Author Correction: Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation

Abou-Jaoude, Antoine; Badique, L.; Mlih, Mohamed; Awan, Sara; Guo, Sunning; Lemle, Alexandre; Abboud, Clauda; Foppolo, Sophie; Host, Lionel; Terrand, Jérôme; Justiniano, Hélène; Herz, Joachim; Matz, Rachel L.; Boucher, Philippe

doi:10.1038/s41598-018-27564-1

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“…Therefore, pan-cancer analysis is essential for the early diagnosis of tumors and the development of biomarkers. SHC1, a cytoplasmic signaling protein, plays a crucial role in transmitting receptor tyrosine kinase signals, insulin signaling, regulating reactive oxygen species (ROS), stress resistance, energy metabolism, cell apoptosis, and cell apoptosis senescence ( Faisal et al, 2002 ; Bhat et al, 2015 ; Abou-Jaoude et al, 2018 ; Cao et al, 2018 ; Zhang et al, 2019 ; Hwang et al, 2020 ). Recent studies have shown that SHC1 is associated with several clinical diseases, especially in tumor development and progression ( Falco et al, 2005 ; Smith et al, 2006 ; Ahn et al, 2017b ; Chao et al, 2019b ; Huang et al, 2019 ; Wright et al, 2019 ; Borah and Bhowmick, 2020 ; Kiepas et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Pan-Cancer Study of SHC-Adaptor Protein 1 (SHC1) as a Diagnostic, Prognostic and Immunological Biomarker in Human Cancer

et al. 2022

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Background: Recent studies highlight the carcinogenesis role of SHC-adaptor protein 1 (SHC1) in cancer initiation, development, and progression. However, its aberrant expression, diagnostic and prognostic value remain unknown in a variety of tumors.Methods: The SHC1 expression profiles were analyzed using GTEx database, TCGA database, Oncomine and CPTAC database. The survival analysis was conducted using GEPIA2, Kaplan-Meier Plotter, UALCAN, and PrognoScan. The diagnostic values of SHC1 were calculated with the “pROC” package in R software. The genetic alteration of SHC1 and mutations were analyzed using cBioPortal. TIMER2 was employed to estimate the correlations between SHC1 expression and tumor-infiltrating immune cells in the TCGA cohort. Enrichment analysis of SHC1 was conducted using the R package “clusterProfiler.”Results: SHC1 was ubiquitously highly expressed and closely associated with worse prognosis of multiple major cancer types (all p < 0.05). Further, SHC1 gene mutations were strongly linked to poor OS and DFS in SKCM (all p < 0.05). An enhanced phosphorylation level of SHC1 at the S139 site was observed in clear cell RCC. Additionally, the results revealed SHC1 expression was strongly linked to TMB, MMRs, MSI, TAMs, DNA methylation, m6A RNA methylation, tumor-associated immune infiltration, and immune checkpoints in multiple cancers (all p < 0.05). In addition, the results of the ROC analysis indicated the SHC1 exhibited strong diagnostic capability for KICH (AUC = 0.92), LIHC (AUC = 0.95), and PAAD (AUC = 0.95). Finally, enrichment analysis indicated that SHC1 may potentially involve in the regulation of numerous signaling pathways in cancer metabolism and protein phosphorylation-related functions.Conclusions: These findings highlight that SHC1 plays an important role in the tumor immune microenvironment, and SHC1 has been identified to have prognostic and diagnostic value in multiple cancers. Thus, SHC1 is a potential target for cancer immunotherapy and effective prognostic and diagnostic biomarker.

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Section: Discussionmentioning

confidence: 99%

Pan-Cancer Study of SHC-Adaptor Protein 1 (SHC1) as a Diagnostic, Prognostic and Immunological Biomarker in Human Cancer

et al. 2022

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Author Correction: Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation

Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

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Pan-Cancer Study of SHC-Adaptor Protein 1 (SHC1) as a Diagnostic, Prognostic and Immunological Biomarker in Human Cancer

Pan-Cancer Study of SHC-Adaptor Protein 1 (SHC1) as a Diagnostic, Prognostic and Immunological Biomarker in Human Cancer

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