“…A growing number of studies suggest that various cancerassociated molecules such as oncogenic proteins (HER2, EGFR, FAK, survivin, EMMPRIN, CD24, and EpCAM) and miRNAs are enriched or absent compared with healthy controls [70][71][72][73][74]. In addition, GPC1, FN, and EDIL3 are highly abundant in EVs isolated from the peripheral blood of breast cancer patients compared with healthy individuals [38,52,56,75]. Using a quantitative proteomics approach, Li et al Chena et al, have used a label-free quantitative phosphoproteomics approach and identified 144 phosphoproteins in plasma EVs that are significantly higher in patients diagnosed with breast cancer compared with healthy controls [68].…”