Authors’ correction for Euro Surveill. 2017;22(11)

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doi:10.2807/1560-7917.es.2017.22.19.30531

Cited by 1 publication

(6 citation statements)

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“…RNA-positivity also had an inverse association with age in dromedaries across Morocco, Burkina Faso and Ethiopia (23). Two studies in Egypt measured similar positivity rates between juveniles and adults (29, 30).…”

Section: Resultsmentioning

confidence: 77%

“…Higher prevalence of RNA shedding was found in imported animals by three studies in Egypt, however site-type is a potential confounder, with local camels being sampled from farms and villages, whilst imported animals were sampled in markets, quarantine centres and abattoirs (27, 29, 30). A study in KSA sampled both local and imported dromedaries within live animal markets found that locally-reared animals had significantly higher prevalence of viral shedding (51).…”

Section: Resultsmentioning

confidence: 96%

“…Samples taken from the large feral camel population in Australia were seronegative, along with dromedaries in Kazakhstan and in zoos in Japan, and Northern America (17, 20, 21, 24, 37, 61). No other species tested alongside dromedaries had neutralising antibodies except a small number of alpacas and llamas living in close quarters with dromedaries in Israel (35), and 1 sheep in Egypt (30).…”

Section: Resultsmentioning

confidence: 99%

“…Several studies found imported animals to have significantly higher seroprevalence than their locally bred counterparts (22, 25, 29, 30). Dromedaries sampled at markets, abattoirs and quarantine sites had higher seroprevalence than those in farms, villages and research facilities (22, 29, 30, 39). In some cases, dromedary origin varied with the type of site sampled suggesting confounding.…”

Section: Resultsmentioning

confidence: 99%

“…Our search found that dromedary populations in 16 countries have been tested for MERS-CoV RNA, 13 of which report positive results indicating active infection. These include KSA (0.12-56%) (45, 46, 49-51, 70), UAE (0-29% (62–66) or 0-100% if dromedaries epidemiologically linked to human MERS-CoV cases are included(67–69)), Qatar (22-79%) (15, 58, 71, 72), Oman (7%) (55), Iraq (15%) (34), and Jordan (62%) (39), as well as Egypt (4-15%) (27, 29, 30), Ethiopia (10%) (23), Kenya (0.35-0.95%) (43, 44), Nigeria (3-11%) (53, 54), Burkina Faso (5%) (23), Morocco (2%) (23), and Pakistan (3%) (57). See Fig 4 for a map of RNA prevalence, and Table 1).…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

A systematic review of MERS-CoV (Middle East Respiratory Syndrome Coronavirus) seroprevalence and viral RNA prevalence in dromedary camels: implications for animal vaccination

Dighe

Jombart

Kerkhove

et al. 2019

Preprint

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27Human infection with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is driven by 28 recurring dromedary-to-human spill-over events, leading decision-makers to consider dromedary 29 vaccination. Dromedary vaccine candidates in the development pipeline are showing hopeful results, 30 but gaps in our understanding of the epidemiology of MERS-CoV in dromedaries must be addressed 31 to design and evaluate potential vaccination strategies. We systematically reviewed the published 32 literature reporting seroprevalence and/or prevalence of active MERS-CoV infection in dromedary 33 populations from both cross-sectional and longitudinal studies, including 60 studies in our qualitative 34 syntheses. MERS-CoV seroprevalence increased with age up to 80-100% in adult dromedaries 35 supporting geographically wide spread endemicity of MERS-CoV in dromedaries in both the Arabian 36 Peninsula and countries exporting dromedaries from Africa. The high prevalence of active infection 37 measured in juveniles and at sites where dromedary populations mix should guide further 38 investigation -particularly of dromedary movement -and inform vaccination strategy design. 39 40 41 42 43 44 45 46 47 48 49 50 . CC-BY 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/574103 doi: bioRxiv preprint 65 studies (7). 66 However, vaccine strategy evaluation is currently precluded by gaps in the understanding of the 67 epidemiology of MERS-CoV in dromedaries. The dromedary population is highly heterogeneous and 68 spans a wide geographic area stretching from West Africa through to the Middle East and parts of 69 Asia. Knowing when and where dromedaries would need to be targeted, and the likely impact of 70 vaccination, is necessary before further consideration of dromedary vaccination in the wider 71 socioeconomic and cultural context. 72 Here, we systematically reviewed published studies that measured MERS-CoV antibody 73 seroprevalence in dromedaries and/or prevalence of viral RNA in dromedaries. Assuming assay 74 specificity and long-term presence of antibodies after infection, seroprevalence can be used to 75 estimate what proportion of a dromedary population has ever been infected with MERS-CoV. Broken 76 down by age class, this can tell us when most animals encounter the infection for the first time. 77 Additionally, although whole-virus isolation and culture is necessary to confirm whether the shedding . CC-BY 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/574103 doi: bioRxiv preprint 101 When available, we took the results of neutralisation-based testing over methods that determined 102 seropositivity based on antibody screening tests alone. Neutralising antibody tests are more specific 103 and are the WHO (World Health Organisation) recommended method for confirming MERS-CoV 104 seropositi...

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Section: Resultsmentioning

confidence: 77%