages viz. Kadiyam, Vemagiri, Muramanda, Kalavacherla, Rajanagram, Velugubanda, Geddanapalli, Bhupalapatnam, S. thimmapuram, Bhatnavalli, Rollapalem and Nadipudi of East Godavari district of Andhra Pradesh. The data were collected with structured interview schedule. The perceived effectiveness of the services of RBKs was studied. It was observed that half (50.83%) of the farmers perceived that services rendered by RBKs were moderately effective followed by highly effective (34.17%) and less effective (15.00%) categories. It can be recommended to the government and policy makers for improvement, restructuring, reforming and modifying the services from RBKs to enhance its effectiveness further.

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“…As a result, they can be employed for the management of various health conditions, mainly heart failure, hypertension, and ascites. (23) The parameters evaluated in this study to examine the diuretic action of the leaf of R. nepalensis in mice were urine volume, urine electrolyte, and urinary pH.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Diuretic Activities of 80% Methanol Leaf Extract and Solvent Fractions ofRumex nepalensisin Mice

Tafesse,

Asrie,

Belete

2023

Preprint

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BackgroundThe leaf ofRumex nepalensishas historically been employed to treat urinary retention and as a diuretic. Despite these assertions, there has been very little research addressing the diuretic effect of the leaves ofR. nepalensis. Therefore, this study was done to examine the diuretic properties of R. nepalensis leaves.MethodsCold maceration with 80% methanol was used to extract the coarsely powdered leaves ofR. nepalensis. The extract was separated using increasing polarity solvents, beginning with n-hexane, ethyl acetate, and water. Mice were split into sections to test the plant’s diuretic properties. The negative control groups were given either distilled water or 2% tween 80; the positive control groups were given furosemide (10 mg/kg); and the test groups were given the 80% methanol extract and solvent fractions orally at dosages of 100, 200, and 400 mg/kg. The urine volume was determined, and urine analysis was performed on each extract.ResultsAt dosage levels of 200 mg/kg and 400 mg/kg, the 80% methanol extract, ethyl acetate fraction, and aqueous fraction all produced substantial diuresis (p<0.001) as compared to the negative control. Similarly, mice given the 80% methanol extract, ethyl acetate fraction, and aqueous fraction demonstrated substantial natriuresis (p<0.001) and kaliuresis (p<0.001) at dosages of 200 mg/kg and 400 mg/kg, respectively, in comparison to the negative control.ConclusionThe diuretic activity ofR. nepalensiswas significantly seen in the 80% methanol extract, ethyl acetate, and aqueous fractions, which corroborated the plant’s traditional use.

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Authors' reply to Chadha et al., Sambath et al., and Sharma et al.

Cited by 4 publications

References 8 publications

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

Effectiveness of Rythu Bharosa Kendras (RBKs) Services as Perceived by Farmers in the East Godavari District of Andhra Pradesh, India

Evaluation of the Diuretic Activities of 80% Methanol Leaf Extract and Solvent Fractions ofRumex nepalensisin Mice

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