Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Matejcic, Marco; Saunders, Edward J.; Dadaev, Tokhir; Brook, Mark N.; Wang, Kan; Sheng, Xin; Olama, Ali Amin Al; Schumacher, Fredrick; Ingles, Sue A.; Govindasami, Koveela; Benlloch, Sara; Berndt, Sonja I.; Albanês, Demetrius; Koutros, Stella; Muir, Kenneth; Stevens, Victoria L.; Gapstur, Susan M.; Tangen, Catherine M.; Batra, Jyotsna; Clements, Judith A.; Grönberg, Henrik; Pashayan, Nora; Schleutker, Johanna; Wolk, Alicja; West, Catharine; Mucci, Lorelei A.; Kraft, Peter; Cancel‐Tassin, Géraldine; Sørensen, Karina Dalsgaard; Mæhle, Lovise; Grindedal, Eli Marie; Strom, Sara S.; Neal, David E.; Hamdy, Freddie C.; Donovan, Jenny; Travis, Ruth C.; Hamilton, Robert J.; Rosenstein, Barry S.; Lu, Yong‐Jie; Giles, Graham G.; Kibel, Adam S.; Vega, Ana; Bensen, J.T.; Kogevinas, Manolis; Penney, Kathryn L.; Park, Jong Y.; Stanford, Janet L.; Cybulski, Cezary; Nordestgaard, Børge G.; Brenner, Hermann; Maier, Christiane; Kim, Jeri; Teixeira, Manuel R.; Neuhausen, Susan L.; Ruyck, Kim De; Razack, Azad Hassan Abdul; Newcomb, Lisa F.; Lessel, Davor; Kaneva, Radka; Usmani, Nawaid; Claessens, Frank; Townsend, Paul A.; Gago‐Dominguez, Manuela; Roobol, Monique J.; Ménégaux, Florence; Khaw, Kay‐Tee; Cannon-Albright, Lisa; Pandha, Hardev; Thibodeau, Stephen N.; Schaid, Daniel J.; Wiklund, Fredrik; Chanock, Stephen J.; Easton, Douglas F.; Eeles, Rosalind; Kóte-Jarai, Zsofia; Conti, David V.; Haiman, Christopher A.; Henderson, Brian E.; Stern, Mariana C.; Thwaites, Alison; Guy, Michelle; Whitmore, Ian; Morgan, Angela; Fisher, Cyril; Hazel, Steve; Livni, Naomi; Cook, Margaret; Fachal, Laura; Weinstein, Stephanie J.; Freeman, Laura E. Beane; Hoover, Robert N.; Machiela, Mitchell J.; Lophatananon, Artitaya; Carter, Brian D.; Goodman, Phyllis J.; Moya, Leire; Srinivasan, Srilakshmi; Kedda, Mary-Anne; Yeadon, Trina; Eckert, Allison L.; Eklund, Martin; Cavalli-Bjoerkman, Carin; Dunning, Alison M.; Sipeky, Csilla; Håkansson, Niclas; Elliott, Rebecca; Ranu, Hardeep; Giovannucci, Edward; Turman, Constance; Hunter, David J.; Cussenot, Olivier; Ørntoft, Torben F.; Lane, Athene; Lewis, Sarah J.; Davis, Michael J.; Key, Tim; Brown, Paul; Kulkarni, Girish S.; Zlotta, Alexandre R.; Fleshner, Neil; Finelli, Antonio; Mao, Xueying; Marzec, Jacek; MacInnis, Robert J.; Milne, Roger L.; Hopper, John L.; Aguado, Miguel; Bustamante, Mariona; Castaño‐Vinyals, Gemma; Gràcia-Lavedán, Esther; Cecchini, L.; Stampfer, Meir J.; Ma, Jing; Sellers, Thomas A.; Geybels, Milan S.; Park, Hyun; Zachariah, Babu; Kolb, Suzanne; Wokołorczyk, Dominika; Lubiński, Jan; Kluźniak, Wojciech; Nielsen, Sune F.; Weisher, Maren; Ćuk, Katarina; Vogel, Walther; Luedeke, Manuel; Logothetis, Christopher J.; Paulo, Paula; Cardoso, Marta; Maia, Sofia; Silva, María P.; Steele, Linda; Ding, Yuan Chun; Meerleer, Gert De; Langhe, Sofie De; Thierens, Hubert; Lim, Jasmine; Tan, Meng H.; Ong, Aik T.; Lin, Daniel W.; Kachakova, Darina; Mitkova, A.; Mitev, Vanio; Parliament, Matthew; Jenster, Guido; Bangma, C.; Schröder, Fritz H.; Truong, Thérèse; Koudou, Yves Akoli; Michael, Agnieszka; Kierzek, Andrzej; Karlsson, Ami; Broms, Michael; Wu, Huihai; Aukim-Hastie, Claire; Tillmans, Lori S.; Riska, Shaun M.; McDonnell, Shannon K.; Dearnaley, David P.; Spurdle, Amanda B.; Gardiner, Robert A.; Hayes, Vanessa M.; Butler, Lisa M.; Taylor, Renea A.; Papargiris, Melissa; Saunders, Pamela; Kujala, Paula; Talala, Kirsi; Taari, Kimmo; Bentzen, Søren M.; Hicks, Belynda; Vogt, Aurélie; Hutchinson, Amy; Cox, Angela; George, Anne; Toi, Ants; Evans, Andrew; Kwast, Theodorus H. van der; Imai, Takashi; Saito, Shiro; Zhao, Shan‐Chao; Ren, Guoping; Zhang, Yangling; Yu, Yongwei; Wu, Yuchen; Wu, Ji; Zhou, Bo; Pedersen, John; Lobato-Busto, Ramón; Ruiz-Dominguez, José Manuel; Mengual, Lourdes; Alcaraz, Antonio; Pow‐Sang, Julio M.; Herkommer, Kathleen; Vlahova, Aleksandrina; Dikov, Tihomir; Christova, S.; Carracedo, Ángel; Trétarre, Brigitte; Rébillard, Xavier; Mulot, Claire; Adolfsson, Jan; Stattin, Pär; Johansson, Jan‐Erik; Martin, Richard M; Thompson, Ian M.; Chambers, Suzanne K.; Aitken, Joanne F.; Horvath, Lisa Kristina; Haynes, Anne‐Maree; Tilley, Wayne D.; Risbridger, Gail P.; Aly, Markus; Nordström, Tobias; Pharoah, Paul; Tammela, Teuvo L.J.; Murtola, T.; Auvinen, Anssi; Burnet, N.G.; Barnett, Gill; Andriole, Gerald L.; Klim, Aleksandra; Drake, Bettina F.; Borre, Michael; Kerns, Sarah L.; Ostrer, Harry; Zhang, Hongwei; Cao, Guangwen; Lin, Ji; Jin, Ling; Li, Meiling; Feng, Na; Li, Jie; He, Weiyang; Guo, Xin; Sun, Zan; Wang, Guomin; Guo, Jianming; Southey, Melissa C.; FitzGerald, Liesel M.; Marsden, Gemma; Gómez-Caamaño, Antonio; Carballo, Ana; Peleteiro, Paula; Calvo, Patricia; Szulkin, Robert; Llorca, Javier; Dierssen-Sotos, Trinidad; Gómez‐Acebo, Inés; Lin, Hui‐Yi; Ostrander, Elaine A.; Bisbjerg, Rasmus; Klarskov, Peter; Røder, Martin Andreas; Iversen, Peter; Holleczek, Bernd; Stegmaier, Christa; Schnoeller, Thomas; Bohnert, Philipp; John, Esther M.; Ost, P.; Teo, Soo‐Hwang; Gamulin, Marija; Kuliš, Tomislav; Kaštelan, Željko; Slavov, Chavdar; Popov, Elenko; Broeck, Thomas Van den; Joniau, Steven; Larkin, Samantha; Castelao, Jose E.; Martı́nez, Marı́a Elena; Schaik, Ron H.N. van; Xu, Jianfeng; Lindström, Sara; Riboli, Elio; Berry, Clare; Siddiq, Afshan; Canzian, Federico; Kolonel, Laurence N.; Marchand, Loı̈c Le; Freedman, Matthew L.; Cénée, Sylvie; Sanchez, Marie

doi:10.1038/s41467-019-08293-z

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“…Long noncoding RNAs (lncRNAs) play an important role in various biological and pathological processes frequently implicated in cancer, including proliferation, apoptosis, cell cycle progression, migration, and invasion [4]. Plasmocytoma variant translocation 1 (PVT1) is a long nonprotein-coding gene located at the 8q24 human chromosomal region and is commonly dysregulated in PCa [5,6]. The PVT1 gene locus is comprised of at least twelve exons, which gives rise to several alternatively spliced nonprotein coding transcripts, and encodes six microRNAs: miR-1204, miR-1205, miR-1207-3p, miR-1207-5p, and miR-1208 [7].…”

Section: Introductionmentioning

confidence: 99%

Long Noncoding RNA from PVT1 Exon 9 Is Overexpressed in Prostate Cancer and Induces Malignant Transformation and Castration Resistance in Prostate Epithelial Cells

Pal

Huaman

Levine

et al. 2019

Genes

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Prostate cancer (PCa) is the most common non-cutaneous cancer and second leading cause of cancer-related death for men in the United States. The nonprotein coding gene locus plasmacytoma variant translocation 1 (PVT1) is located at 8q24 and is dysregulated in different cancers. PVT1 gives rise to several alternatively spliced transcripts and microRNAs. There are at least twelve exons of PVT1, which make separate transcripts, and likely have different functions. Here, we demonstrate that PVT1 exon 9 is significantly overexpressed in PCa tissues in comparison to normal prostate tissues. Both transient and stable overexpression of PVT1 exon 9 significantly induced greater prostate epithelial cell migration, as well as increased proliferation and corresponding proliferating cell nuclear antigen (PCNA) expression. Notably, implantation into mice of a non-tumorigenic prostate epithelial cell line stably overexpressing PVT1 exon 9 resulted in the formation of malignant tumors. Furthermore, PVT1 exon 9 overexpression significantly induced castration resistance. Consequently, PVT1 exon 9 expression is important for PCa initiation and progression, and holds promise as a therapeutic target in PCa.

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Section: Introductionmentioning

confidence: 99%

Long Noncoding RNA from PVT1 Exon 9 Is Overexpressed in Prostate Cancer and Induces Malignant Transformation and Castration Resistance in Prostate Epithelial Cells

Pal

Huaman

Levine

et al. 2019

Genes

View full text Add to dashboard Cite

show abstract

Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Abstract: The original version of this Article contained an error in the spelling of the author Manuela Gago-Dominguez, which was incorrectly given as Manuela G. Dominguez. This has now been corrected in both the PDF and HTML versions of the Article.

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Long Noncoding RNA from PVT1 Exon 9 Is Overexpressed in Prostate Cancer and Induces Malignant Transformation and Castration Resistance in Prostate Epithelial Cells

Long Noncoding RNA from PVT1 Exon 9 Is Overexpressed in Prostate Cancer and Induces Malignant Transformation and Castration Resistance in Prostate Epithelial Cells

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