Author Correction: Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

Dellinger, Ryan W.; Santos, Santiago Roel; Morris, Mark; Evans, Malkanthi; Alminana, Dan; Guarente, Leonard; Marcotulli, Eric

doi:10.1038/s41514-018-0027-1

Cited by 3 publications

(4 citation statements)

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“…Animal studies showed that NR is able to increase plasma and tissue NAD + concentrations ( 8–13 ). Also in humans, NR is able to increase circulatory NAD + metabolites after several dosages ranging from 100 mg/d to 2000 mg/d ( 17–20 ). Here, we used a dosage of 1000 mg/d for 6 wk, and in line with other data presented we did not report side effects during 6 wk 1000 mg NR/d supplementation ( 17 , 19 ).…”

Section: Discussionmentioning

confidence: 99%

“…Also in humans, NR is able to increase circulatory NAD + metabolites after several dosages ranging from 100 mg/d to 2000 mg/d ( 17–20 ). Here, we used a dosage of 1000 mg/d for 6 wk, and in line with other data presented we did not report side effects during 6 wk 1000 mg NR/d supplementation ( 17 , 19 ). We investigated if NR supplementation was able to increase the NAD + metabolome in skeletal muscle tissue.…”

Section: Discussionmentioning

confidence: 99%

“…The number of human interventions with NR is small and the evidence that NR may have beneficial effects in humans is limited. Human pharmacokinetic studies showed increased circulatory NAD + metabolite concentrations in whole blood, peripheral blood mononuclear cells, and urine after various dosages of NR supplementation ( 17–22 ), varying from 300 to 2000 mg/d, indicating that NR supplementation is able to increase the NAD + pool in humans. So far, 3 randomized placebo-controlled NR supplementation studies have been performed in humans, in which the effect of NR supplementation on human metabolic health was investigated.…”

Section: Introductionmentioning

confidence: 99%

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Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Remie

Roumans

Moonen

et al. 2020

The American Journal of Clinical Nutrition

109

140

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Background Nicotinamide riboside (NR) is an NAD+ precursor that boosts cellular NAD+ concentrations. Preclinical studies have shown profound metabolic health effects after NR supplementation. Objectives We aimed to investigate the effects of 6 wk NR supplementation on insulin sensitivity, mitochondrial function, and other metabolic health parameters in overweight and obese volunteers. Methods A randomized, double-blinded, placebo-controlled, crossover intervention study was conducted in 13 healthy overweight or obese men and women. Participants received 6 wk NR (1000 mg/d) and placebo supplementation, followed by broad metabolic phenotyping, including hyperinsulinemic-euglycemic clamps, magnetic resonance spectroscopy, muscle biopsies, and assessment of ex vivo mitochondrial function and in vivo energy metabolism. Results Markers of increased NAD+ synthesis—nicotinic acid adenine dinucleotide and methyl nicotinamide—were elevated in skeletal muscle after NR compared with placebo. NR increased body fat-free mass (62.65% ± 2.49% compared with 61.32% ± 2.58% in NR and placebo, respectively; change: 1.34% ± 0.50%, P = 0.02) and increased sleeping metabolic rate. Interestingly, acetylcarnitine concentrations in skeletal muscle were increased upon NR (4558 ± 749 compared with 3025 ± 316 pmol/mg dry weight in NR and placebo, respectively; change: 1533 ± 683 pmol/mg dry weight, P = 0.04) and the capacity to form acetylcarnitine upon exercise was higher in NR than in placebo (2.99 ± 0.30 compared with 2.40 ± 0.33 mmol/kg wet weight; change: 0.53 ± 0.21 mmol/kg wet weight, P = 0.01). However, no effects of NR were found on insulin sensitivity, mitochondrial function, hepatic and intramyocellular lipid accumulation, cardiac energy status, cardiac ejection fraction, ambulatory blood pressure, plasma markers of inflammation, or energy metabolism. Conclusions NR supplementation of 1000 mg/d for 6 wk in healthy overweight or obese men and women increased skeletal muscle NAD+ metabolites, affected skeletal muscle acetylcarnitine metabolism, and induced minor changes in body composition and sleeping metabolic rate. However, no other metabolic health effects were observed. This trial was registered at clinicaltrials.gov as NCT02835664

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Remie

Roumans

Moonen

et al. 2020

The American Journal of Clinical Nutrition

109

140

View full text Add to dashboard Cite

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“…The same dose, however, failed to elicit effects on insulin parameters and glucose tolerance after 3 months in non-diabetic obese men ( 177 ). Daily supplementation of 500 mg NR with a detectable increase in NAD + serum levels did not cause serious adverse effects after 8 weeks ( 173 ). This was corroborated by a 6 week long study supplementing NR, via a commercially available supplement, which also found reduced systolic/diastolic blood pressure and arterial stiffness ( 178 ).…”

Section: Nad + Precursorsmentioning

confidence: 99%

Caloric Restriction Mimetics in Nutrition and Clinical Trials

et al. 2021

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The human diet and dietary patterns are closely linked to the health status. High-calorie Western-style diets have increasingly come under scrutiny as their caloric load and composition contribute to the development of non-communicable diseases, such as diabetes, cancer, obesity, and cardiovascular disorders. On the other hand, calorie-reduced and health-promoting diets have shown promising results in maintaining health and reducing disease burden throughout aging. More recently, pharmacological Caloric Restriction Mimetics (CRMs) have gained interest of the public and scientific community as promising candidates that mimic some of the myriad of effects induced by caloric restriction. Importantly, many of the CRM candidates activate autophagy, prolong life- and healthspan in model organisms and ameliorate diverse disease symptoms without the need to cut calories. Among others, glycolytic inhibitors (e.g., D-allulose, D-glucosamine), hydroxycitric acid, NAD+ precursors, polyamines (e.g., spermidine), polyphenols (e.g., resveratrol, dimethoxychalcones, curcumin, EGCG, quercetin) and salicylic acid qualify as CRM candidates, which are naturally available via foods and beverages. However, it is yet unclear how these bioactive substances contribute to the benefits of healthy diets. In this review, we thus discuss dietary sources, availability and intake levels of dietary CRMs. Finally, since translational research on CRMs has entered the clinical stage, we provide a summary of their effects in clinical trials.

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