Author response: Genetically manipulating endogenous Kras levels and oncogenic mutations in vivo influences tissue patterning of murine tumorigenesis

Roux, Özgün Le; Pershing, Nicole L.K.; Kaltenbrun, Erin; Newman, Nicole J; Everitt, Jeffrey I.; Baldelli, Elisa; Pierobon, Mariaelena; Petricoin, Emanuel F.; Counter, Christopher M.

doi:10.7554/elife.75715.sa2

2022

DOI: 10.7554/elife.75715.sa2

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Author response: Genetically manipulating endogenous Kras levels and oncogenic mutations in vivo influences tissue patterning of murine tumorigenesis

Özgün Le Roux

Nicole L.K. Pershing

Erin Kaltenbrun

et al.

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2023

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Mutation Mechanism In DNA: Non-Hermitian Approach

Sarısaman,

Tibatan,

Uzunal

2023

Preprint

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We propose a novel mutation mechanism for points and ordinary or palindromic sequences of DNA and RNA. We adopted non-Hermitian approaches based on quantum mechanics. Hermiticity is in the limelight of any physical structure with quantum character, like DNA, or RNA, as it creates quantum stability in that it yields real eigenvalues and orthonormal states. We show that, through the mutation mechanism we constructed based on non-Hermitian physics, the deterioration of the Hermitian character of the original DNA states, nucleotides, does not create a stability problem. We show that Weyl’s perturbation theory helps us determine the stability of mutated DNA or RNA. We prove that mutations made in the laboratory with conventional nucleotides using non-Hermitian physics methods are not different from mutations that occur spontaneously in nature. This result may help to reveal the quantum nature of genetic diseases in the near future and may shape the molecular approaches.

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Mutation Mechanism In DNA: Non-Hermitian Approach

Sarısaman,

Tibatan,

Uzunal

2023

Preprint

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Author response: Genetically manipulating endogenous Kras levels and oncogenic mutations in vivo influences tissue patterning of murine tumorigenesis

Cited by 1 publication

References 0 publications

Mutation Mechanism In DNA: Non-Hermitian Approach

Mutation Mechanism In DNA: Non-Hermitian Approach

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