Author Correction: Stress gates an astrocytic energy reservoir to impair synaptic plasticity

Murphy-Royal, Ciaran; Johnston, April D.; Boyce, Andrew K. J.; Díaz-Castro, Blanca; Institóris, Ádám; Peringod, Govind; Zhang, Oliver; Stout, Robert D.; Spray, David C.; Thompson, Roger; Khakh, Baljit S.; Bains, Jaideep S.; Gordon, Grant R.

doi:10.1038/s41467-020-16668-w

Cited by 4 publications

(6 citation statements)

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“…The GJ proteins connexin 30 (Cx30) and connexin 43 (Cx43) are highly expressed in astrocytes [ 69 , 113 ], and act to shuttle glucose and its metabolites (lactate) from astrocytes to neurons in an activity-dependent manner (Fig. 2 a) [ 111 , 114 , 115 ]. In the absence of astroglial Cx30 and Cx43, astrocyte-dependent glutamate recycling and potassium buffering at the synapse is impaired.…”

Section: Astrocytes Tune Synapse Function and Synaptic Plasticitymentioning

confidence: 99%

“…This led to defects in Hebbian plasticity, including suppressed LTP and increased occurrences of long-term depression. Disruptions to astrocyte GJ proteins have been linked to impairments in LTP during memory allocation and stress in the mammalian hippocampus [115][116][117]; thus, GJ-dependent astrocyte communication is critical for developmental learning and behavior.…”

Section: Astrocyte Tiling and Synaptic Transmissionmentioning

confidence: 99%

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The role of astrocyte‐mediated plasticity in neural circuit development and function

2021

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Neuronal networks are capable of undergoing rapid structural and functional changes called plasticity, which are essential for shaping circuit function during nervous system development. These changes range from short-term modifications on the order of milliseconds, to long-term rearrangement of neural architecture that could last for the lifetime of the organism. Neural plasticity is most prominent during development, yet also plays a critical role during memory formation, behavior, and disease. Therefore, it is essential to define and characterize the mechanisms underlying the onset, duration, and form of plasticity. Astrocytes, the most numerous glial cell type in the human nervous system, are integral elements of synapses and are components of a glial network that can coordinate neural activity at a circuit-wide level. Moreover, their arrival to the CNS during late embryogenesis correlates to the onset of sensory-evoked activity, making them an interesting target for circuit plasticity studies. Technological advancements in the last decade have uncovered astrocytes as prominent regulators of circuit assembly and function. Here, we provide a brief historical perspective on our understanding of astrocytes in the nervous system, and review the latest advances on the role of astroglia in regulating circuit plasticity and function during nervous system development and homeostasis.

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Section: Astrocytes Tune Synapse Function and Synaptic Plasticitymentioning

confidence: 99%

Section: Astrocyte Tiling and Synaptic Transmissionmentioning

confidence: 99%

The role of astrocyte‐mediated plasticity in neural circuit development and function

2021

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“…The autophosphorylating Ca 2+ /calmodulin-dependent protein kinase II (CaMKII), an enzyme associated with hippocampal synaptic plasticity, is involved in LTP and LTD processes (Yasuda et al 2022). In hippocampal astrocytes, the gap-junction protein connexin 43 (Cx43) and its linker protein regulate synaptic activity (Murphy-Royal et al 2020). In addition, neurotransmitters and their receptors associated with synaptic activity also play a key role in hippocampal processes involved in PSD (Ji et al 2014).…”

Section: Introductionmentioning

confidence: 99%

A New Perspective on Hippocampal Synaptic Plasticity and Post-stroke Depression

Sun

Cui

Min

et al. 2023

Preprint

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Post-stroke depression (PSD), a common complication after stroke, severely affects the recovery and quality of life of patients with stroke. Owing to its complex mechanisms, PSD treatment remains highly challenging. Hippocampal synaptic plasticity is one of the key factors leading to PSD; however, the precise molecular mechanisms remain unclear. Numerous studies have found that neurotrophic factors, protein kinases, and neurotransmitters influence depressive behavior by modulating hippocampal synaptic plasticity. This review further elaborates on the role of hippocampal synaptic plasticity in PSD by summarizing recent research and analyzing possible molecular mechanisms. Evidence for the correlation between hippocampal mechanisms and PSD helps to better understand the pathological process of PSD and improve its treatment.

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“…The autophosphorylating Ca 2+ /calmodulin‐dependent protein kinase II (CaMKII), an enzyme associated with hippocampal synaptic plasticity, is involved in LTP and LTD processes (Yasuda et al, 2022). In hippocampal astrocytes, the gap‐junction protein connexin 43 (Cx43) and its linker protein regulate synaptic activity (Murphy‐Royal et al, 2020). In addition, neurotransmitters and their receptors associated with synaptic activity also play a key role in hippocampal processes involved in PSD (Ji et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

A new perspective on hippocampal synaptic plasticity and post‐stroke depression

Cui

Min

et al. 2023

Eur J of Neuroscience

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Post‐stroke depression, a common complication after stroke, severely affects the recovery and quality of life of patients with stroke. Owing to its complex mechanisms, post‐stroke depression treatment remains highly challenging. Hippocampal synaptic plasticity is one of the key factors leading to post‐stroke depression; however, the precise molecular mechanisms remain unclear. Numerous studies have found that neurotrophic factors, protein kinases and neurotransmitters influence depressive behaviour by modulating hippocampal synaptic plasticity. This review further elaborates on the role of hippocampal synaptic plasticity in post‐stroke depression by summarizing recent research and analysing possible molecular mechanisms. Evidence for the correlation between hippocampal mechanisms and post‐stroke depression helps to better understand the pathological process of post‐stroke depression and improve its treatment.

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Author Correction: Stress gates an astrocytic energy reservoir to impair synaptic plasticity

Cited by 4 publications

References 0 publications

The role of astrocyte‐mediated plasticity in neural circuit development and function

The role of astrocyte‐mediated plasticity in neural circuit development and function

A New Perspective on Hippocampal Synaptic Plasticity and Post-stroke Depression

A new perspective on hippocampal synaptic plasticity and post‐stroke depression

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