Author response: Complementary networks of cortical somatostatin interneurons enforce layer specific control

Naka, Alexander; Veit, Julia; Shababo, Ben; Chance, Rebecca K.; Risso, Davide; Stafford, David; Snyder, Benjamin; Egladyous, Andrew; Chu, Desiree; Sridharan, Savitha; Mossing, Daniel P.; Paninski, Liam; Ngai, John; Adesnik, Hillel

doi:10.7554/elife.43696.035

Cited by 5 publications

(1 citation statement)

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“…The roles that these changes play in promoting sleepdependent engram neuron reactivation, sequential replay, and memory consolidation are still unclear. In the ex vivo and in vivo neocortex, SST+ interneuron activation during rhythmic upstates plays a significant role in constraining pyramidal neuron firing (Neske and Connors, 2016;Naka et al, 2019). In the context of awake behavior, the activity of SST+ (and at least a subset of PV+) interneurons is dynamically regulated by interneuron-targeting, VIP+ interneurons.…”

Section: Role Of Interneurons In Controlling Replay and Reactivation Of Learning-activated Neuronal Firing Patternsmentioning

confidence: 99%

The Engram’s Dark Horse: How Interneurons Regulate State-Dependent Memory Processing and Plasticity

Raven

Aton

2021

Front. Neural Circuits

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Brain states such as arousal and sleep play critical roles in memory encoding, storage, and recall. Recent studies have highlighted the role of engram neurons–populations of neurons activated during learning–in subsequent memory consolidation and recall. These engram populations are generally assumed to be glutamatergic, and the vast majority of data regarding the function of engram neurons have focused on glutamatergic pyramidal or granule cell populations in either the hippocampus, amygdala, or neocortex. Recent data suggest that sleep and wake states differentially regulate the activity and temporal dynamics of engram neurons. Two potential mechanisms for this regulation are either via direct regulation of glutamatergic engram neuron excitability and firing, or via state-dependent effects on interneuron populations–which in turn modulate the activity of glutamatergic engram neurons. Here, we will discuss recent findings related to the roles of interneurons in state-regulated memory processes and synaptic plasticity, and the potential therapeutic implications of understanding these mechanisms.

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Section: Role Of Interneurons In Controlling Replay and Reactivation Of Learning-activated Neuronal Firing Patternsmentioning

confidence: 99%

The Engram’s Dark Horse: How Interneurons Regulate State-Dependent Memory Processing and Plasticity

Raven

Aton

2021

Front. Neural Circuits

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All-optical recreation of naturalistic neural activity with a multifunctional transgenic reporter mouse

et al. 2023

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Toward an integrated classification of neuronal cell types: morphoelectric and transcriptomic characterization of individual GABAergic cortical neurons

Gouwens

Sorensen²,

Baftizadeh³

et al. 2020

Preprint

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Neurons are frequently classified into distinct groups or cell types on the basis of structural, physiological, or genetic attributes. To better constrain the definition of neuronal cell types, we characterized the transcriptomes and intrinsic physiological properties of over 3,700 GABAergic mouse visual cortical neurons and reconstructed the local morphologies of 350 of those neurons. We found that most transcriptomic types (t-types) occupy specific laminar positions within mouse visual cortex, and many of those t-types exhibit consistent electrophysiological and morphological features. We observed that these properties could vary continuously between ttypes, which limited the ability to predict specific t-types from other data modalities. Despite that, the data support the presence of at least 20 interneuron met-types that have congruent morphological, electrophysiological, and transcriptomic properties.

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Author response: Complementary networks of cortical somatostatin interneurons enforce layer specific control

Cited by 5 publications

References 0 publications

The Engram’s Dark Horse: How Interneurons Regulate State-Dependent Memory Processing and Plasticity

The Engram’s Dark Horse: How Interneurons Regulate State-Dependent Memory Processing and Plasticity

All-optical recreation of naturalistic neural activity with a multifunctional transgenic reporter mouse

Toward an integrated classification of neuronal cell types: morphoelectric and transcriptomic characterization of individual GABAergic cortical neurons

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