Author response: BMPs direct sensory interneuron identity in the developing spinal cord using signal-specific not morphogenic activities

Andrews, Madeline G.; Castillo, Lorenzo M del; Ochoa-Bolton, Eliana; Yamauchi, Ken; Smogorzewski, Jan; Butler, Samantha J.

doi:10.7554/elife.30647.033

Cited by 3 publications

(1 citation statement)

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“…Indeed, the generation of spinal neurons deriving from progenitors expressing either the proneural bHLH TF ATOH1 (dP1) or high levels of ASCL1 (dP3, dP5, and p2) is highly sensitive to variations in canonical BMP activity. Conversely, the production of spinal neurons deriving from progenitors expressing PTF1a (dP4), NEUROG1 (dP2, dP6-p1), NEUROG2 (pMN) and possibly NEUROG3 (p3) is much less affected by such variations (Hazen et al, 2011(Hazen et al, , 2012Andrews et al, 2017). A mechanistic explanation for this context-dependent requirement was recently proposed (Le Dréau et al, 2018).…”

Section: Promoting Stem Cell Amplification During Spinal Neurogenesismentioning

confidence: 99%

BuMPing Into Neurogenesis: How the Canonical BMP Pathway Regulates Neural Stem Cell Divisions Throughout Space and Time

Dréau

2022

Front. Neurosci.

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Bone morphogenetic proteins (BMPs) are secreted factors that contribute to many aspects of the formation of the vertebrate central nervous system (CNS), from the initial shaping of the neural primordium to the maturation of the brain and spinal cord. In particular, the canonical (SMAD1/5/8-dependent) BMP pathway appears to play a key role during neurogenesis, its activity dictating neural stem cell fate decisions and thereby regulating the growth and homeostasis of the CNS. In this mini-review, I summarize accumulating evidence demonstrating how the canonical BMP activity promotes the amplification and/or maintenance of neural stem cells at different times and in diverse regions of the vertebrate CNS, and highlight findings suggesting that this function is evolutionarily conserved.

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Section: Promoting Stem Cell Amplification During Spinal Neurogenesismentioning

confidence: 99%

BuMPing Into Neurogenesis: How the Canonical BMP Pathway Regulates Neural Stem Cell Divisions Throughout Space and Time

Dréau

2022

Front. Neurosci.

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Ligand-receptor promiscuity enables cellular addressing

Murugan

Linton

et al. 2020

Preprint

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In multicellular organisms, secreted ligands selectively activate, or “address,” specific target cell populations to control cell fate decision-making and other processes. Key cell-cell communication pathways use multiple promiscuously interacting ligands and receptors, provoking the question of how addressing specificity can emerge from molecular promiscuity. To investigate this issue, we developed a general mathematical modeling framework based on the bone morphogenetic protein (BMP) pathway architecture. We find that promiscuously interacting ligand-receptor systems allow a small number of ligands, acting in combinations, to address a larger number of individual cell types, each defined by its receptor expression profile. Promiscuous systems outperform seemingly more specific one-to-one signaling architectures in addressing capacity. Combinatorial addressing extends to groups of cell types, is robust to receptor expression noise, grows more powerful with increasing receptor multiplicity, and is maximized by specific biochemical parameter relationships. Together, these results identify fundamental design principles governing cell addressing by ligand combinations.

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Spatial transcriptomics in glioblastoma: is knowing the right zip code the key to the next therapeutic breakthrough?

Shireman,

Cheng,

Goel

et al. 2023

Front. Oncol.

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Spatial transcriptomics, the technology of visualizing cellular gene expression landscape in a cells native tissue location, has emerged as a powerful tool that allows us to address scientific questions that were elusive just a few years ago. This technological advance is a decisive jump in the technological evolution that is revolutionizing studies of tissue structure and function in health and disease through the introduction of an entirely new dimension of data, spatial context. Perhaps the organ within the body that relies most on spatial organization is the brain. The central nervous system’s complex microenvironmental and spatial architecture is tightly regulated during development, is maintained in health, and is detrimental when disturbed by pathologies. This inherent spatial complexity of the central nervous system makes it an exciting organ to study using spatial transcriptomics for pathologies primarily affecting the brain, of which Glioblastoma is one of the worst. Glioblastoma is a hyper-aggressive, incurable, neoplasm and has been hypothesized to not only integrate into the spatial architecture of the surrounding brain, but also possess an architecture of its own that might be actively remodeling the surrounding brain. In this review we will examine the current landscape of spatial transcriptomics in glioblastoma, outline novel findings emerging from the rising use of spatial transcriptomics, and discuss future directions and ultimate clinical/translational avenues.

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Author response: BMPs direct sensory interneuron identity in the developing spinal cord using signal-specific not morphogenic activities

Cited by 3 publications

References 0 publications

BuMPing Into Neurogenesis: How the Canonical BMP Pathway Regulates Neural Stem Cell Divisions Throughout Space and Time

BuMPing Into Neurogenesis: How the Canonical BMP Pathway Regulates Neural Stem Cell Divisions Throughout Space and Time

Ligand-receptor promiscuity enables cellular addressing

Spatial transcriptomics in glioblastoma: is knowing the right zip code the key to the next therapeutic breakthrough?

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