Author Correction: Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation

Abstract

The original version of this Article contained an error in the spelling of the author Sourav Maity, which was incorrectly given as Sourav Maiti. This has now been corrected in both the PDF and HTML versions of the Article.

Nucleoporins are degraded via upregulation of ESCRT-III/Vps4 complex in Drosophila models of C9-ALS/FTD

“…Humans express 12 ESCRT-III proteins, grouped into eight different families called charged multivesicular body proteins (CHMP1-8) ( Christ et al, 2017 ; Schöneberg et al, 2017 ). In Drosophila , there are eight known genes in the ESCRT-III complex, including CHMP1, Vps2 ( Drosophila homolog of CHMP2A), CHMP2B, Vps24 ( Drosophila homolog of CHMP3), Shrub ( Drosophila homolog of snf7/CHMP4), Vps60 ( Drosophila homolog of CHMP5), Vps20 ( Drosophila homolog of CHMP6), and CG5498 ( Drosophila homolog of CHMP7) ( Bertin et al, 2020 ; McCullough et al, 2013 ; Teis et al, 2008 ). Efficacy of transgenic RNAi lines targeting CHMP1, CHMP2B, Vps20, and Shrub was confirmed to reduce protein expression by ~50% ( Figures S5C – S5F ).…”

Quality control mechanisms that protect nuclear envelope identity and function

“…This idea would necessitate that ESCRTs remodel positive-curvature membranes as opposed to the more typical negative-curvature membranes. As there is evidence to support that ESCRTs can form polymers that bind to positive curvature and might execute such membrane scission reactions ( Allison et al, 2013 ; McCullough et al, 2015 ; Mast et al, 2018 ; Bertin et al, 2020 ), this is a reasonable possibility.…”

Common principles of surface deformation in biology

“…Buckling of the ESCRT-III spiral will be in competition with the deformation of the membrane, but conditions in which buckling instability can deform the membrane constitute a fairly large area of the parameter space 23 . But most mechanical properties of the ESCRT-III filaments are compatible with this mechanism, even though the trigger for buckling may come from addition of secondary subunits [28][29][30] . So what is common to buckling an epithelium and buckling of the membrane by the ECSRT-III?…”