Author Correction: γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

Kohlgruber, Ayano C.; Gal-Oz, Shani T.; LaMarche, Nelson M.; Shimazaki, Moto; Duquette, Danielle; Koay, Hui-Fern; Nguyen, Hung N.; Mina, Amir I.; Paras, Tyler; Tavakkoli, Ali; Andrian, Ulrich H. von; Uldrich, Adam P; Godfrey, Dale I.; Banks, Alexander S.; Shay, Tal; Brenner, Michael B.; Lynch, Lydia

doi:10.1038/s41590-019-0330-4

Cited by 4 publications

(1 citation statement)

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“…Secondly, we have not fully explored the link between immune cells, fat and heat regulation. For instance, recent studies have suggested that g/d T cells reside in fat tissues and regulate the response of mice to cold (144). We have noticed visible differences in the amount of visceral fat of mice housed in the 3 different conditions (SH, SI and SI+Nest; data not shown) but have not processed these tissues for detailed histological or cytofluorimetric analyses.…”

Section: Discussionmentioning

confidence: 78%

The Immunomodulatory Effects of Social Isolation in Mice are Linked to Temperature Control

D’Acquisto¹

2021

Preprint

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Living in isolation is considered an emerging societal problem that negatively affects the physical wellbeing of its sufferers in ways that we are just starting to appreciate. This study investigates the immunomodulatory effects of social isolation in mice, utilising a two-week program of sole cage occupancy followed by the testing of immune-inflammatory resilience to bacterial sepsis. Our results revealed that mice housed in social isolation showed an increased ability to clear bacterial infection compared to control socially housed animals. These effects were associated with specific changes in whole blood gene expression profile and an increased production of classical pro-inflammatory cytokines. Interestingly, equipping socially isolated mice with artificial nests as a substitute for their natural huddling behaviour reversed the increased resistance to bacterial sepsis. These results further highlight the ability of the immune system to act as a sensor of our living conditions and to respond in a compensatory fashion to external challenges that might threaten the survival of the host.

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Section: Discussionmentioning

confidence: 78%