Author response: Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons

“…Teneurin ectodomains that are proteolytically released from the cell surface bind to Latrophilins and act as attractants in axon guidance (Vysokov et al, 2018). Latrophilins (Lphn1-Lphn3 in mammals) are adhesion G-protein-coupled receptors (GPCRs) that have received attention because of their role as a calcium-independent receptor of latrotoxin (Davletov et al, 1996;Krasnoperov et al, 1996;Lelianova et al, 1997), their recently reported functions as mechanosensitive receptors (Liebscher and Schöneberg, 2016;Scholz et al, 2015Scholz et al, , 2017Stoveken et al, 2015), and their roles in neurodevelopment disorders such as attention deficit hyperactivity disorder (ADHD) (Domené et al, 2011;Lange et al, 2012;van der Voet et al, 2016). Latrophilins also interact with FN leucine-rich repeat proteins (FLRTs) in synaptogenesis (O'Sullivan et al, 2012) and engage in large supercomplexes that include Uncoordinated-5 (Unc5) receptors (Jackson et al, 2015(Jackson et al, , 2016Seiradake et al, 2016).…”