Authorised medicinal product Aspecton® Oral Drops containing thyme extract KMTv24497 shows antiviral activity against viruses which cause respiratory infections

Lenz, Eva; Müller, Christin; Mostafa, Ahmed; Dzieciolowski, Julia; Kanrai, Pumaree; Dam, Sharmistha; Cwientzek, Ute; Prenner, Lars-Norbert; Pleschka, Stephan

doi:10.1016/j.hermed.2018.02.003

Cited by 11 publications

(7 citation statements)

References 20 publications

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“…These results corroborate those of SardariS et al [11]. It was also noted that Thymus vulgaris induces an increase in lymphocytes which provide a better defence against the coronavirus (Schonknecht Karina et al and SardariS et al) [11,12]. However, in our subjects, the clinical improvement occured earlier as the evaluation was done at Day 4 against Day 5 on average, post-initiation of the treatment (Schonknecht Karina et al and SardariS et al) [11,12].…”

Section: Discussionsupporting

confidence: 89%

“…It was also noted that Thymus vulgaris induces an increase in lymphocytes which provide a better defence against the coronavirus (Schonknecht Karina et al and SardariS et al) [11,12]. However, in our subjects, the clinical improvement occured earlier as the evaluation was done at Day 4 against Day 5 on average, post-initiation of the treatment (Schonknecht Karina et al and SardariS et al) [11,12]. This would be justified by the use by our patients of concentrated dry powder extract containing several active components which supposedly acted better than the isolated essential oil extract of Thymus vulgaris.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy and Tolerance of Thymus Vulgaris Extract in Patients with Covid-19

E¹

2021

J PhyMed Rehab Stud Rep

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The coronavirus disease 19 (COVID-19) has been a pandemic since February 2020. So far, no effective treatment has been found. WHO has recommended research on medicinal plants as an alternative treatment course. Several studies conducted on Thymus vulgaris have established its antioxidant, antiviral and immunomodulatory properties that induce the elimination of viruses such as Herpes simplex Virus 1 and 2. Following this, we initiated a study entitled Efficacy and tolerance of Thymus vulgaris extract in patients with coronavirus 2019. Material and method: Thymus vulgaris powder was used in this study. A consent letter and a questionnaire about the patients’ symptoms were prepared to be used by a research investigator. According to the statistical calculations of this cohort study, 161 patients testing positive for COVID-19 PCR were consecutively recruited, of which 75 patients were not exposed to Thymus vulgaris and 86 patients were exposed. Information from the questionnaire was gathered from the patients before the initiation of conventional treatment (vitamin C 1000 1 tablet/day, Zinc 20 mg 1tablet/day, Azithromycin 500 1cp day and amoxicillin/clavulamic acid 1g/125 1 tablet per 12 hours for six days in both cohorts) and by combining Thymus vulgaris (1 teaspoon, i.e. 5g, in 100 ml of hot water to be taken every 8 hours) by the patients in the exposed cohort. After three days of this treatment, the evaluative part of the questionnaire was completed to assess the impact of taking or not taking Thymus vulgaris on early symptoms and tolerance; on the 10th day after the start of treatment, the PCR control test was carried out. Thereafter, the various statistical analyses were performed. Results: Statistical evaluation after three days of treatment shows that taking Thymus vulgaris has a statistically significant positive effect on cough (p <0.01), dyspnoea (p <0.001), dizziness (p <0.029), fatigue (p <0.001), anorexia (p <0.001), chest pain (p <0.001), fever (p <0.024), agueusia (p <0.029) and anosmia (p <0.001). There was a significant decrease in neutrophils (p <0.01); in addition, the lymphocyte count increased significantly (p <0.001) as did the serum calcium level (p <0.03). Blood urea level decreased significantly (p <0.01). Significant negative results of the COVID-19 PCR were obtained at Day 10 in the exposed group (p <0.001). In addition, there was no significant change in other biological parameters such as creatinine, blood glucose, aspartate amino transferase. Conclusion: Results of this study show that the use of the powder of Thymus vulgaris, a medicinal plant, with antioxidant, immunomodulatory and antiviral properties, was very effective on coronavirus-induced symptoms and virus elimination. Moreover, there was good tolerance after taking Thymus vulgaris.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Efficacy and Tolerance of Thymus Vulgaris Extract in Patients with Covid-19

E¹

2021

J PhyMed Rehab Stud Rep

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“…Folk medicine and natural plant extracts play a key role in treating many life-threatening diseases such as influenza . Therefore, we aimed in this study to analyze the antiviral activity of a panel of natural plant extracts against two different influenza A virus subtypes (A/H1N1 and A/H5N1).…”

Section: Discussionmentioning

confidence: 99%

“…Folk medicine and natural plant extracts play a key role in treating many life-threatening diseases such as influenza. 32 Therefore, we aimed in this study to analyze the antiviral activity of a panel of natural plant extracts against two different influenza A virus subtypes (A/H1N1 and A/H5N1). Interestingly, out of the assayed 17 plant extracts, santonica ( A. cina ) flower extract showed potential anti-influenza activity against both IAV subtypes (influenza A/H5N1 and H1N1).…”

Section: Discussionmentioning

confidence: 99%

Robust Antiviral Activity of Santonica Flower Extract (Artemisia cina) against Avian and Human Influenza A Viruses: In Vitro and Chemoinformatic Studies

et al. 2022

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The evolution of drug-resistant viral strains following natural acquisition of resistance mutations is a major obstacle to antiviral therapy. Besides the improper prescription of the currently licensed anti-influenza medications, M2-blockers and neuraminidase inhibitors, to control poultry outbreaks/infections potentiates the emergence of drug-resistant influenza variants. Therefore, there is always a necessity to find out new alternatives with potent activity and high safety. Plant extracts and plant-based chemicals represent a historical antiviral resource with remarkable safety in vitro and in vivo to control the emerging and remerging health threats caused by viral infections. Herein, a panel of purified plant extracts and subsequent plant-derived chemicals were evaluated for their anti-avian influenza activity against zoonotic highly pathogenic influenza A/H5N1 virus. Interestingly, santonica flower extract (Artemisia cina) showed the most promising anti-H5N1 activity with a highly safe half-maximal cytotoxic concentration 50 (CC50 > 10 mg/mL) and inhibitory concentration 50 (IC50 of 3.42 μg/mL). To confirm the anti-influenza activity, we assessed the anti-influenza activity of the selected plant extracts against seasonal human influenza A/H1N1 virus and we found that santonica flower extract showed a robust anti-influenza activity that was comparable to the activity against influenza A/H5N1. Furthermore, the mode of action for santonica flower extract with strong inhibitory activity on the abovementioned influenza strains was elucidated, showing a virucidal effect. To go deeper about the activity of the chemometric component of the extract, the major constituent, santonin, was further selected for in vitro screening against influenza A/H5N1 (IC50 = 1.701 μg/mL) and influenza A/H1N1 (IC50 = 2.91 μg/mL). The oxygen of carbonyl functionality in the cyclohexene ring succeeded to form a hydrogen bond with the neuraminidase active site. Despite the fact that santonin revealed similarity to both reference neuraminidase inhibitors in forming hydrogen bonds with essential amino acids, it illustrated shape alignment to oseltamivir more than zanamivir according to Tanimoto algorithms. This study highlights the applicability of santonica flower extract as a promising natural antiviral against low and highly pathogenic influenza A viruses.

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“…Lenz et al [ 120 ] also showed antiviral activity of thyme extract (in a commercial preparation, where the active compound is thymol according to the authors) against the human rhinovirus 1a (HRV1a, MDCK/A549 cells, MOI 1).…”

Section: Most Commonly Used Medicinal Plants For the Treatment Of The...mentioning

confidence: 99%

Natural Products for the Prevention and Treatment of Common Cold and Viral Respiratory Infections

et al. 2023

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The common cold is generally considered a usually harmless infectious disease of the upper respiratory pathway, with mostly mild symptoms. However, it should not be overlooked, as a severe cold can lead to serious complications, resulting in hospitalization or death in vulnerable patients. The treatment of the common cold remains purely symptomatic. Analgesics as well as oral antihistamines or decongestants may be advised to relieve fever, and local treatments can clear the airways and relieve nasal congestion, rhinorrhea, or sneezing. Certain medicinal plant specialties can be used as therapy or as complementary self-treatment. Recent scientific advances discussed in more detail in this review have demonstrated the plant’s efficiency in the treatment of the common cold. This review presents an overview of plants used worldwide in the treatment of cold diseases.

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Authorised medicinal product Aspecton® Oral Drops containing thyme extract KMTv24497 shows antiviral activity against viruses which cause respiratory infections

Cited by 11 publications

References 20 publications

Efficacy and Tolerance of Thymus Vulgaris Extract in Patients with Covid-19

Efficacy and Tolerance of Thymus Vulgaris Extract in Patients with Covid-19

Robust Antiviral Activity of Santonica Flower Extract (Artemisia cina) against Avian and Human Influenza A Viruses: In Vitro and Chemoinformatic Studies

Natural Products for the Prevention and Treatment of Common Cold and Viral Respiratory Infections

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