Author response: A new genetic strategy for targeting microglia in development and disease

McKinsey, Gabriel L.; Lizama, Carlos O; Keown-Lang, Amber E; Niu, Abraham; Santander, Nicolás; Larpthaveesarp, Amara; Chee, Elin; Gonzalez, Fernando; Arnold, Thomas D.

doi:10.7554/elife.54590.sa2

Cited by 3 publications

(1 citation statement)

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“…It is yet to be clarified why TMEM119 expression was preserved even in microglia activated in lesioned areas. Also, P2RY12-CreERT2 knock-in mice were able to specifically label microglia, as shown by P2ry12 - CreERT2 ; Rosa26 Rosa 26 Ai 14 reporter mice that expressed TdTomato upon Cre-dependent recombination with minor effects on CAMs (McKinsey et al, 2020 ). When P2RY12 - CreERT2 ; Rosa26 Rosa 26 Ai 14 mice underwent middle cerebral artery occlusion, tdTomato + microglia exhibited reduced immunoreactivity for P2RY12 and TMEM119 in the ischemic core and penumbra (McKinsey et al, 2020 ).…”

Section: Novel Genetic Approaches To Define Pathological Roles Of Mic...mentioning

confidence: 95%

Contribution of “Genuine Microglia” to Alzheimer's Disease Pathology

Hashioka

Inoue

Otsuki

et al. 2022

Front. Aging Neurosci.

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Section: Novel Genetic Approaches To Define Pathological Roles Of Mic...mentioning

confidence: 95%

Contribution of “Genuine Microglia” to Alzheimer's Disease Pathology

Hashioka

Inoue

Otsuki

et al. 2022

Front. Aging Neurosci.

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Alterations in Chromatin Structure and Function in the Microglia

Fujita

Yamashita

2021

Front. Cell Dev. Biol.

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Microglia are resident immune cells in the central nervous system (CNS). Microglia exhibit diversity in their morphology, density, electrophysiological properties, and gene expression profiles, and play various roles in neural development and adulthood in both physiological and pathological conditions. Recent transcriptomic analysis using bulk and single-cell RNA-seq has revealed that microglia can shift their gene expression profiles in various contexts, such as developmental stages, aging, and disease progression in the CNS, suggesting that the heterogeneity of microglia may be associated with their distinct functions. Epigenetic changes, including histone modifications and DNA methylation, coordinate gene expression, thereby contributing to the regulation of cellular state. In this review, we summarize the current knowledge regarding the epigenetic mechanisms underlying spatiotemporal and functional diversity of microglia that are altered in response to developmental stages and disease conditions. We also discuss how this knowledge may lead to advances in therapeutic approaches for diseases.

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Tackling the glial scar in spinal cord regeneration: new discoveries and future directions

Shafqat

Albalkhi

Magableh

et al. 2023

Front. Cell. Neurosci.

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Axonal regeneration and functional recovery are poor after spinal cord injury (SCI), typified by the formation of an injury scar. While this scar was traditionally believed to be primarily responsible for axonal regeneration failure, current knowledge takes a more holistic approach that considers the intrinsic growth capacity of axons. Targeting the SCI scar has also not reproducibly yielded nearly the same efficacy in animal models compared to these neuron-directed approaches. These results suggest that the major reason behind central nervous system (CNS) regeneration failure is not the injury scar but a failure to stimulate axon growth adequately. These findings raise questions about whether targeting neuroinflammation and glial scarring still constitute viable translational avenues. We provide a comprehensive review of the dual role of neuroinflammation and scarring after SCI and how future research can produce therapeutic strategies targeting the hurdles to axonal regeneration posed by these processes without compromising neuroprotection.

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Author response: A new genetic strategy for targeting microglia in development and disease

Cited by 3 publications

References 0 publications

Contribution of “Genuine Microglia” to Alzheimer's Disease Pathology

Contribution of “Genuine Microglia” to Alzheimer's Disease Pathology

Alterations in Chromatin Structure and Function in the Microglia

Tackling the glial scar in spinal cord regeneration: new discoveries and future directions

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