Author Correction: Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity

Ravasio, Andrea; Myaing, Myint Zu; Chia, Shumei; Arora, Aditya; Sathe, Aneesh R.; Cao, Elaine Yiqun; Bertocchi, Cristina; Sharma, Ankur; Arasi, Bakya; Chung, Vin Yee; Greene, Adrienne C.; Tan, Tuan Zea; Chen, Z; Ong, Hui Ting; Iyer, Nisha; Huang, Ruby Yun‐Ju; DasGupta, Ramanuj; Groves, Jay T.; Viasnoff, Virgile

doi:10.1038/s42003-020-01395-1

Cited by 2 publications

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“…Considering this evidence, several studies have been conducted during the last decade, and especially during the last five years, including large single-cell analysis studies on the EPH/ephrin system, which collected and integrated gene expression data. Characteristic examples are Ravasio et al's single-cell analysis, which investigated the role of activated EPHA receptors in multiple carcinoma cells, providing a novel scoring system for EPHA clustering that can assay the heterogeneity of tumor cell types, and Shen et al's single-cell and transcriptomics study, which revealed EFNA1 as a potential prognostic marker for cervical cancer [53,54].…”

Section: Eph/ephrin Signaling In Physiologic Processes and Tumorigenesismentioning

confidence: 99%

The Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies

Chatzikalil,

Stergiou,

Papadakos

et al. 2024

IJMS

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Pediatric neoplasms represent a complex group of malignancies that pose unique challenges in terms of diagnosis, treatment, and understanding of the underlying molecular pathogenetic mechanisms. Erythropoietin-producing hepatocellular receptors (EPHs), the largest family of receptor tyrosine kinases and their membrane-tethered ligands, ephrins, orchestrate short-distance cell–cell signaling and are intricately involved in cell-pattern morphogenesis and various developmental processes. Unraveling the role of the EPH/ephrin signaling pathway in the pathophysiology of pediatric neoplasms and its clinical implications can contribute to deciphering the intricate landscape of these malignancies. The bidirectional nature of the EPH/ephrin axis is underscored by emerging evidence revealing its capacity to drive tumorigenesis, fostering cell–cell communication within the tumor microenvironment. In the context of carcinogenesis, the EPH/ephrin signaling pathway prompts a reevaluation of treatment strategies, particularly in pediatric oncology, where the modest progress in survival rates and enduring treatment toxicity necessitate novel approaches. Molecularly targeted agents have emerged as promising alternatives, prompting a shift in focus. Through a nuanced understanding of the pathway’s intricacies, we aim to lay the groundwork for personalized diagnostic and therapeutic strategies, ultimately contributing to improved outcomes for young patients grappling with neoplastic challenges.

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Section: Eph/ephrin Signaling In Physiologic Processes and Tumorigenesismentioning

confidence: 99%

The Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies

Chatzikalil,

Stergiou,

Papadakos

et al. 2024

IJMS

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show abstract

Multivalent protein-drug conjugates – An emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cells

Porębska,

Ciura,

Chorążewska

et al. 2023

Biotechnology Advances

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Author Correction: Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Cited by 2 publications

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The Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies

The Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies

Multivalent protein-drug conjugates – An emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cells

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