Author response: Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

Highlights • A novel Vcan mouse allele, Vcan AA , has ADAMTS protease-resistant versican. • Vcan AA/AA mice are viable and develop soft tissue-syndactyly (STS) • Vcan AA/AA STS is rendered more severe in combination with Adamts20 Bt/Bt . • Mice lacking the versican GAGβ domain, but not the GAGα domain, also have STS. • The versican GAGβ proteolytic fragment versikine is necessary for web regression.

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A new mouse mutant with cleavage-resistant versican and isoform-specific versican mutants demonstrate that proteolysis at the Glu441-Ala442 peptide bond in the V1 isoform is essential for interdigital web regression

Nandadasa

Koch

Tran‐Lundmark

et al. 2021

Matrix Biology Plus

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Author response: Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

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A new mouse mutant with cleavage-resistant versican and isoform-specific versican mutants demonstrate that proteolysis at the Glu441-Ala442 peptide bond in the V1 isoform is essential for interdigital web regression

A new mouse mutant with cleavage-resistant versican and isoform-specific versican mutants demonstrate that proteolysis at the Glu441-Ala442 peptide bond in the V1 isoform is essential for interdigital web regression

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