Author Correction: ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors

Skamagki, Maria; Correia, Cristina; Yeung, Percy Luk; Baslan, Timour; Beck, Samuel J.; Zhang, Cheng; Roß, Christian; Dang, Lam; Liu, Zhong; Giunta, Simona; Chang, Tzu Pei; Wang, Joye; Ananthanarayanan, Aparna; Bohndorf, Martina; Bosbach, Benedikt; Adjaye, James; Kim, Jonghwan; Lowe, Scott W.; Collins, James J.; Lu, Chi Wei; Hu, Li; Zhao, Rui; Kim, Kitai

doi:10.1038/s41556-018-0269-y

Cited by 2 publications

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The DUBA-SLC7A11-c-Myc axis is critical for stemness and ferroptosis

et al. 2023

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Ferroptosis is characterized by the accumulation of lipid peroxidation as a unique iron-dependent cell death. However, the interplay between stemness and ferroptosis remains unknown. Here, we demonstrate that undifferentiated cells are more sensitive to ferroptosis than differentiated cells, and cystine transporter SLC7A11 protein is highly up-regulated by deubiquitinase DUBA in differentiated cells.Additionally, DUBA promotes stemness by deubiquitinating SLC7A11. Moreover, SLC7A11 drastically increases the expression of c-Myc through cysteine, the combination of sorafenib and c-Myc inhibitor EN4 has a synergetic effect on cancer therapy. Together, our results reveal that enhanced stemness increases the susceptibility to ferroptosis, and the DUBA-SLC7A11-c-Myc axis is pivotal for differentiated cancer stem cells (CSCs) resistant to ferroptosis, providing a promised targets to eradicate CSCs through ferroptosis.

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The DUBA-SLC7A11-c-Myc axis is critical for stemness and ferroptosis

et al. 2023

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The DUBA-SLC7A11-c-Myc axis is critical for stemness and ferroptosis

Tao

Wang²,

Ouyang

et al. 2023

Preprint

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Ferroptosis is characterized by the accumulation of lipid peroxidation as a unique iron-dependent cell death. However, the interplay between stemness and ferroptosis remains unknown. Here, we demonstrate that undifferentiated cells are more sensitive to ferroptosis than differentiated cells, and cystine transporter SLC7A11 protein is highly up-regulated by deubiquitinase DUBA in differentiated cells. Additionally, DUBA promotes stemness by deubiquitinating SLC7A11. Moreover, SLC7A11 drastically increases the expression of c-Myc through cysteine, the combination of sorafenib and c-Myc inhibitor EN4 has a synergetic effect on cancer therapy. Together, our results reveal that enhanced stemness increases the susceptibility to ferroptosis, and the DUBA-SLC7A11-c-Myc axis is pivotal for differentiated cancer stem cells (CSCs) resistant to ferroptosis, providing a promised targets to eradicate CSCs through ferroptosis.

show abstract

Author Correction: ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors

Cited by 2 publications

References 0 publications

The DUBA-SLC7A11-c-Myc axis is critical for stemness and ferroptosis

The DUBA-SLC7A11-c-Myc axis is critical for stemness and ferroptosis

The DUBA-SLC7A11-c-Myc axis is critical for stemness and ferroptosis

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