Author Correction: Stretching Reduces Tumor Growth in a Mouse Breast Cancer Model

Berrueta, Lisbeth; Bergholz, Johann; Muñoz, Daniel; Muskaj, Igla; Badger, Gary J.; Shukla, Anurag; Kim, H. J.; Zhao, Jean J.; Langevin, Hélène M.

doi:10.1038/s41598-018-35364-w

Cited by 3 publications

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“…Nine studies explored the effect of stretching employing different longer-term stretching protocols [ 8 , 25 – 28 , 40 , 42 , 43 , 47 ]. These studies performed the inflammatory assessment at the end of the stretching intervention, or 12- to 24-hours post-intervention.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of in vivo stretching regimens on inflammation and its relevance to translational yoga research

et al. 2022

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Objective To conduct a systematic review evaluating the impact of stretching on inflammation and its resolution using in vivo rodent models. Findings are evaluated for their potential to inform the design of clinical yoga studies to assess the impact of yogic stretching on inflammation and health. Methods Studies were identified using four databases. Eligible publications included English original peer-reviewed articles between 1900–May 2020. Studies included those investigating the effect of different stretching techniques administered to a whole rodent model and evaluating at least one inflammatory outcome. Studies stretching the musculoskeletal and integumentary systems were considered. Two reviewers removed duplicates, screened abstracts, conducted full-text reviews, and assessed methodological quality. Results Of 766 studies identified, 25 were included for synthesis. Seven (28%) studies had a high risk of bias in 3 out of 10 criteria. Experimental stretching protocols resulted in a continuum of inflammatory responses with therapeutic and injurious effects, which varied with a combination of three stretching parameters––duration, frequency, and intensity. Relative to injurious stretching, therapeutic stretching featured longer-term stretching protocols. Evidence of pro- and mixed-inflammatory effects of stretching was found in 16 muscle studies. Evidence of pro-, anti-, and mixed-inflammatory effects was found in nine longer-term stretching studies of the integumentary system. Conclusion Despite the overall high quality of these summarized studies, evaluation of stretching protocols paralleling yogic stretching is limited. Both injurious and therapeutic stretching induce aspects of inflammatory responses that varied among the different stretching protocols. Inflammatory markers, such as cytokines, are potential outcomes to consider in clinical yoga studies. Future translational research evaluating therapeutic benefits should consider in vitro studies, active vs. passive stretching, shorter-term vs. longer-term interventions, systemic vs. local effects of stretching, animal models resembling human anatomy, control and estimation of non-specific stresses, development of in vivo self-stretching paradigms targeting myofascial tissues, and in vivo models accounting for gross musculoskeletal posture.

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Section: Resultsmentioning

confidence: 99%

A systematic review of in vivo stretching regimens on inflammation and its relevance to translational yoga research

et al. 2022

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“…Similarly, circulating tumor cells were killed at high shear forces via an oxidative stress-induced mitochondrial apoptotic pathway ( Regmi et al, 2017 ). Further, it was reported that exercise or mechanical stretching of tumors caused tumor regression in a mouse model ( Betof et al, 2015 ; Berrueta et al, 2018 ). All these studies indicated that mechanical stresses could inhibit cancer growth.…”

Section: Introductionmentioning

confidence: 99%

Cancer cells can be killed mechanically or with combinations of cytoskeletal inhibitors

2022

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For over two centuries, clinicians have hypothesized that cancer developed preferentially at the sites of repeated damage, indicating that cancer is basically “continued healing.” Tumor cells can develop over time into other more malignant types in different environments. Interestingly, indefinite growth correlates with the depletion of a modular, early rigidity sensor, whereas restoring these sensors in tumor cells blocks tumor growth on soft surfaces and metastases. Importantly, normal and tumor cells from many different tissues exhibit transformed growth without the early rigidity sensor. When sensors are restored in tumor cells by replenishing depleted mechanosensory proteins that are often cytoskeletal, cells revert to normal rigidity-dependent growth. Surprisingly, transformed growth cells are sensitive to mechanical stretching or ultrasound which will cause apoptosis of transformed growth cells (Mechanoptosis). Mechanoptosis is driven by calcium entry through mechanosensitive Piezo1 channels that activate a calcium-induced calpain response commonly found in tumor cells. Since tumor cells from many different tissues are in a transformed growth state that is, characterized by increased growth, an altered cytoskeleton and mechanoptosis, it is possible to inhibit growth of many different tumors by mechanical activity and potentially by cytoskeletal inhibitors.

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Protective Roles of Exercise and Nutritional Factors for Immune System During Delta Variant-COVID-19 Outbreaks: Evidence Review and Practical Recommendations

Taati¹,

Ardakani²,

Suzuki³

et al. 2022

Iran J Med Microbiol

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Author Correction: Stretching Reduces Tumor Growth in a Mouse Breast Cancer Model

Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.

Cited by 3 publications

References 0 publications

A systematic review of in vivo stretching regimens on inflammation and its relevance to translational yoga research

A systematic review of in vivo stretching regimens on inflammation and its relevance to translational yoga research

Cancer cells can be killed mechanically or with combinations of cytoskeletal inhibitors

Protective Roles of Exercise and Nutritional Factors for Immune System During Delta Variant-COVID-19 Outbreaks: Evidence Review and Practical Recommendations

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