Author Correction: NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Abstract

The authors regret to report that errors in data reporting were introduced after peer review during finalization of data for publication.In Fig. 2b, the data points in the "Poor" and "Moderate" groups are shifted by approximately -30 units on the y axis. The original Fig. 2b is shown next to the corrected panel with the correct values (Supplementary Fig. 1).In the Source Data for Fig. 3b, a column is partially duplicated. These duplicated data points were erroneously reported on the panel for Fig. 3b. The original Fig. 3b is shown next to the corrected panel without the erroneous replicates (Supplementary Fig. 2). The source data for the original Fig. 3b have also been corrected and are provided. In the text, the Fig. 3 legend should have read "Five-day proliferation assay, MDA-MB-231 cells, 3% O 2 (n = 4) or 21% O 2 and with trolox (100 μM, n = 5), Fer-1 (1 μM, n = 3) or N-acetylcysteine (NAC, 750 μM, n = 3)."Also, in Extended Data Fig. 4h, the two representative images shown on the top right, while independently acquired, are from partially overlapping areas of the same tumour. We have replaced the partially duplicated image with an independent representative image (Supplementary Fig. 3).Additional supplementary files are now provided (Supplementary Figs. 1-3). Amended source data are included for Fig. 3b. Additional source data are now provided for all images (Figs. 2c and 4e and Extended Data Figs. 3b, 3c, 3f, 4c, 4h, 6i, 7a and 7b).

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“… 134 In lung cancer cells, inhibition of nitrogen fixation-1 (NFS-1), an iron-sulfur cluster biosynthetic enzyme, stimulates transferrin receptors and downmodulates ferritin that leads to ferroptosis. 135 In high-risk neuroblastoma, obstruction of a ubiquitin ligase complex leads to the ability to reduce nuclear factor erythroid 2-related factor 2 (NRF2) inhibition, upsurging heme oxygenase-1 activity and suppressing GPX4 to kill cancer cells through a natural ferroptosis inducer compound withaferin A (WA). 202 Furthermore, ferroptosis may contribute to tumor immunity beyond direct killing, particularly in association with dendritic cells that play an important role against tumor cells.…”