Author response: Proximity labeling identifies LOTUS domain proteins that promote the formation of perinuclear germ granules in C. elegans

Price, Ian F.; Hertz, Hannah L.; Pastore, Benjamin; Wagner, Jillian; Tang, Wen

doi:10.7554/elife.72276.sa2

2021

DOI: 10.7554/elife.72276.sa2

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Author response: Proximity labeling identifies LOTUS domain proteins that promote the formation of perinuclear germ granules in C. elegans

Ian F. Price¹,

Hannah L. Hertz²,

Benjamin Pastore³

et al.

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Germ granules and gene regulation in the Caenorhabditis elegans germline

Phillips

Updike

2022

Genetics

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The transparency of Caenorhabditis elegans provides a unique window to observe and study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) assemblies specific to the germline cytoplasm, and they are largely conserved across Metazoa. Within the germline cytoplasm, they are positioned to regulate mRNA abundance, translation, small RNA production, and cytoplasmic inheritance to help specify and maintain germline identity across generations. Here we provide an overview of germ granules and focus on the significance of more recent observations that describe how they further demix into sub-granules, each with unique compositions and functions.

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Germ granules and gene regulation in the Caenorhabditis elegans germline

Phillips

Updike

2022

Genetics

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Author response: Proximity labeling identifies LOTUS domain proteins that promote the formation of perinuclear germ granules in C. elegans

Cited by 1 publication

References 0 publications

Germ granules and gene regulation in the Caenorhabditis elegans germline

Germ granules and gene regulation in the Caenorhabditis elegans germline

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