Author response: POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels

Caron, Alexandre; Lemko, Heather M. Dungan; Castorena, Carlos M.; Fujikawa, Teppei; Lee, Syann; Lord, Caleb C.; Ahmed, Newaz; Lee, Charlotte E.; Holland, William L.; Liu, Chen; Elmquist, Joel K.

doi:10.7554/elife.33710.014

Cited by 2 publications

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“…Thus, in a situation of negative energy balance, such as the malnutrition observed in ALS, the expression of NPY and AgRP is normally increased and POMC expression decreased (Caron et al, 2018;Pedroso et al, 2016). Consistently, our data showed an up-regulation of NPY and AgRP in TDP-43 A315T mice at disease end-stage, as previously reported by others in ALS patients and several animal models (Clark et al, 2021;Vercruysse et al, 2016) and an overall decrease in POMC expression.…”

Section: Discussionmentioning

confidence: 99%

Alterations in leptin signaling in Amyotrophic Lateral Sclerosis (ALS)

Ferrer-Donato

Contreras

Frago

et al. 2021

Preprint

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Leptin has been suggested to play a role in amyotrophic lateral sclerosis (ALS), a fatal progressive and neurodegenerative disease. This adipokine has previously been shown to be associated with a lower risk of ALS disease and to confer a survival advantage in ALS patients. However, the role of leptin in the progression of ALS is unknown. Indeed, our understanding of the mechanisms underlying leptins effects in the pathogenesis of ALS is very limited, and it is fundamental to determine whether alterations in leptins actions take place in this neurodegenerative disease. To characterize the association between leptin signaling and the clinical course of ALS we assessed the mRNA and protein expression profiles of leptin, the long leptin receptor (Ob-Rb) and leptin-related signaling pathways over the time course of the disease (onset and end-stage of disease), in TDP-43A315T mice compared to age-matched WT littermates. In addition, at the selected time-points immunoassay analysis was conducted to characterize plasma levels of total ghrelin, the adipokines (resistin and leptin) and metabolic proteins (plasminogen activator inhibitor type 1 (PAI-1), gastric inhibitory peptide (GIP), glucagon like peptide 1 (GLP-1), insulin and glucagon) in TDP-43A315T mice compared to WT controls. Our results indicate alterations in leptin signaling in the spinal cord and the hypothalamus on the backdrop of TDP-43-induced deficits in mice, providing new evidence about the pathways that could link leptin signaling to ALS.

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Section: Discussionmentioning

confidence: 99%

Alterations in leptin signaling in Amyotrophic Lateral Sclerosis (ALS)

Ferrer-Donato

Contreras

Frago

et al. 2021

Preprint

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Domestication of farmed fish via the attenuation of stress responses mediated by the hypothalamus–pituitary–inter-renal endocrine axis

Shi

Jin

et al. 2022

Front. Endocrinol.

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Human-directed domestication of terrestrial animals traditionally requires thousands of years for breeding. The most prominent behavioral features of domesticated animals include reduced aggression and enhanced tameness relative to their wild forebears, and such behaviors improve the social tolerance of domestic animals toward both humans and crowds of their own species. These behavioral responses are primarily mediated by the hypothalamic–pituitary–adrenal (inter-renal in fish) (HPA/I) endocrine axis, which is involved in the rapid conversion of neuronal-derived perceptual information into hormonal signals. Over recent decades, growing evidence implicating the attenuation of the HPA/I axis during the domestication of animals have been identified through comprehensive genomic analyses of the paleogenomic datasets of wild progenitors and their domestic congeners. Compared with that of terrestrial animals, domestication of most farmed fish species remains at early stages. The present review focuses on the application of HPI signaling attenuation to accelerate the domestication and genetic breeding of farmed fish. We anticipate that deeper understanding of HPI signaling and its implementation in the domestication of farmed fish will benefit genetic breeding to meet the global demands of the aquaculture industry.

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Author response: POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels

Cited by 2 publications

References 0 publications

Alterations in leptin signaling in Amyotrophic Lateral Sclerosis (ALS)

Alterations in leptin signaling in Amyotrophic Lateral Sclerosis (ALS)

Domestication of farmed fish via the attenuation of stress responses mediated by the hypothalamus–pituitary–inter-renal endocrine axis

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