“…7 C). MHC-1 [ 30 ] and Lck [ 31 ] are key factors in the activation of T cells that are significantly upregulated in terminally exhausted CD8 + T cells under CUMS, as well as many other pathways, including the FASLG signalling pathway and PDL2 signalling pathway. Notably, PD-L1 information flow was detected only in the CUMS group ( Fig.…”