Author response: Light-induced depigmentation in planarians models the pathophysiology of acute porphyrias

Stubenhaus, Bradford M; Dustin, John P.; Neverett, Emily R; Beaudry, Megan S; Nadeau, Leanna E; Burk-McCoy, Ethan; He, Xinwen; Pearson, Bret J.; Pellettieri, Jason

doi:10.7554/elife.14175.026

Cited by 2 publications

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“…[8][9][10][11][12][13][14][15][16][17][18][19][20] Altogether the planarian model has become an excellent system for investigating in vivo stem cell biology and regeneration and it is an emerging biomedical model to study cancer and diverse human pathologies. [21][22][23][24][25] Although the immune system has been described as an important modulator of wound repair and regeneration [26][27][28] it is largely unexplored in planarians. It is likely that the mucus that covers the planarian body and whose production is greatly increased after wounding has anti-microbial properties.…”

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confidence: 99%

Planarian finds time(less) to fight infection

2017

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confidence: 99%

Planarian finds time(less) to fight infection

2017

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S-adenosylhomocysteine hydrolase regulates anterior patterning inDugesia japonica

Reinmets

Bischof

Taketa

et al. 2020

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BackgroundBiological methylation requires S-adenosylmethionine (SAM) and participates in a range of processes from modulation of gene expression via histone modifications to neurotransmitter synthesis. An important factor in all methylation reactions is the concentration ratio of SAM to methylation byproduct S-adenosylhomocysteine (SAH). SAH hydrolase, also known as adenosylhomocysteinase, depletes SAH and thereby facilitates metabolite recycling and maintains the methylation permissive SAM/SAH ratio. While the importance of SAH hydrolase in sustaining methylation is obvious on the cellular level, the function of this metabolic process on the organismal scale is not clear.ResultsWe used planarian Dugesia japonica to investigate the role SAH hydrolase in physiological homeostasis on the body-wide scale. Remarkably, pharmacological inhibition of the SAH hydrolase results in regression of anterior tissues and is accompanied by extensive apoptosis throughout the planarian body. Moreover, exposure to the SAHH inhibitor AdOx leads to changes in brain morphology and spatial shift in the expression of Wnt-modulator Notum. Strikingly, planarians are able to overcome these destructive patterning defects through regeneration of the anterior tissues and adaptation to the used inhibitor. Transcriptome analysis indicates that resistance to the SAHH inhibitor is at least partly mediated by changes in folate cycle and lipid metabolism.ConclusionsSAH hydrolase plays a critical role in planarian homeostasis and anterior patterning potentially through modulation of Wnt signaling. Moreover, planarian adaptation to the SAHH inhibitor via metabolic reprogramming suggests potential targets for addressing methylation-related human conditions.

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Author response: Light-induced depigmentation in planarians models the pathophysiology of acute porphyrias

Cited by 2 publications

References 0 publications

Planarian finds time(less) to fight infection

Planarian finds time(less) to fight infection

S-adenosylhomocysteine hydrolase regulates anterior patterning inDugesia japonica

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