Author Correction: Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis

Jeyanathan, Mangalakumari; Vaseghi‐Shanjani, Maryam; Afkhami, Sam; Grondin, Jensine A; Kang, Alisha; D’Agostino, Michael R.; Yao, Yushi; Jain, Samyak; Zganiacz, Anna; Kroezen, Zachary; Shanmuganathan, Meera; Singh, Ramandeep; Dvorkin‐Gheva, Anna; Britz‐McKibbin, Philip; Khan, Waliul I.; Xing, Zhou

doi:10.1038/s41590-023-01525-x

Nat Immunol

2023

DOI: 10.1038/s41590-023-01525-x

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Author Correction: Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis

Mangalakumari Jeyanathan

Maryam Vaseghi‐Shanjani

Sam Afkhami

et al.

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2024

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Oral administration of DNA alginate nanovaccine induced immune-protection against Helicobacter pylori in Balb/C mice

Kaveh-Samani,

Dalali,

Kaviani

et al. 2024

BMC Immunol

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Background Helicobacter pylori (H. Pylori), is an established causative factor for the development of gastric cancer and the induction of persistent stomach infections that may lead to peptic ulcers. In recent decades, several endeavours have been undertaken to develop a vaccine for H. pylori, although none have advanced to the clinical phase. The development of a successful H. pylori vaccine is hindered by particular challenges, such as the absence of secure mucosal vaccines to enhance local immune responses, the absence of identified antigens that are effective in vaccinations, and the absence of recognized indicators of protection. Methods The DNA vaccine was chemically cloned, and the cloning was verified using PCR and restriction enzyme digestion. The efficacy of the vaccination was investigated. The immunogenicity and immune-protective efficacy of the vaccination were assessed in BALB/c mice. This study demonstrated that administering a preventive Alginate/pCI-neo-UreH Nanovaccine directly into the stomach effectively triggered a robust immune response to protect against H. pylori infection in mice. Results The level of immune protection achieved with this nano vaccine was similar to that observed when using the widely accepted formalin-killed H. pylori Hel 305 as a positive control. The Alginate/pCI-neo-UreH Nanovaccine composition elicited significant mucosal and systemic antigen-specific antibody responses and strong intestinal and systemic Th1 responses. Moreover, the activation of IL-17R signaling is necessary for the defensive Th1 immune responses in the intestines triggered by Alginate/pCI-neo-UreH. Conclusion Alginate/pCI-neo-UreH is a potential Nanovaccine for use in an oral vaccine versus H. pylori infection, according to our findings.

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Oral administration of DNA alginate nanovaccine induced immune-protection against Helicobacter pylori in Balb/C mice

Kaveh-Samani,

Dalali,

Kaviani

et al. 2024

BMC Immunol

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Author Correction: Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis

Cited by 1 publication

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Oral administration of DNA alginate nanovaccine induced immune-protection against Helicobacter pylori in Balb/C mice

Oral administration of DNA alginate nanovaccine induced immune-protection against Helicobacter pylori in Balb/C mice

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