Author Correction: Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure

Nava-Rivera, Lydia Enith; Betancourt-Martínez, Nadia Denys; Lozoya-Martínez, Rodrigo; Carranza-Rosales, Pilar; Guzmán-Delgado, Nancy Elena; Carranza-Torres, Irma Edith; Delgado-Aguirre, Héctor; Zambrano-Ortíz, José Omar; Morán-Martínez, Javier

doi:10.1038/s41598-022-08721-z

Cited by 2 publications

(1 citation statement)

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“…Multiple studies have demonstrated that genotoxicity and teratogenicity are interconnected. Various parental factors, such as lifestyle habits, environmental toxin exposure, smoking, and alcohol consumption, can induce genotoxic effects in reproductive cells, potentially leading to congenital abnormalities in offspring [20][21][22][23]. Therefore, we aimed to determine whether Hyunburikyung-tang causes genotoxicity or acute toxicity and provide safety information.…”

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confidence: 99%

Genotoxicity and acute toxicity of Hyunburikyung-tang: assessing the safety of prescribing traditional Korean medicine for dysmenorrhea

Jo,

hwang,

Kim

et al. 2024

Preprint

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Background Hyunburikyung-tang exerts an anti-inflammatory effect by suppressing pro-inflammatory cytokines and prostaglandin E2 and is clinically used to improve dysmenorrhea in Korea. It contains various medicinal plants including peach seeds (Prunus persica Batsch) and safflower (Carthamus tinctorius Linn). Peach seeds contain amygdalin, which demonstrates teratogenic effects, and safflower is reported to cause reproductive toxicity and teratogenic effects in mice. These findings raise concerns regarding the teratogenic potential of these substances. A potential correlation exists between genotoxicity and teratogenicity. Genotoxic substances can damage DNA and cause mutations or chromosomal abnormalities, which may result in developmental malformations. Therefore, we aimed to assess whether Hyunburikyung-tang causes acute toxicity or genotoxicity. Methods Male and female rats were orally administered Hynburikyung-tang to assess acute toxicity. Body weight measurements, general symptom observations, and autopsy examinations were used to confirm toxic responses. Genotoxicity assessment was conducted with bacteria, cells, and mice, according to the Organization for Economic Cooperation and Development (OECD) test guidelines. Results Regarding acute toxicity assessment, no toxic reactions were observed when male and female rats received oral doses of Hyunburikyung-tang (626, 1,250, or 2,500 mg/kg). The genotoxicity tests, which included assessments of reverse mutations, chromosomal aberrations, and micronucleus formation, showed no genotoxic responses. Conclusions Our findings suggested that Hyunburikyung-tang does not induce acute toxicity or genotoxicity. Nevertheless, follow-up research should be conducted to confirm toxicity caused by repeated administration.

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confidence: 99%