Author response: Structural insights into SETD3-mediated histidine methylation on β-actin

Guo, Qiong; Liao, Shanhui; Kwiatkowski, Sebastian; Tomaka, Weronika; Yu, Huijuan; Wu, Gao; Tu, Xiaoming; Min, Jinrong; Drożak, Jakub; Xu, Chao

doi:10.7554/elife.43676.031

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“…The best-known methyl mark on actin is histidine 73 methylation (actin-H73me), with methylation at this site promoting actin polymerization. Recently, the methyltransferase responsible for this mark was identified as SETD3 (Dai et al, 2019;Guo et al, 2019;Kwiatkowski et al, 2018;Wilkinson et al, 2019). However, whether SETD3 acts as a writer on chromatin is controversial (Eom et al, 2011;Wilkinson et al, 2019).…”

Section: Methylation Of the Cytoskeleton: Chromatocytoskeletal Activity Of The Epigenetic Machinerymentioning

confidence: 99%

Remodeling the epigenome and (epi)cytoskeleton: a new paradigm for co-regulation by methylation

Walker

Burggren

2020

Journal of Experimental Biology

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The epigenome determines heritable patterns of gene expression in the absence of changes in DNA sequence. The result is programming of different cellular-, tissue- and organ-specific phenotypes from a single organismic genome. Epigenetic marks that comprise the epigenome (e.g. methylation) are placed upon or removed from chromatin (histones and DNA) to direct the activity of effectors that regulate gene expression and chromatin structure. Recently, the cytoskeleton has been identified as a second target for the cell's epigenetic machinery. Several epigenetic ‘readers, writers and erasers’ that remodel chromatin have been discovered to also remodel the cytoskeleton, regulating structure and function of microtubules and actin filaments. This points to an emerging paradigm for dual-function remodelers with ‘chromatocytoskeletal’ activity that can integrate cytoplasmic and nuclear functions. For example, the SET domain-containing 2 methyltransferase (SETD2) has chromatocytoskeletal activity, methylating both histones and microtubules. The SETD2 methyl mark on chromatin is required for efficient DNA repair, and its microtubule methyl mark is required for proper chromosome segregation during mitosis. This unexpected convergence of SETD2 activity on histones and microtubules to maintain genomic stability suggests the intriguing possibility of an expanded role in the cell for chromatocytoskeletal proteins that read, write and erase methyl marks on the cytoskeleton as well as chromatin. Coordinated use of methyl marks to remodel both the epigenome and the (epi)cytoskeleton opens the possibility for integrated regulation (which we refer to as ‘epiregulation’) of other higher-level functions, such as muscle contraction or learning and memory, and could even have evolutionary implications.

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Section: Methylation Of the Cytoskeleton: Chromatocytoskeletal Activity Of The Epigenetic Machinerymentioning

confidence: 99%

Remodeling the epigenome and (epi)cytoskeleton: a new paradigm for co-regulation by methylation

Walker

Burggren

2020

Journal of Experimental Biology

View full text Add to dashboard Cite

show abstract

Author response: Structural insights into SETD3-mediated histidine methylation on β-actin

Cited by 1 publication

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Remodeling the epigenome and (epi)cytoskeleton: a new paradigm for co-regulation by methylation

Remodeling the epigenome and (epi)cytoskeleton: a new paradigm for co-regulation by methylation

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