Author Correction: Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity

Ravasio, Andrea; Myaing, Myint Zu; Chia, Shumei; Arora, Aditya; Sathe, Aneesh R.; Cao, Elaine Yiqun; Bertocchi, Cristina; Sharma, Ankur; Arasi, Bakya; Chung, Vin Yee; Greene, Adrienne C.; Tan, Tuan Zea; Chen, Zhongwen; Ong, Hui Ting; Iyer, N. Gopalakrishna; Huang, Ruby Yun‐Ju; DasGupta, Ramanuj; Groves, Jay T.; Viasnoff, Virgile

doi:10.1038/s42003-020-01238-z

Commun Biol

2020

DOI: 10.1038/s42003-020-01238-z

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Author Correction: Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity

Andrea Ravasio

Myint Zu Myaing

Shumei Chia

et al.

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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The Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies

Chatzikalil,

Stergiou,

Papadakos

et al. 2024

IJMS

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Pediatric neoplasms represent a complex group of malignancies that pose unique challenges in terms of diagnosis, treatment, and understanding of the underlying molecular pathogenetic mechanisms. Erythropoietin-producing hepatocellular receptors (EPHs), the largest family of receptor tyrosine kinases and their membrane-tethered ligands, ephrins, orchestrate short-distance cell–cell signaling and are intricately involved in cell-pattern morphogenesis and various developmental processes. Unraveling the role of the EPH/ephrin signaling pathway in the pathophysiology of pediatric neoplasms and its clinical implications can contribute to deciphering the intricate landscape of these malignancies. The bidirectional nature of the EPH/ephrin axis is underscored by emerging evidence revealing its capacity to drive tumorigenesis, fostering cell–cell communication within the tumor microenvironment. In the context of carcinogenesis, the EPH/ephrin signaling pathway prompts a reevaluation of treatment strategies, particularly in pediatric oncology, where the modest progress in survival rates and enduring treatment toxicity necessitate novel approaches. Molecularly targeted agents have emerged as promising alternatives, prompting a shift in focus. Through a nuanced understanding of the pathway’s intricacies, we aim to lay the groundwork for personalized diagnostic and therapeutic strategies, ultimately contributing to improved outcomes for young patients grappling with neoplastic challenges.

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The Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies

Chatzikalil,

Stergiou,

Papadakos

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

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Author Correction: Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Cited by 1 publication

References 0 publications

The Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies

The Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies

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