Author Correction: Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen
            <i>Candida auris</i>

Rhodes, Johanna; Abdolrasouli, Alireza; Farrer, Rhys A.; Cuomo, Christina A.; Aanensen, David M.; Armstrong‐James, Darius; Fisher, Matthew C.; Schelenz, Silke

doi:10.1038/s41426-018-0098-x

Cited by 22 publications

(26 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Using Oxford Nanopore and Illumina sequencing technologies to gather genomic data on those clinical isolates, Rhodes et al placed the United Kingdom outbreak in the India/Pakistan clade (Clade I), demonstrating an Asian origin for the outbreak. Rhodes et al (2018a) were also able to estimate the timing for the most recent common ancestor (MRCA) of those outbreak strains to late March 2015, which was just weeks prior to the first patient identified with a C. auris infection. Additionally, by using root-to-tip regression, Rhodes et al (2018a) estimated the evolutionary rate of the C. auris nuclear genome to 5.7 × 10 −5 substitutions per site per year, a slower rate to the nuclear DNA of other related fungal species in the Saccharomycetales such as Saccharomyces cerevisiae (5.7 × 10 −3 ), as well as more distantly related species such as the Schizosaccharomyces pombe traditional beer strains (3.0 × 10 −3 ).…”

Section: Genomic Epidemiology Of C Aurismentioning

confidence: 99%

“…Almost onethird of isolates observed so far were resistant to amphotericin B (a polyene used as a last resort drug) (Warris, 2018). Although the nucleoside analog 5-flucytosine successfully treated more than 95% of C. auris infection cases in vitro (Lockhart et al, 2017a; Osei Sekyere, 2018), it is not used extensively as therapy because resistance arises rapidly, potentially during treatment (Rhodes et al, 2018a), and it elicits toxic effects on bone marrow that may lead to death in immunosuppressed patients (Vermes et al, 2000). Between 2 and 7% of C. auris isolates have developed resistance to echinocandins (Lockhart et al, 2017b;Chowdhary et al, 2018), one the newest classes of antifungal drug to be developed (Sucher et al, 2009).…”

Section: Antifungal Treatment Of C Aurismentioning

confidence: 99%

See 1 more Smart Citation

Nine Things Genomics Can Tell Us About Candida auris

2020

Self Cite

View full text Add to dashboard Cite

Candida auris is a recently emerged multidrug-resistant fungal pathogen causing severe illness in hospitalized patients. C. auris is most closely related to a few environmental or rarely observed but cosmopolitan Candida species. However, C. auris is unique in the concern it is generating among public health agencies for its rapid emergence, difficulty to treat, and the likelihood for further and more extensive outbreaks and spread. To date, five geographically distributed and genetically divergent lineages have been identified, none of which includes isolates that were collected prior to 1996. Indeed, C. auris' ecological niche(s) and emergence remain enigmatic, although a number of hypotheses have been proposed. Recent genomic and transcriptomic work has also identified a variety of gene and chromosomal features that may have conferred C. auris with several important clinical phenotypes including its drug-resistance and growth at high temperatures. In this review we discuss nine major lines of enquiry into C. auris that big-data technologies and analytical approaches are beginning to answer.

show abstract

Section: Genomic Epidemiology Of C Aurismentioning

confidence: 99%

Section: Antifungal Treatment Of C Aurismentioning

confidence: 99%

Nine Things Genomics Can Tell Us About Candida auris

2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Each clade is strongly associated with distinct geographic regions and differs from other clades by tens of thousands of single-nucleotide polymorphisms (SNPs), while the genetic diversity within a clade is extremely low (10). These clades are most often referenced by the geographic region they were first associated with clade I (South Asia), clade II (East Asia), clade III (Africa), and clade IV (South America) (10)(11)(12). In the age of globalization and international travel, it is important to note that without a definitive origin or a comprehensive evolutionary rate analysis, this geographic distribution could be the result of importation and local spread rather than reflecting the origination points of these clades (13).…”

mentioning

confidence: 99%

“…Eight of these clinical cases have travel-related epidemiological links, indicating that initial travel-related cases seeded the U.S. C. auris population. Clades I and III predominate in European outbreaks studied to date (12,15,16). Because fewer clinical isolates have been recovered from clade II, there is a substantial gap in in C. auris research to date, and it is therefore poorly understood relative to the other clades.…”

mentioning

confidence: 99%

Insights into the Unique Nature of the East Asian Clade of the Emerging Pathogenic Yeast Candida auris

et al. 2019

View full text Add to dashboard Cite

The emerging yeast Candida auris can be highly drug resistant, causing invasive infections, and large outbreaks. C. auris went from an unknown pathogen a decade ago to being reported in over thirty countries on six continents. C. auris consists of four discrete clades, based on where the first isolates of the clade were reported, South Asian (clade I), East Asian (clade II), African (clade III), and South American (clade IV). These clades have unique genetic and biochemical characteristics that are important to understand and inform the global response to C. auris. Clade II has been underrepresented in the literature despite being the first one discovered. In this issue of the Journal of Clinical Microbiology, Y. J. Kwon et al. (J Clin Microbiol 57:e01624-18, 2019, https://doi.org/10.1128/JCM.01624-18) describe the largest collection of clinical isolates from Clade II, which is also the longest-running span of clinical cases, 20 years, from any single region to date. Clade II appears to have a propensity for the ear that is uncharacteristic of the other clades, which typically cause invasive infections and large-scale outbreaks. This study provides new information on an understudied lineage of C. auris and has important implications for future surveillance.

show abstract

“…Genomic analyses of these early cases identified four geographically stratified genetic subdivisions or clades (47). More recently reported outbreaks are predominantly linked to three of these clades (48)(49)(50), and a fifth potential clade was identified in 2018 from a single isolate from Iran (51). While in many countries C. auris is still a rare cause of infection, the pathogen is now responsible for a major proportion of candidemia in other regions (52).…”

Section: Emerging Fungal Threats To Humansmentioning

confidence: 99%

Threats Posed by the Fungal Kingdom to Humans, Wildlife, and Agriculture

Fisher

Gurr

Cuomo

et al. 2020

mBio

Self Cite

334

256

View full text Add to dashboard Cite

The fungal kingdom includes at least 6 million eukaryotic species and is remarkable with respect to its profound impact on global health, biodiversity, ecology, agriculture, manufacturing, and biomedical research. Approximately 625 fungal species have been reported to infect vertebrates, 200 of which can be human associated, either as commensals and members of our microbiome or as pathogens that cause infectious diseases. These organisms pose a growing threat to human health with the global increase in the incidence of invasive fungal infections, prevalence of fungal allergy, and the evolution of fungal pathogens resistant to some or all current classes of antifungals. More broadly, there has been an unprecedented and worldwide emergence of fungal pathogens affecting animal and plant biodiversity. Approximately 8,000 species of fungi and Oomycetes are associated with plant disease. Indeed, across agriculture, such fungal diseases of plants include new devastating epidemics of trees and jeopardize food security worldwide by causing epidemics in staple and commodity crops that feed billions. Further, ingestion of mycotoxins contributes to ill health and causes cancer. Coordinated international research efforts, enhanced technology translation, and greater policy outreach by scientists are needed to more fully understand the biology and drivers that underlie the emergence of fungal diseases and to mitigate against their impacts. Here, we focus on poignant examples of emerging fungal threats in each of three areas: human health, wildlife biodiversity, and food security.

show abstract

Author Correction: Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris

Cited by 22 publications

References 1 publication

Nine Things Genomics Can Tell Us About Candida auris

Nine Things Genomics Can Tell Us About Candida auris

Insights into the Unique Nature of the East Asian Clade of the Emerging Pathogenic Yeast Candida auris

Threats Posed by the Fungal Kingdom to Humans, Wildlife, and Agriculture

Contact Info

Product

Resources

About